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The association between white matter hyperintensities and executive decline in mild cognitive impairment is network dependent

White matter hyperintensities (WMH) in Mild Cognitive Impairment (MCI) have been associated with impaired executive functioning, although contradictory findings have been reported. The aim of this study was to examine whether WMH location influenced the relation between WMH and executive functioning in MCI participants (55-90 years) in the European multicenter memory-clinic-based DESCRIPA study, w

Picking personalities apart: estimating the influence of predation, sex and body size on boldness in the guppy Poecilia reticulata

Predation is a strong selective force in most natural systems, potentially fueling evolutionary changes in prey morphology, life history and behaviour. Recent work has suggested that contrasting predation pressures may lead to population differentiation in personality traits. However, there are indications that these personality traits also differ between sexes and not necessarily in a consistent

The nursing programme in the rear-view mirror. Interviews with Swedish nurses one year after their graduation

In order to increase the understanding of how students assimilate the knowledge they need to carry out their professional duties, knowledge about the experience of the nursing education in the light of the first year of employment is important. The aim of this study was to describe nurses' views of their education, one year after their graduation. Interviews with eight nurses, aged 24 to 40 years,

Characterization of the antennal olfactory system of the bed bug (Cimex lectularius)

The common bed bug Cimex lectularius (Hemiptera; Cimicidae) is a temporary ectoparasite on humans that is currently reinvading the developed countries. Like other haematophagous arthropods, host seeking and orientation in C. lectularius is partially mediated by olfaction. In this study, we reconfirmed the distribution of the 44 olfactory sensilla and identified 3 different sensillum types located

Evidence of concurrentlocal adaptation and high phenotypic plasticityin a polar microeukaryote.

Here we investigated whether there is evidence of local adaptation in strains of an ancestrallymarine dinoflagellate to the lacustrine environment they now inhabit(optimal genotypes) and/orif they have evolved phenotypic plasticity (a range of phenotypes). Eleven strains of Polarella glacialis were isolated and cultured from three different environments: the polar seas, ahyposaline,and a hypersali

Rationalisation in public dental care - impact on clinical work tasks and mechanical exposure for dentists - a prospective study

Swedish dentistry has been exposed to frequent rationalisation initiatives during the last half century. Previous research has shown that rationalisation often results in increased risk of developing work-related musculoskeletal disorders, thus reducing sustainability in the production system. In this prospective study, we assessed mechanical exposures among Swedish dentists in relation to specifi

Framing shared services Accounting, control and overflows

During the last decade there has been an increase in the use of horizontal organizational relationships (HORs) such as strategic alliances, shared services, and outsourcing. Studies accentuate the unstable, fragile nature of HORS and the importance of directing attention to how these arrangements are formed and how and why they change. The aim in this study is to explore control problems of HORs a

Loss- and gain-of-function analyses reveal targets of Pax6 in the developing mouse telencephalon.

Appropriate neurogenesis and patterning of the forebrain requires the transcription factor Pax6, yet it is largely unknown how Pax6 exerts its effects at the molecular level. To characterize Pax6-mediated regulation of gene expression during murine forebrain neurogenesis, we performed microarray analysis with tissue from the dorsal Pax6-dependent telencephalon and the ventral Pax6-negative telence

Quantitative detection of cell surface protein expression by time-resolved fluorimetry

A method is introduced for quantitative detection of cell surface protein expression. The method is based on immunocytochemistry, the use of long decay time europium(III) chelate and platinum(II) porphyrin labels, and detection of photoluminescence emission from adhered cells by time-resolved fluorimetry. After immunocytochemistry, the assay wells are evaporated to dryness and measured in the dry

Homozygosity for a null allele of SMIM1 defines the Vel-negative blood group phenotype.

The Vel antigen is present on red blood cells (RBCs) from all humans except rare Vel-negative individuals who can form antibodies to Vel in response to transfusion or pregnancy. These antibodies may cause severe hemolytic reactions in blood recipients. We combined SNP profiling and transcriptional network modeling to link the Vel-negative phenotype to SMIM1, located in a 97-kb haplotype block on c

Quantitative Genetic Effects of Bottlenecks: Experimental Evidence from a Wild Plant Species, Nigella degenii.

