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Potentialities of manganese ore and iron-carbon particles for pharmaceuticals and personal care products removal in electroactive constructed wetland
This study explores the use of manganese ore, iron-carbon particles (Fe-C), and gravel as anode fillers in electroactive constructed wetlands (ECWs) to treat wastewater containing pharmaceuticals and personal care products (PPCPs) including ciprofloxacin (CIP), ofloxacin (OFL), and naproxen (NPX), while also assessing bioelectricity production. Although the presence of PPCPs reduced pollutant remo
Development and validation of a novel Simoa assay for NPTX2 in Alzheimer's disease and Down syndrome
INTRODUCTION: Synaptic dysfunction and loss are pathological hallmarks of neurodegenerative diseases. Neuronal pentraxin 2 (NPTX2), a presynaptic protein involved in synaptic plasticity, has been linked to cognitive decline in Alzheimer's disease (AD) and other neurodegenerative disorders. METHODS: We developed and validated a novel single molecule array (Simoa) for NPTX2 in cerebrospinal fluid, w
Many group A streptococcal strains express two different immunoglobulin-binding proteins, encoded by closely linked genes: characterization of the proteins expressed by four strains of different M-type
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GigaFRoST : The gigabit fast readout system for tomography
Owing to recent developments in CMOS technology, it is now possible to exploit tomographic microscopy at third-generation synchrotron facilities with unprecedented speeds. Despite this rapid technical progress, one crucial limitation for the investigation of realistic dynamic systems has remained: A generally short total acquisition time at high frame rates due to the limited internal memory of av
Structural determination of Streptococcus pyogenes M1 protein interactions with human immunoglobulin G using integrative structural biology
Streptococcus pyogenes (Group A streptococcus; GAS) is an important human pathogen responsible for mild to severe, life-threatening infections. GAS expresses a wide range of virulence factors, including the M family proteins. The M proteins allow the bacteria to evade parts of the human immune defenses by triggering the formation of a dense coat of plasma proteins surrounding the bacteria, includi
Efficacy of T-cell assays for the diagnosis of primary defects in cytotoxic lymphocyte exocytosis
Primary hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disorder associated with autosomal recessive variants in genes required for perforin-mediated lymphocyte cytotoxicity. A rapid diagnosis is crucial for successful treatment. Although defective cytotoxic T lymphocyte (CTL) function causes pathogenesis, quantification of natural killer (NK)–cell exocytosis triggered by K562 targe
Group G streptococcal IgG binding molecules FOG and protein G have different impacts on opsonization by C1q
Recent epidemiological data on diseases caused by beta-hemolytic streptococci belonging to Lancefield group C and G ( GCS, GGS) underline that they are an emerging threat to human health. Among various virulence factors expressed by GCS and GGS isolates from human infections, M and M-like proteins are considered important because of their anti-phagocytic activity. In addition, protein G has been i
Results of a phase I/II study of ocrelizumab, a fully humanized anti-CD20 mAb, in patients with relapsed/refractory follicular lymphoma
Background: Ocrelizumab is a humanized anti-CD20 antibody with increased antibody-dependent cellular cytotoxicity compared with rituximab. This phase I/II study evaluated its safety and efficacy in patients with relapsed/refractory follicular lymphoma (FL) after prior rituximab therapy. Design and methods: Forty-seven patients were treated in three dose cohorts and received eight infusions every 3
Streptococcus pyogenes secreted enzymes interacting with the human host
Streptococcus pyogenes is one of the most common bacteria infecting humans. One of the factors contributing to the disease-causing properties is the secreted streptococcal cysteine proteinase, SpeB, which degrades several host proteins in connective tissue and circulation. SpeB activity depends on the transformation from an inactive precursor, zymogen, into a mature proteinase. We show that
Stainless Steel in Mobile Phones
This master thesis explores the usage of stainless steel in mobile phones. The first part is an introduction to stainless steel which explains the properties of the different stainless steels, and also the most common methods used for sheet metal production. It is concluded with a selection process to determine which stainless steels are best suited to be used at Sony Ericsson Mobile Communication
Sushi domain-containing protein 4 (SUSD4) inhibits complement by disrupting the formation of the classical C3 convertase.
Protein H--a bacterial surface protein with affinity for both immunoglobulin and fibronectin type III domains
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Rifm fragrance ingredient safety assessment, (2E,6Z)-Nona-2,6-dien-1-ol, CAS registry number 28069-72-9.
Reaching Beyond your Base? Incumbent and Opposition Party Nationalization in 26 Sub-Saharan African States
t(3;12)(q26;q14) in polycythemia vera is associated with upregulation of the HMGA2 gene
RIFM fragrance ingredient safety assessment, 2,6-Dimethyl-5-heptenal, CAS Registry Number 106-72-9.
The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as environmental assessment. Repeated dose toxicity was determined to have the most conservative systemic
