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Popular Abstract in Swedish Vårt immunsystem består av ett nätverk av olika sorters celler och molekyler, vars uppgift är att försvara oss mot patogener (sjukdomsalstrande organismer) som till exempel virus och bakterier, medan det samtidigt måste tolerera proteiner och ämnen som finns naturligt i vår kropp. Immunsystemet kan delas upp i två delar; det medfödda (eller ospecifika) och det adaptiva Mucosal tissues such as the intestine present an enormous surface area to the outside environment and are continually exposed to foreign antigens in food and microflora. Thus, the intestinal mucosa must must remain tolerant to these innocuous antigens while at same time be able to mount effective immune responses to pathogens. Intestinal dendritic cells (DCs) and macrophages, found throughout the

We here present the first genetic fine mapping of experimental autoimmune neuritis (EAN), the animal model of Guillain-Barre syndrome, in a rat advanced intercross line. We identified and refined a total of five quantitative trait loci on rat chromosomes 4, 10, and 12 (RNO4, RNO10, RNO12), showing linkage to splenic IFN-gamma secretion and disease severity. All quantitative trait loci were shared

Making a detour can be advantageous to a migrating bird if fuel-deposition rates at stopover sites along the detour are considerably higher than at stopover sites along a more direct route. One example of an extensive migratory detour is that of the Sharp-tailed Sandpiper (Calidris acuminata), of which large numbers of juveniles are found during fall migration in western Alaska. These birds take a

Tasquinimod is an orally active antiangiogenic drug that is currently in phase III clinical trials for the treatment of castration-resistant prostate cancer. However, the target of this drug has remained unclear. In this study, we applied diverse strategies to identify the histone deacetylase HDAC4 as a target for the antiangiogenic activity of tasquinimod. Our comprehensive analysis revealed allo

Context:Patients with treated adrenal insufficiency (AI) have increased morbidity and mortality rate. Our goal was to improve outcome by developing a once-daily (OD) oral hydrocortisone dual-release tablet with a more physiological exposure-time cortisol profile.Objective:The aim was to compare pharmacokinetics and metabolic outcome between OD and the same daily dose of thrice-daily (TID) dose of

There is a mounting effort to use nickel oxide (NiO) as p-type selective electrode for organometal halide perovskite-based solar cells. Recently, an overall power conversion efficiency using this hole acceptor has reached 18%. However, ultrafast spectroscopic investigations on the mechanism of charge injection as well as recombination dynamics have yet to be studied and understood. Using time-reso

Projekt Turnstone är ett samverkansprojekt delvis finansierat av Europeiska kommissionen. Projektet är ett initiativ av Stockholmspolisens gränsbevakningsenhet. Syftet med Projekt Turnstone är att minska gränsöverskridande brottslighet, förbättra dagligt samarbete mellan gräns, polis och kustbevakare i Östersjöregionen och förbättra säkerheten för passagerare i Östersjöregionen utan att göra avkalProject Turnstone is a collaborative project funded in part by the European Commission. The project is an initiative by the Stockholm Police. The purpose of the project is to improve day-to-day cooperation between border officers in the Baltic Sea region, decrease trans-boundary criminality, and increase security for passengers in the Baltic Sea area without compromising freedom of movement. Withi

Chemotaxis inhibitory protein of Staphylococcus aureus (CHIPS) is a protein that binds and blocks the C5a receptor (C5aR) and formylated peptide receptor, thereby inhibiting the immune cell recruitment associated with inflammation. If CHIPS was less reactive with existing human antibodies, it would be a promising anti-inflammatory drug candidate. Therefore, we applied directed evolution and comput

Physical activity is beneficial for the health of persons with disabilities but the levels of such activity are lower than for persons without disability. In addition the level of physical activity decreases with increasing age. For persons aging with a disability it may be a challenge to engage in physical activity, partly because of the disability and partly because of contextual barriers. One g

Background: Degraded extracellular matrix can stimulate the innate immune system via the Toll-Like Receptor-4 (TLR4). In the pancreas, syndecan-anchored heparan sulphate (HS) on the ductal epithelium can be cleaved off its protein cores by the proteases (trypsin and elastase) and potentially activate TLR4 signalling. Methods: To investigate this signalling event, a low sulphated HS (500 mu g/ml) w

The word “desertification” was introduced in 1949 by the French scientist Aubreville in his report “Climats, forêts et désertification de l´Afrique tropicale”. The concept, however, was discussed earlier by European and American scientists in terms of increased sand movements, desiccation, desert and Sahara encroachment and man made deserts. Desertification, at the beginning of last century, mea

The purpose of this study was to examine the impact of the parent training The Incredible Years in clinical settings. The study included 33 families in clinical practice. There were two parts to the study; a main part with a before and after measurement, and a follow-up study on 12 children one year later. On baseline the children (3-9 years) as a group were on the borderline clinical range, (M =

The aim of this study is to analyze the construction of "Christian masculinity" during the modern era. This is made in opposition to earlier research that has claimed that masculinity could not be constructed religiously, that is, without at the same time being constructed as effeminate or anti-masculine. Using a wide variety of theoretical concepts - such as discourse analysis, class,

Allergic rhinitis is an inflammatory nasal disorder in which a range of different cells participates. A variety of approaches has been used to monitor nasal inflammation objectively to investigate disease processes and to evaluate the effect of therapeutic intervention. These approaches include nasal lavage, nasal cytology, and nasal biopsy, together with the more recently established measurement

The presence of metal resistance determinants in bacteria usually is attributed to geological or anthropogenic metal contamination in different environments or associated with the use of antimicrobial metals in human healthcare or in agriculture. While this is certainly true, we hypothesize that protozoan predation and macrophage killing are also responsible for selection of copper/zinc resistance

Heteroclitic monoclonal antibodies are characterized by the ability to bind multiple epitopes with little or no similarity. Such antibodies have been reported earlier, but insight into to the molecular basis of this propensity is limited. Here we report that the KIM185 antibody to human CD18 reacts with the plasma protein C4b-binding protein (C4BP). This was revealed during affinity purification p

Popular Abstract in Swedish Sammanfattning I debatter och forskning om narkotikapolitik anges den svenska och nederländska modellen ofta som ett motsatspar. Såväl målet för, som utformningen av, narkotikapolitiken har framställts som radikalt olika. Detta synsätt kan sägas vara riktigt. Målet för den svenska narkotikapolitiken är att skapa ett narkotikafritt samhälle. Den nederländska strävar efteIn debates about the Swedish and Dutch drug policies are usually positioned as opposites. The goal for the Swedish drug policy is to create a 'drug-free society'; while in the Netherlands a harm reduction approach prevails. In this study a drug policy is considered a practice of formal social control that can develop differently depending on the contexts in which it emerged. The period studied sta

Context:The cardiac natriuretic peptides are involved in blood pressure regulation, and large cross-sectional studies have shown lower plasma levels of N-terminal pro-natriuretic peptide levels [N-terminal atrial natriuretic peptide (N-ANP) and N-terminal brain natriuretic peptide (N-BNP)] in patients with insulin resistance, obesity, and diabetes.Objective:In this study, we prospectively tested w