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Context: Prostate cancer (PCa) is one of the most common human malignancies and arises through genetic and epigenetic alterations. Epigenetic modifications include DNA methylation, histone modifications, and microRNAs (miRNA) and produce heritable changes in gene expression without altering the DNA coding sequence. Objective: To review progress in the understanding of PCa epigenetics and to focus
In recent years, smog has become one of greatest challenges in China and many other countries. However, there are limited attentions of measuring public environment awareness of air pollution and the relations between public environmental awareness and smog prevention in a Chinese context. This study was designed to investigate the facts of public environmental awareness in a typical city of China
This paper presents the study of a mid-sized semi-closed oxy-fuel combustion combined cycle (SCOC-CC) with net power output around 108 MW. The paper describes not only the power balance and the performance of the SCOC-CC, but also the conceptual design of the SCOC turbine and compressor. A model has been built in the commercial heat and mass balance code IPSEpro to estimate the efficiency of semi-
1. The European Water Framework Directive requires the determination of ecological status in European fresh and saline waters. This is to be through the establishment of a typology of surface water bodies, the determination of reference (high status) conditions in each element (ecotype) of the typology and of lower grades of status (good, moderate, poor and bad) for each ecotype. It then requires
Popular Abstract in Swedish Alla levande celler har förmåga att känna av och på olika sätt anpassa sig till sin omgivning, antingen de ensamma utgör en hel organism eller är en av många miljarder celler i ett stort djur. Varje enskild cell kan bara ta emot en begränsat mängd olika sorters signaler och bara reagera på ett likaledes begränsat antal sätt. Den en- eller fåcelliga organismen är därmed The G protein-coupled receptors form one of the largest families of proteins involved in signalling between cells. It contains receptors for molecules as diverse as biogenic amines, glycoproteins and enzymes. The manuscripts included in this thesis together describe the initial characterisation of a previously unknown receptor of this class. A DNA fragment was cloned from a mouse genomic library.
Prostate-specific antigen (PSA) is a glycoprotein produced by the prostate gland. It occurs in several molecular forms in the blood and assays have been developed to measure free PSA and PSA in complex with alpha-1-antichymotrypsin (PSA-ACT). Higher proportions of free PSA (PSA-F/T) in blood are found in subjects with benign prostatic hyperplasia (BPH) as compared to cancer patients. Utilizing imm
Objective. Patients with hepatitis C have been shown to have impaired health-related quality of life (HRQoL). The aim of this study was to determine HRQoL in patients in different stages of hepatitis C virus (HCV) and to compare HRQoL in HCV cirrhosis with non-HCV-induced cirrhosis. Material and methods. Out of 489 consecutive patients who fulfilled the inclusion criteria, 472 (96%) agreed to part
Minimally modified low density lipoprotein (mmLDL) is a well-known risk factor for coronary artery disease. Upregulation of vascular endothelin type B (ETB) receptors on the vascular smooth muscle cells is predicted to be the molecular mechanism that leads to cardiovascular pathogenesis. The objective of the present study was to examine the hypothesis that mmLDL upregulates ETB receptors in rat co
Popular Abstract in Swedish SAMMANFATTNING PÅ SVENSKA Systemisk Lupus Erytematosus (SLE) är en kronisk inflammatorisk system sjukdom. Sjukdomen yttrar sig med stor variation, både avseende vilka organ områden och med vilken intensitet olika organ kan bli engagerade. Genom åren har prognosen för sjukdomen i sig dramatiskt förbättrats, genom att alla typer av organ manifestationer kan behandlas. SeSystemic Lupus Erythematosus is an autoimmune disease with a wide range of disease manifestations with respect to severity and magnitude of organ involvement. An increased risk of cardiovascular disease (CVD) compared with the general population causes both morbidity and mortality in SLE patients. Consequently prevention, early detection and treatment of arteriosclerotic manifestations are of high
