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Updated guidelines on the management of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) were released in 2021 by the American College of Rheumatology jointly with the Vasculitis Foundation and, subsequently, in 2022 by the European Alliance of Associations for Rheumatology. In addition, in 2021, the Kidney Disease: Improving Global Outcomes had released updated recommendatio

Single-photon emission computed tomography systems distinguish radionuclides by using multiple energy windows. For cadmium zinc telluride (CZT) detectors, the energy spectrum has a low-energy tail leading to additional crosstalk between the radionuclides. Previous work developed models to correct the scatter and crosstalk for CZT-based dedicated cardiac systems with similar 99mTc/123I tracer distr

This study investigates the effect of different mixers and the applicability of the mixing energy (ME) concept to dry powder formulations for inhalation. With the aim to step-wise build and expand this concept, adhesive mixtures of 2 % budesonide and lactose carrier were investigated, both with 1 % magnesium stearate (MgSt) added in a ‘coating’ step, and without, the latter referred to as ‘naked’

Objectives: A measurement tool to assess systematic reviews 2 (AMSTAR 2) was originally developed for systematic reviews (SRs) of health-care interventions. The aim of this study was to assess the applicability of AMSTAR 2 to SRs of non-intervention studies. Study design and setting: This was a meta-research study. We used 20 SRs for each of the following four types of SRs: Diagnostic Test Accurac

Stimuli-responsive polymers stand out for their ability to respond to small environmental changes. One of the most representative thermo-sensitive materials is poly(N-isopropyl acrylamide) (PNIPAm), which presents reversible phase transitions close to the human body temperature. However, previous studies observed that the copolymerization of NIPAm with small quantities of different monomers like a

For researchers studying wildlife distributions of the past, the assignment of faunal depictions and remains to species can often present considerable challenges. Regrettably, many studies do not systematically consider all options and sources of evidence and, as a result, questionable identifications are widespread in the literature, which compromises the trustworthiness of meta-analyses of human

In this study, we investigated the prevalence of mental disorders and the use of psychopharmacologic drugs among individuals with cerebral palsy (CP). We studied how the association between CP and mental illness develops over the life course (between ages 5 and 65 years), and how it varies across disability specific factors (intellectual disability, gross motor function and communicative ability).

Generating electricity from solar photovoltaics (PVs) has massive potential, but realising this potential will require a genuine understanding of transaction costs associated with the adopters' acquisition of the technology. The objective of this study is thus to empirically assess the transaction costs that solar PV adopters carry when proceeding with an acquisition process. Data on transaction c

Knock detection is critical for maintaining engine performance and preventing damage in spark-ignition engines. This study explores the use of ion current and knock indicators derived from a vibration sensor ((Formula presented.)) and ion current ((Formula presented.)) to improve knock detection accuracy. Traditional threshold-based methods rely on (Formula presented.), but they are susceptible to

One way of controlling global warming is to substitute fuel driven cars with electric cars. Electric vehicles need to be charged. For maximal efficiency the charging times should be as short as possible. In the US charging stations are classified as Level 1 charging 5–10 miles/h, Level 2 25 miles/h and Fast DCFC stations 150–1000 miles/h. We asked participants to select one of two upgrades of char

Introduction: Studies suggest that experiences of patient participation, as described by both patients and staff, are associated with a significant caring relationship of high quality. Aim: This study aimed to investigate staffs' and patients' self-reported perceptions on participation and the frequency and importance of verbal and social interactions in high-security forensic psychiatry. Method:

We have studied the development of phospholipase A2 (PLA2) and lysophosphatidylcholine (lysoPC)-metabolising enzyme activities in the neonatal rat intestine and its relation to the intestinal permeability of macromolecules. The permeability was determined by feeding young rats a mixture of bovine serum albumin, bovine immunoglobulin G and fluorescein-isothiocyanate-conjugated dextran 70,000, and a

Anthropogenic biodiversity decline threatens the functioning of ecosystems and the many benefits they provide to humanity 1. As well as causing species losses in directly affected locations, human influence might also reduce biodiversity in relatively unmodified vegetation if far-reaching anthropogenic effects trigger local extinctions and hinder recolonization. Here we show that local plant diver

Due to increasing plastic production, the continuous release of primary and secondary nanoplastic particles (NPs, <1 μm) has become an emerging contaminant in terrestrial environments. The fate and transport of NPs in subsurface environments remain poorly understood, largely due to the complex interplay of mineralogical, chemical, biological, and morphological heterogeneity. This study examines in

Background: Persistent non-plateauing adverse event rates in patients who underwent percutaneous coronary intervention (PCI) remain a challenge. A bioadaptor is a novel implant that addresses this issue by restoring the haemodynamic modulation of the artery, allowing cyclic pulsatility, vasomotion, and adaptative remodelling, by unlocking and providing dynamic support to the artery. We aimed to as

Character displacement theory predicts that closely-related co-occurring species should diverge in relevant traits to reduce costly interspecific interactions such as competition or hybridization. While many studies document character shifts in sympatry, few provide corresponding evidence that these shifts are driven by the costs of co-occurrence. Black-capped (Poecile atricapillus) and mountain c

This thesis will look at the profession of Town Planning from an economic perspective utilising New Institutional Economics (NIE) to focus on how different institutions and structures bring about trade- offs. As planning systems have considerable influence over property rights (the ability to affect one’s own lands) and over transaction costs by intervening in land markets, they are strongly conte

Just leave but feel free to come back: on the social services outreach work with people who renounce the need for help In this study I have been interested in the meetings that take place between outreach workers in social services and people who involuntarily are approached. More specifically, I have focused on the meetings with adult people who renounce the need for help from the outreach worke

In 2003 France introduced an ecologic protection zone off its Mediterranean coast. In that zone France has jurisdiction regarding environmental protection. This thesis will examine whether the zone is in conformity with existing international law and whether it was a necessary measure despite all the existing environmental protection in the Mediterranean Sea area. The thesis is structured as a com