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The International Active Learning Space

For me, internationalisation is a learning outcome, not just about international mobility. It is about ensuring that students actively participate in a learning experience that prepares them for a world that is more and more internationally and interculturally connected - that both Danish and non-Danish students receive the basic international and intercultural skills and knowledge they need in cu

Nordics in Motion : Transimperial Mobilities and Global Experiences of Nordic Colonialism

This special issue investigates Nordic individuals in transimperial spaces. It tracks Nordics on the move from the early modern period to the twentieth century, as they crossed imperial boundaries, and connected, networked, and operated in different spaces around the world within the framework of European global expansion. Though coming from countries with few or no formal colonies of their own, N

Introduction : Digital Methods and Experiential Approaches to the Past

In this chapter, the authors introduce the theme of computational/digital methods in the realm of sensory archaeologies. To this purpose, the concept of sensoriality and its relevance for the archaeological discourse is rediscussed. Key concepts such as perception of material culture help us in better defining possible modalities through which archaeologists can benefit from the use of formal meth

Does fatigue in Parkinson’s disease impact one’s physical function in daily live?

Objective: To investigate fatigue at baseline and 3.5 years later and its association with balance and gait over time.Background: In Parkinson’s disease (PD), fatigue is considered one of the most common and disabling nonmotor symptoms that may persist or even worsen over time. Fatigue in generally has been described as a significantly diminished energy level or an increased perception of effort d

Historical trends in calls to action : Climate change, pro-environmental behaviours and green social work

Social works’ relationship with the environment and the role of social workers in addressing environmental issues under climate change are usually neglected in mainstream practice. I begin this chapter by discussing the importance of social work as a field of research and practice that needs to actively carve out a position of expertise and engagement with emerging environmental issues at the micr

Sphingomyelin, glycosphingolipids, and ceramide signalling in cells exposed to p-fimbriated Escherichia coli

Uropathogenic Escherichia coli attach to epithelial cells through P fimbriae that bind Galα1‐4Galβ‐oligosaccharide sequences in cell surface glycosphingolipids. The binding of P‐fimbriated E. coli to uroepithelial cells causes the release of ceramide, activation of the ceramide signalling pathway and a cytokine response in the epithelial cells. The present study examined the molecular source of ce

Purification and characterization of radiolabelled biosynthetic human insulin from Escherichia coli kinetics of processing by antigen presenting cells

An Escherichia coli strain transfected with a plasmid containing four linked human proinsulin genes was grown in the presence of 35S and 3H labelled amino acids to gain access to human insulin that was radiolabelled at 19 evenly distributed sites throughout the amino acid sequence. The multi-proinsulin precursor was cleaved at methionine residues with cyanogen bromide, then the individual proinsul

Master protocols in clinical trials : a universal Swiss Army knife?

Master protocols combine several sub-trials, each with their own research objectives, which is usually presented as one single clinical trial application. Master protocols have become increasingly popular in oncology and haematology, as either basket, umbrella, or platform trials. Although master protocols are intended to accelerate drug development and to reduce futility, their use poses challeng

An investigation of enzymatic kinetic resolution of racemic clopidogrel

This paper presents a biocatalysis based approach for asymmetric hydrolysis of Clopidogrel, one of the most effective antiplatelet aggregators. Instead of the conventional "wet lab" screening method, we used an advanced chemical information retrieval tool, Scifinder®, to find suitable enzyme candidate(s) for the asymmetric hydrolysis. Scifinder® search for reactions similar to the target reaction

HER-2/neu and INT2 proto-oncogene amplification in malignant breast tumors in relation to reproductive factors and exposure to exogenous hormones

In previous studies in southern Sweden, early use of oral contraceptives has been found to be accompanied by an increased risk of developing premenopausal breast cancer, and the tumors developing in these patients have shown a more aggressive behavior. In the present study, amplification of the proto-oncogenes Her-2/neu (also known as ERBB2) and INT2 was studied in primary tumor specimens from 72