Understanding the genetic consequences of changes in population size is fundamental in a variety of contexts, such as adaptation and conservation biology. In the study presented here, we have performed a replicated experiment with the plant Nigella degenii to explore the quantitative genetic effects of a single-founder bottleneck. In agreement with additive theory, the bottleneck reduced the mean

Genetic diversity within and genetic differentiation between blooms of a microalgal species.

The field of genetic diversity in protists, particularly phytoplankton, is under expansion. However, little is known regarding variation in genetic diversity within populations over time. The aim of our study was to investigate intrapopulation genetic diversity and genetic differentiation in the freshwater bloom-forming microalga Gonyostomum semen (Raphidophyceae). The study covered a 2-year perio

Recruiting Agents in Industry and Trade - Lifting the Veil on Early People's Republic of China Operational Work

This paper concerns the operational activities of the public security organs of the People’s Republic of China (PRC) during the immediate post-1949 period of regime consolidation. The main part of the paper is a case-study of a 1950 pilot scheme to recruit agents in critical sectors of industry and trade in the city of Yingkou in Northeast China, a scheme in due course subsumed under a nationwide

Social Identity and Mobility at a Pre-industrial Mining Complex, Sweden

The early modern period has so far received little attention from archaeologists and anthropologists in Sweden. This study explores demographic patterns, social differences, family structure and mobility in a 16th-century skeletal population (n=102) from a preindustrial mining community (Salberget) in Bergslagen, Sweden, using a bioarchaeological perspective. Methodologically, the results of stron

Genotyping of human papillomavirus in triaging of low-grade cervical cytology.

OBJECTIVE: The objective of the study was to evaluate whether typing of human papillomavirus (HPV) among women with low-grade cervical cytology can improve the ability to identify women with cervical cancer or cervical intraepithelial neoplasia grade III (CIN III or worse). STUDY DESIGN: A total of 1595 women with low-grade cervical cytology participating in a randomized implementation trial of HP

The environmental context of a prehistoric rock carving on the Bjare Peninsula, Scania, southern Sweden

Palaeoecological analysis of peat deposits from a small bog at Lingarden, southern Sweden, have been used to examine the nature and timing of vegetation changes and anthropogenic activity associated with a nearby rock carving located close to the edge of the wetland. This study is the first of its type to investigate the environmental context of rock carvings in southern Sweden. Debate has tended

Concomitant medication of psychoses in a lifetime perspective

Objective Patients treated with antipsychotic drugs often receive concomitant psychotropic compounds. Few studies address this issue from a lifetime perspective. Here, an analysis is presented of the prescription pattern of such concomitant medication from the first contact with psychiatry until the last written note in the case history documents, in patients with a diagnosis of psychotic illness.

Freeze-thaw stability of mayonnaise type oil-in-water emulsions

In this paper, the freeze-thaw stability of mayonnaise type oil-in-water emulsions is studied. The emphasis of the experiments have been on the properties of the dispersed oil phase as only small, or no effects, were observed from initial experiments on changing the properties of the aqueous phase within the investigated ranges. Different vegetable oils are investigated in order to relate the comp

Male behaviour drives assortative reproduction during the initial stage of secondary contact.

Phenotypic divergence in allopatry can facilitate speciation by reducing the likelihood that individuals of different lineages hybridise during secondary contact. However, few studies have established the causes of reproductive isolation in the crucial early stages of secondary contact. Here we establish behavioural causes of assortative reproduction between two phenotypically divergent lineages o

Optimization of systems with the combination of ground-source heat pump and solar collectors in dwellings

The use of ground-source heat pumps for heating and domestic hot water in dwellings is common in Sweden. The combination with solar collectors has been introduced to reduce the electricity demand in the system. In order to analyze different systems with combinations of solar collectors and ground-source heat pumps, computer simulations have been carried out with the simulation program TRNSYS. Larg