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Photoinduced electron transfer between a carotenoid and TiO2 nanoparticle

The dynamics of photoinduced electron injection and recombination between all-trans-8'-apo-beta-caroten-8'-oic acid (ACOA) and a TiO2 Colloidal nanoparticle have been studied by means of transient absorption spectroscopy. We observed an ultrafast (similar to360 fs) electron injection from the initially excited S-2 state of ACOA into the TiO2 conduction band with a quantum yield of similar to40%. A

Molecular mapping of the Goodpasture's epitope for glomerulonephritis

Goodpasture's syndrome is an autoimmune disease characterized by pulmonary hemorrhage, glomerulonephritis, and antiglomerular basement membrane (GBM) antibodies. We have studied a rat model with chimeric proteins (CPs) consisting of portions of the nephritogenic non-collagenous domain of alpha3 type IV collagen (alpha3(IV)NC1) and non-nephritogenic alpha1(IV)NC1. CPs with aminoterminal alpha3 that

Spectroscopic data for Hg I and Hg II from beam-foil spectroscopy

The spectroscopic data mercury (Hg) I and Hg II was analyzed from beam-foil spectroscopy. The wavelength was found to be of course fixed and independent of the light source and recording conditions. It was found that if the calculated branching ratio was correct, then the Hg II was an important constituent of fluorescent light tube plasmas. The wavelength region from 40 to 600 nm in overlapping wa

HAMLET - In vivo effects and mechanisms of tumor-cell death

Popular Abstract in Swedish Ämnen i bröstmjölk kan få cancerceller att begå självmord - in vivo effekter och mekanismer för celldöd Sedan länge är det känt att bröstmjölk skyddar det ammande barnet mot infektioner och hjälper till att bygga upp des's immunförsvar. Ett skyddande ämne som kan bilda's av molekyler från bröstmjölk är HAMLET (human alpha-lactalbumin made lethal to tumor cell's), som kHAMLET (human alpha-lactalbumin made lethal to tumor cells), a molecular complex derived from human milk, is an interesting new tool in cancer research since it induces programmed cell death in tumor cells while leaving normal, differentiated cells unharmed. The in vivo effects of HAMLET were studied in a rat xenograft model of human glioblastoma. HAMLET reduced the tumor volume and delayed the o

Properties of long gamma-ray bursts from massive compact binaries.

We consider the implications of a model for long-duration gamma-ray bursts in which the progenitor is spun up in a close binary by tidal interactions with a massive black-hole companion. We investigate a sample of such binaries produced by a binary population synthesis, and show that the model predicts several common features in the accretion on to the newly formed black hole. In all cases, the ac

Into the isle of self : Nietzschean patterns and contrasts in D.H. Lawrence's The trespasser

This thesis is based on a close reading of Lawrence's novel The Trespasser from a Nietzschean point of view. By adopting this perspective it aims at giving the novel the sense of unity it has so far been alleged to lack. The analysis is preceded by a detailed discussion of the concept of literary influence. Since the purpose of this study is to illuminate what is unique in Lawrence's novel rather

A force allocation strategy for dynamic positioning

A force allocation strategy used in connection with dynamic positioning of ships and semi-submersibels is presented. The strategy dynamically allocates force, and in case of azimuth thrusters - force directions, to a set of thrusters. The strategy handles n thrusters (n greater than or equal to 2) in an arbitrary configuration. The decision making of the strategy is based on minimum power consumpt

Cinema in the Welfare State : Notes on Public Support, Regional Film Funds, and Film Policy in Swedish Film

The present article will place recent Swedish cinema against the background of the evolving public film policy and support – transnational, national and regional – during the last five decades. Particular emphasis will be put on the period since the mid-1990s. Accordingly, a brief presentation and critical analysis of various important aid bodies like the Swedish Film Institute (SFI), the Nordisk

The role of P fimbriae for Escherichia coli establishment and mucosal inflammation in the human urinary tract

Popular Abstract in Swedish Infektioner i urinvägar, tarm och luftvägar orsakas av bakterier som speciellt anpassats till respektive vävnad. Infektionen börjar med att bakterien binder till slemhinneytan, och därmed sätter igång inflammation och försvar. Urinvägsinfektioner (UVI) är en värdefull modell för att förstå de molekylära detaljerna som avgör balansen mellan värd och bakterie. UVI orsakaBacterial adhesion to the bladder mucosa is a critical step for the establishment of Escherichia coli bacteriuria. The P-fimbriae, encoded by the pap gene cluster, are considered as virulence factors but the mechanisms have been debated. This study defined the roles for P fimbriation during the early colonization of the human urinary tract. Patients with recurrent UTI were first subjected to deli

Understanding software processes through system dynamics simulation: a case study

This paper presents a study with the intent to examine the opportunities provided by creating and using simulation models of software development processes. A model of one software development project was created through means of system dynamics, with data collected from documents, interviews and observations. The model was simulated in a commercial simulation tool. The simulation runs indicate th

The Rockox' Mables

A number of Roman Marble heads in Swedish Royal possession since the 17th century may be traced back to the collection of the burgomaster Rockox in Antwerpen. Four of these occur in the famous painting by Frans Francken the Younger representing a feast in Nicholaas Rockox' home. Althoug more marble heads to be found in the Stockholm collection may be traced back to Rockox two of the heads in the p

Stability and change in the development of knowledge

This contribution is about an entirely new approach to the study of knowledge. As an introductory remark, the classical research operations in the field of cognition are reviewed. Against this background, an application of David Hestenes theory of rotational dynamics is demonstrated with particular reference to text processing. Based on the mechanism of joints and links of the AaO machine, angular

Spaces of urbanity. From the village square to the boulevard

Urbanism is much more than simply an agglomeration of houses : it is a particular way of living space. Our considerations starts out from some of the historically prominent figures of urbanity, such as the market-place, the boulevard and the coffee house. Semiotics of space may either involve a certain number of elementary building-blocks being combined in particular ways, much as language is ; or

On the Efficient Estimation of Blood Velocities

Pulsed wave (PW) Doppler ultrasound systems are commonly used to examine blood flow dynamics and the technique plays a very important role in numerous diagnostic applications. Commonly, narrow-band PW systems estimate the blood velocity using an autocorrelation-based estimator. Herein, we examine a recently proposed hybrid frequency estimator, and via extensive numerical simulations using simulate

HAMLET kills tumor cells by an apoptosis-like mechanism--cellular, molecular, and therapeutic aspects.

HAMLET (human α-lactalbumin made lethal to tumor cells) is a protein-lipid complex that induces apoptosis-like death in tumor cells, but leaves fully differentiated cells unaffected. This review summarizes the information on the in vivo effects of HAMLET in patients and tumor models, on the tumor cell biology, and on the molecular characteristics of the complex. HAMLET limits the progression of hu

A folding variant of human alpha-lactalbumin induces mitochondrial permeability transition in isolated mitochondria

A human milk fraction containing multimeric alpha-lactalbumin (MAL) is able to kill cells via apoptosis. MAL is a protein complex of a folding variant of alpha-lactalbumin and lipids. Previous results have shown that upon treatment of transformed cells, MAL localizes to the mitochondria and cytochrome c is released into the cytosol. This is followed by activation of the caspase cascade. In this st