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INTRODUCTION: We aimed to develop an algorithm to predict the individualized risk of future dementia using brief cognitive tests suitable for primary care. METHODS: We included 612 participants with subjective cognitive decline (SCD) or mild cognitive impairment (MCI) from the Alzheimer's Disease Neuroimaging Initiative (ADNI) study, assessed for at least 4 years or until progression to dementia.

Objective: Progressive Supranuclear Palsy (PSP) is a severe neurodegenerative disease characterized by tangles of hyperphosphorylated tau protein and tufted astrocytes. Developing treatments for PSP is challenging due to the lack of disease models reproducing its key pathological features. This study aimed to model sporadic PSP-Richardson's syndrome (PSP-RS) using multi-donor midbrain organoids (M

The dopamine transporter (DAT) is responsible for dopamine (DA) clearance in the synaptic cleft, and thus crucial for maintaining DA homeostasis in the central nervous system (CNS). Mutations in the DAT coding gene have been associated with both movement and psychiatric disorders, such as parkinsonism and attention-deficit hyperactivity disorder (ADHD). However, the detailed contribution of DAT in

Equitable distribution of healthcare services towards the reduction of HIV-AIDS prevalence in Nigeria remains a major public health concern. One of several research model to solve this public health problem is the use Geographical Information System, a two-step floating catchment area (2SFCA), this model emerged in the last decade as a key measure of spatial accessibility, particularly in its appl

For most people getting a stroller is an obvious thing to do when having a baby. It’s mainly used for transportation of the baby but has other functions as well. For example, it is used as a storage, serves as a shopping bag for groceries and makes a perfect bed for a baby nap. Using a stroller should be easy and safe, but when it’s getting dark outside it can be hard to see the road ahead and fin

Purpose: The purpose of this research was to understand how consumers morally judge advocacy advertising in contemporary consumer culture. The phenomenon was explored with the help of three case studies, namely Nike, Gillette, and Pepsi, all being brands who have taken a political stance in their advertisement campaigns. Theoretical Perspective: To analyse the empirical material, we first delved

Author: Johanna Lövall Title: ‘ You can get it everywhere’. Parents' views on their ability to influence young people's approach to alcohol and drugs. Supervisor: Teres Hjärpe Assessor: Katarina Jacobsson Background: There is extensive research from different national contexts pointing out parents and some specific parenting approaches as important in preventing or counteracting youth alc

With increasing amounts of generated research data, relevant for saving and sharing, as well as higher demands on more open and transparent research, research data management has become an important issue for all involved in the research community. Open access to research data is promoted using arguments concerning public good, research transparency and quality control, the bringing of new researc

Luminiscensdatering är ett viktigt verktyg inom geologin för att tidsbestämma geologiska avsättningsprocesser i jordens historia. Grundförutsättningen för en korrekt datering är att luminiscenssignalen genererad från ett mineral nollställs vid kontakt med solljus. Vid insamling och preparering av provmaterial är det därför av yttersta vikt att ingen ljusexponering inträffar som eventuellt nollstälLuminescence dating provides an important tool in geology to reconstruct geological depositions events in the Earth’s past. The basic assumption for a reliable dating is that luminescence generated from minerals resets at the time when it was last exposed to sunlight. The accuracy and precision of luminescence dating is therefore strongly dependant on preparation of the sediment to be in dark cond

In the last decades, scholars, managers and consultants have shown increased interest in identifying the characteristics of high-performance organizations. Searching for ways to improve organizational performance and respond to a growing demand for quality products and services in a rapidly changing environment, this subject is of special interest of managers in both public and private organizatio

Bio-based plastics are increasingly considered as sustainable alternatives to fossil-based plastics. Up until now, their application in the food packaging industry has been limited. The purpose of this study is to investigate the applicability of bio-based polymer packaging films for bakery products, herbs and spices in the meal kit industry context and to assess their contribution towards a more

The Brazilian LGBT movement has established in the last decades a strategy of action based on the achievement of social transformations through law. The struggle for human rights has become the focal point of the LGBT agenda in the country. For this reason, the linkages between the Brazilian LGBT movement and the law have multiplied. Having the objective of reflecting on the articulations arising

Under anaerobic condition the specific growth rate of Lactobacillus reuteri DSM 17938 on different sugars, was analyzed using spectrophotometry. Electron acceptor (fructose) supported cells to cope with poor energy recovery by re-oxidising the NADH, thus enabling ATP formation thru acetate production, while fermenting glucose via the phosphoketolase pathway (PKP) and simultaneously operating via E

Home based work is considered as work with low economic value and low waged. The Home base work is also preserved to be a principal way to earn a living for women. The traditional home based works for instance thread making, weaving, dairying, basket making etc., were such kind of work which carried out at home, still exists particularly in developing countries. Since a huge number of home base wo

ISO 14001:2004 is the most commonly used standard for third-party certification of Environmental Management Systems (EMS) in the world. It is currently undergoing an upgrading process, which will affect all the companies certified to ISO 14001. A first draft has been produced, the Committee Draft 1 (CD1). The thesis has two research questions: What are the most likely changes in the new version

In this project, Esaki tunnel diodes have been made of InP(n+)/InGaAs(p+) core/sell nanowires and current-voltage characteristics of the nanowire tunnel diodes for future electronic and photovoltaic application have been investigated. Six different groups of nanowires with different doping concentrations of the shell have been studied with the aim of finding the best nanowire condition to use in t

Title: Insider trading and abnormal return on the Swedish stock market Seminar Date: 2015-05-25 Course: FEKN90 Examensarbete på civilekonomprogrammet (30hp) Authors: Philip Ek and Karin Erlinder Advisor: Rikard Larsson Purpose: By using classifications of different kinds of insiders we wish to en-lighten this area of study with empirical evidence of how insiders on the Swedish Stock Exchange

The aim of this thesis is to examine if fiction books can be used as a support for young adults in families where one of the parents suffer from mental illness. I have used a qualitative method and have made a content analysis on five fiction books for young adults. The fiction books were found on a list of book recommendations published on Psykiatri Skåne’s webpage dedicated for relatives of peop

Objective The primary objective of this study was to assess the impact of atomoxetine in combination with psychoeducation, compared with placebo and psychoeducation, on health-related quality of life (HRQL) in Swedish stimulant-naive pediatric patients with attention deficit/hyperactivity disorder (ADHD). HRQL results will be presented elsewhere. Here, psychoeducation as well as efficacy and safet