Background and purpose MRI is the modality of choice when diagnosing spinal stenosis but it also shows that stenosis is prevalent in asymptomatic subjects over 60. The relationship between preoperative health-related quality of life, functional status, leg and back pain, and the objectively measured dural sac area in single and multilevel stenosis is unknown. We assessed this relationship in a pro
This paper presents the development of an experimentally validated model that mechanistically comprehends the complex interaction between the gas-phase fluid dynamics, the mass transport of individual species, and the heterogeneous gas-surface reaction mechanism in a continuous cross-flow atomic layer deposition (ALD) reactor. The developed ALD gas-surface reaction mechanism, purely based on conse
Developing useful biological isoscapes for areas of the world is a priority. This is the case for Mexico that hosts a large percentage of North America's Neotropical migrant birds. Here we investigated the use of House Sparrow (Passer domesticus) feathers to create a spatially explicit feather deuterium isoscape for that country using samples (n=461) that were collected across Mexico. Considerable
Caveolae, plasma membrane invaginations particularly abundant in adipocytes, have been suggested to be important in organizing insulin signalling. Insulin-induced activation of the membrane bound cAMP degrading enzyme, phosphodiesterase 3B (PDE3B) is a key step in insulin-mediated inhibition of lipolysis and is also involved in the regulation of insulin-mediated glucose uptake and lipogenesis in a
This paper presents a method designed to identify underlying causes leading to industrial accidents. The method developed intends to facilitate the learning process from accidents by identifying possible causes related to the accidents that were not directly stated in an accident report, but that can be deduced following the description of the event, in particular with regard to the quality of the
Attaining high peak bone mass (PBM), the highest bone mass value in life which is reached in young adulthood, is important as it reduces the risk of having low bone mass in old age69, 80. Low bone mass is associated with high fracture risk3, 60. Osteoporosis is the result of bone loss, a physiological process related to aging and/or low PBM. It would therefore be of great value to identify childre
Popular Abstract in Swedish De flesta större operationer på hjärtat idag kräver att hjärtat under en del av operationen står stilla utan att blod cirkulerar igenom det. För att kunna bibehålla ett blodflöde av syresatt blod genom kroppen kopplas en hjärt-lungmaskin till patienten. Blodet förs via slangar från höger förmak först ner till ett uppsamlingskärl, varifrån blodet pumpas vidare genom en oThe use of cardiotomy suction during open heart surgery with cardiopulmonary bypass (CPB) has a long tradition and often regarded as mandatory. Recently, studies have described potentially negative effects of cardiotomy suction with activation of the complement system, enhanced inflammatory response, hemolysis and coagulopathy. Emboli of various matters has also been studied. Whether they affect t
Numerous fossil meteorites and high concentrations of sediment-dispersed extraterrestrial chromite (EC) grains with ordinary chondritic composition have previously been documented from 467 +/- 1.6 Ma Middle Ordovician (Darriwilian) strata. These finds probably reflect a temporarily enhanced influx of L-chondritic matter, following the disruption of the L-chondrite parent body in the asteroid belt
Effects of peptide hydrophobicity on lipid membrane binding, incorporation, and defect formation was investigated for variants of the complement-derived antimicrobial peptide CNY21 (CNYITELRRQHARASHLGLAR), in anionic 1-palmitoyl-2-oleoylphosphatidylethanolamine (POPE)/1-palmitoyl-2-oleoylphosphatidylglycerol (POPG) and zwitterionic 1-palmitoyl-2-oleoylphosphatidylcholine (POPC) membranes. Using a
L-DOPA-induced dyskinesia is a common side effect developed after chronic treatment with 3,4-dihydroxyphenyl-L-alanine (L-DOPA) in Parkinson's disease. The biological mechanisms behind this side effect are not fully comprehended although involvement of dopaminergic, serotonergic, and glutamatergic systems has been suggested. The present study utilizes in vivo amperometry to investigate the impact
Developing useful biological isoscapes for areas of the world is a priority. This is the case for Mexico that hosts a large percentage of North America's Neotropical migrant birds. Here we investigated the use of House Sparrow (Passer domesticus) feathers to create a spatially explicit feather deuterium isoscape for that country using samples (n=461) that were collected across Mexico. Considerable
