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Multimeric lactosides based on carbohydrate scaffolds with valencies ranging from 1 to 4 and different linker lengths were synthesized by a copper-catalyzed azide-alkyne cycloaddition (CuAAC). The binding affinities and crosslinking abilities of the new "click clusters" toward biologically relevant galectins (gal-1, gal-3) and peanut lectin were evaluated by fluorescent polarization assay (FPA) an

HAMLET, a complex of α-lactalbumin and oleic acid, preferentially kills cancer cells and is also effective in vivo. HAMLET causes apoptosis but cells die even if this pathway is inhibited. Thus, the role of autophagy, an alternative cell death pathway, was examined. During autophagy double membrane-enclosed autophagosomes form around cellular material and deliver it to the lysosomes for degradatio

Controlled vocabularies (CVs), i.e. a collection of predefined terms describing a modeling domain, used for the semantic annotation of data, and ontologies are used in structured data formats and databases to avoid inconsistencies in annotation, to have a unique (and preferably short) accession number and to give researchers and computer algorithms the possibility for more expressive semantic anno

Popular Abstract in Swedish Våra celler är täckta av kolhydrater (socker) som är kopplade till proteiner och lipider på cellens yta. Olika celler presenterar olika socker, och en och samma cell kan dessutom ändra sitt sockeruttryck beroende på hur den mår och vad den vill utföra, till exempel dela sig eller dö, en effekt man ofta ser i cancer. På så sätt fungerar sockerstrukturerna som en kod som There is an intensive interest in characterising the structure and function of galectins, which is not surprising given their many important cellular functions and strong implications in human disease. Understanding the mechanisms involved in galectin functions will help to find selective and novel strategies for disease treatment and diagnosis. A key to this lies in their carbohydrate binding spe

Are voiceless approximants categorically distinct from voiceless fricatives? We address this question by means of acoustic analysis of voiceless laterals in Icelandic, Welsh, and the endangered variety Estonian Swedish. All three have a voiceless lateral functioning in contrast to a voiced lateral approximant. The analysis focused on duration – including any period of voicing (‘pre-voicing’) just

The recent progress in our work to implement salt (NaCl) as a dosemeter is presented. Laboratory investigations have indicated a linear dose response from 1 mGy to about 100 mGy and detection limits down to 0.1 mGy. Investigations in the clinic comparing TL-dosimetry in LiF and OSL in NaCl have indicated a similar dose response for the two dosemeters at different photon energies. Field studies wit

The infrared spectrum of water, isolated in inert matrices, has been studied in the interval from 60 to 4000 cm(-1). Experiments with partially deuterated water combined with DFT (density functional theory) calculations have been used to investigate the structure of matrix-isolated water tetramer. A few, strong intermolecular fundamentals of the water tetramer have been observed. Mid-infrared band

Proteus mirabilis bacilli play an important role in human urinary tract infections, bacteremia, and rheumatoid arthritis. The authors previously studied human complement C3 conversion by smooth-form P. mirabilis O10, O23, O30, and O43 lipopolysaccharides (LPSs) and showed that smooth Proteus LPSs fragmented C3 in a dose- and time-dependent manner. In the present study, one smooth P. mirabilis S195

We are living in a highly dynamic, human-dominated Earth System in which non-linear, abrupt and irreversible changes are not only possible but also probable. These changes require institutional structures capable of steering human society away from critical tipping points and irreversible change and ensuring sustainable livelihoods for all. We see 2012 as a charter moment, a historic opportunity t

The molecular mechanism responsible for the antitumor activity of histone deacetylase inhibitors (HDACi) remains elusive. As HDACi have been described to alter miRNA expression, the aim of this study was to characterize HDACi-induced miRNAs and to determine their functional importance in the induction of cell death alone or in combination with other cancer drugs. Two HDACi, trichostatin A and vori

‘The Nurse in Primary Health Care with Special Focus on Child Health Care’ The function of nurses in Swedish primary care involves health care and medical care for people of all ages, and in their health-promotion work there is a focus on child health care. Child health care in Sweden is mostly provided by nurses. The work encompasses all children from birth to school age; it is voluntary and fre

During atrial fibrillation (AF), time-frequency analysis of atrial signal has been applied to describe fibrillatory frequency trends. Recently, temporal changes in spectral shape have been investigated using the spectral profile technique. This profile is computed recursively by fitting each short-time log-spectrum to a spectral template, using amplitude scaling and frequency shifting. The purpose

The concentrations of water dimer are compared in Ne and p-H-2 matrices at low temperatures, using infrared spectroscopy. Additional data are given for o-D-2 and Ar matrices. For a given monomer concentration, the dimer concentration is significantly higher in solid Ne (or Ar) than in solid p-H-2. In p-H-2, the dimer concentration is only slightly higher than expected for a random distribution of

Aktuell status för dagvattenhantering i grannstäderna Köpenhamn och Malmö studerades med avseende på befintliga åtgärder och genomförda systemen i de båda städerna. Tillämpning av blå-gröna lösningar i de yttre delarna av Malmö började på 1990-talet och följaktligen är samarbete mellan olika avdelningar inom kommunen mer strukturerat i Malmö medan processen i Köpenhamn fortfarande är baserad på trThe current status of storm-water management in the neighbor cities of Copenhagen and Malmö was studied with respect to present measures and the implemented systems in both cities. Application of blue-green solutions in the outer parts of Malmö started in the 1990s; hence collaboration between different departments in the municipality is more structured in the city of Malmö while in Copenhagen the

Brachytherapy treatment techniques for cancer of the cervix are presented, with examples based on the "Stockholm" technique.

Natural food webs are embedded in a variable environment, which causes population densities to fluctuate, despite a potential stable equilibrium. Population interactions as well as the characteristics of the environmental fluctuations determine the resulting population dynamics. Populations sensitive to the same kind of environmental disturbances will show correlated responses in their respective