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Background: Cerebral ischemia results in enhanced expression of contractile cerebrovascular receptors, such as endothelin type B (ETB), 5-hydroxytryptamine type 1B (5-HT1B), angiotensin II type 1 (AT(1)) and thromboxane (TP) receptors in the cerebral arteries within the ischemic area. The receptor upregulation occurs via activation of the mitogen-activated protein kinases (MAPK) pathway. Previous

Disperse dyes are the most common allergens among textile dyes. It is not known whether the purified dyes, impurities in the commercial dyes, or metabolites are the actual sensitisers. Moreover, it is not known whether those disperse dyes that are now present in test series are actually used in textile dyeing today. The aim of this thesis was A) to evaluate the significance of the impurities foun

Six glycoside hydrolase (GH) family 13 members, classified under the polyspecific neopullulanase subfamily GH13_20 (also termed cyclomaltodextrinase) were analysed. They originate from thermophilic bacterial strains (Anoxybacillus flavithermus, Laceyella sacchari, and Geobacillus thermoleovorans) or from environmental DNA, collected after in situ enrichments in Icelandic hot springs. The genes wer

Desiccation of the Sahara since the middle Holocene has eradicated all but a few natural archives recording its transition from a "green Sahara" to the present hyperarid desert. Our continuous 6000- year paleoenvironmental reconstruction from northern Chad shows progressive drying of the regional terrestrial ecosystem in response to weakening insolation forcing of the African monsoon and abrupt hy

Objective: This study evaluated the tolerability and efficacy of inhaled AZD4818, a CCR1 antagonist, in patients with COPD. Methods: This double-blind, placebo-controlled study (NCT00629239) randomised patients with moderate to severe COPD to AZD4818 300 mu g or placebo twice daily via Turbuhaler (R) for 4 weeks. Safety, lung function, functional capacity and health status measures were measured.

The effect of three different types of polymer chain structures on the polymer release from hydrophilic matrix tablets was investigated by comparing a synthetic semi-crystalline linear polymer (PEO), a branched amorphous polysaccharide (dextran) and an amorphous substituted cellulose derivative (HPMC). The polymer release rates for tablets containing mixtures of high and low molecular weight grade

This study (N=37 with high, medium, and low hyp-notizables) evaluated depth reports and EEG activity during both voluntary and hypnotically induced left-arm lifting with sLORETA functional neuroimaging. The hypnotic condition was associated with higher activity in fast EEG frequencies in anterior regions and slow EEG frequencies in central-parietal regions, all left-sided. The voluntary condition

The photodissociation dynamics of CH2ICH2I, CF2ICF2I, and CF2BrCF2I have been studied in solution after excitation at 266 nm. Formation of I-2 is apparent within tens of picoseconds in solutions of CH2ICH2I and CF2ICF2I in acetonitrile. but not from CF2BrCF2I, More I-2 is formed from CH2ICH2I rather than from CF2-ICF2I, as expected if the 12 formation is a result of secondary dissociation of the h

This study sought to elucidate Swedish pediatric wards concerning the practice of informing children and their parents about clinical examinations and procedures. A semi-structured questionnaire was distributed to all 36 pediatric departments in Sweden, comprising of 83 wards. Fifty-eight (70%) of the wards responded. The results showed that 55 (95%) of the wards provided regular planned informati

Serotonin, a highly pro-inflammatory molecule released by activated platelets, is formed by tryptophan. Tryptophan is also needed in the production of kynurenine, a process mediated by the type I interferon (IFN)-regulated rate-limiting enzyme indoleamine 2,3-dioxygenase (IDO). The aim of this study was to investigate levels of serotonin in patients with the autoimmune disease systemic lupus eryth

Popular Abstract in Swedish Under 1900-talets inledande decennier genomfördes fältarbeten på den svenska landsbygden då äldre bebyggelse och byar dokumenterades på bild och i ord. Dessa dokumentationer ingick i ett större sammanhang, där ambitionen var att alla aspekter av en förmodat försvinnande allmogekultur skulle kartläggas, samlas in och arkiveras. By- och bebyggelsedokumentationerna utförde

The goal of this article is to examine what role literature played for Nicolae Ceaușescu, Romania's political leader between 1965 and 1989. I focus on the period between 1968 and 1974, when the basis was laid for a cultural policy which was to be applied until the end of Ceaușescu's reign in 1989. Such studies are easier to conduct today, when the archives of the Romanian Communist Party have been

Three zeaxanthin homologues with conjugation lengths N of 15, 19, and 23 denoted as Z15, Z19, and Z23 were studied by femtosecond transient absorption spectroscopy, and the results were compared to those obtained for zeaxanthin (Z11). The energies of S2 decrease from 20 450 cm(-1) (Z11) to 18 280 cm(-1) (Z15), 17?095 cm(-1) (Z19), and 16?560 cm(-1) (Z23). Fitting the N dependence of the S-2 energi

This paper describes a novel approach to the quantitative investigation of the impact of varying relative humidity (RH) and temperature on the structure and thermodynamic properties of salts and crystalline cement hydrates in different hydration states (i.e. varying molar water contents). The multi-method approach developed here is capable of deriving physico-chemical boundary conditions and the t

In this paper public participation in Swedish municipal traffic planning is studied with the focus onto what extent and how municipalities and consultants interact with participants in traffic-planning processes. Telephone interviews with planners were performed and planners' insight and knowledge of participation methods are analysed in order to give an indication of which prerequisites seem to d

Background: In 2007, the World Cancer Research Fund (WCRF) and the American Institute for Cancer Research (AICR) issued recommendations on diet, physical activity, and weight management for cancer prevention on the basis of the most comprehensive collection of available evidence. Objective: We investigated whether concordance with WCRF/AICR recommendations is related to risk of death. Design: The

A search for squarks and gluinos in events containing jets, missing transverse momentum and no electrons or muons is presented. The data were recorded in 2011 by the ATLAS experiment in root s = 7 TeV proton-proton collisions at the Large Hadron Collider. No excess above the Standard Model background expectation is observed in 1.04 fb(-1) of data. Gluino and squark masses below 700 GeV and 875 GeV