Filtyp
Obesity is considered by many as a lifestyle choice rather than a chronic progressive disease. The Innovative Medicines Initiative (IMI) SOPHIA (Stratification of Obesity Phenotypes to Optimize Future Obesity Therapy) project is part of a momentum shift aiming to provide better tools for the stratification of people with obesity according to disease risk and treatment response. One of the challeng
Model Hamiltonians are regularly derived from first principles to describe correlated matter. However, the standard methods for this contain a number of largely unexplored approximations. For a strongly correlated impurity model system, here we carefully compare a standard downfolding technique with the best possible ground-truth estimates for charge-neutral excited-state energies and wave functio
Breast cancer is the most frequently diagnosed cancer in females globally. However, we know relatively little about trends in males. This study describes United Kingdom (UK) secular trends in breast cancer from 2000 to 2021 for both sexes. We describe a population-based cohort study using UK primary care Clinical Practice Research Datalink (CPRD) GOLD and Aurum databases. There were 5,848,436 elig
Partitioned polygenic scores (pPS) have been developed to capture pathophysiologic processes underlying type 2 diabetes (T2D). We investigated the association of T2D pPS with diabetes-related traits and T2D incidence in the Diabetes Prevention Program. We generated five T2D pPS (b-cell, proinsulin, liver/lipid, obesity, lipodystrophy) in 2,647 participants randomized to intensive lifestyle, metfor
This paper presents a detector developed to protect the ESS spallation target. The detector is installed to receive a proton beam that has a peak current of 62.5 mA, an average power of 5 MW, and energy up to 2 GeV. It is designed to detect any part of the proton beam that goes outside a defined aperture, which is deemed as an errant beam condition. This detector is mainly used for machine protect
BACKGROUND: De novo oligometastatic prostate cancer (omPCa) on prostate-specific membrane antigen (PSMA) positron emission tomography (PET) is a new disease entity and its optimal management remains unknown. OBJECTIVE: To analyze the outcomes of patients treated with cytoreductive radical prostatectomy (cRP) for omPCa on PSMA-PET. DESIGN, SETTING, AND PARTICIPANTS: Overall, 116 patients treated wi
Second-order phase transitions appear as a divergence in one of the linear response functions. For a system of correlated electrons, the relevant divergent response can and does involve many-particle observables, most famously the double occupancy. Generally, evaluating the linear response function of many-particle observables requires a many-particle generalization of the Bethe-Salpeter equation.
Near-field focusing (NFF) is a fundamental enabler for a broad spectrum of applications utilizing large intelligent surfaces (LIS) within sub-10 GHz frequency bands. This paper investigates the impact of element pattern on NFF properties, when the LIS array is a large planar array. The NFF properties of maximum received power, focal width, and focal depth are analyzed for three typical antenna pat
The rise of 5G technology leads to a boom in the demand for widely available wireless connectivity while requiring telecommunication networks to improve spectral efficiency and deploy dynamic spectrum sharing (DSS) and carrier aggregation (CA). This imposes more stringent intermodulation test scenarios and blocking requirements on RF transceivers. In addition, they are required to be programmable
Aims/hypothesis: Sleep, diet and exercise are fundamental to metabolic homeostasis. In this secondary analysis of a repeated measures, nutritional intervention study, we tested whether an individual’s sleep quality, duration and timing impact glycaemic response to a breakfast meal the following morning. Methods: Healthy adults’ data (N = 953 [41% twins]) were analysed from the PREDICT dietary inte
Construction using timber has seen a resurgence in light of global climate mitigation policies. Wood is a renewable resource, and engineered wood products are proving to be competitive against concrete and steel while having several advantages. However, while the renewable nature of wood in construction is a beneficial property for climate mitigation policies, the process of biodegradation introdu
Finger tapping to isochronous pacing stimuli is a well established experimental paradigm first described in the late 19th century. Two variables of common interest in rhythmic tapping tasks are timing variability and constant error. However, a difficulty when estimating these variables is that at interstimulus intervals longer than 2 seconds participants regularly overshoot the target interval and
We report on a new nanopatterned structure represented by a single atomic layer of hexagonal boron nitride (h-BN) forming long periodic waves on the Fe(110) surface. The growth process and the structure of this system are characterized by X-ray absorption (XAS), core-level photo-emission spectroscopy (CL PES), low-energy electron microscopy (LEEM), microbeam low-energy electron diffraction (mu LEE
Popular Abstract in Swedish Denna avhandling är resultatet av mitt doktorandarbete vid Kvartärgeologiska avdelningen, Geologiska institutionen, Lunds universitet. Avhandlingen baseras på resultaten av fältarbeten i ett antal lokaler i ett område väster om sjön Bolmen i sydvästra Sverige. Introduktion och bakgrund Weichselistidens recession från södra Sverige har diskuterats av olika geologer undeThe Late Weichselian deglaciation of an area in southwestern Sweden was reconstructed by geomorphological, sedimentological and lithostratigraphical methods. The morainic deposits were mapped and classified into three landsystems: Streamlined terrain, hummocky moraine and cover moraine. Streamlined terrain was assumed to have been formed subglacially by a wet-based ice sheet. Cover moraine was int
Husserlian phenomenological theory is offered as an integrated and integrating for an understanding of management decision making and related issues in work and organizational sciences. The aspects of meaning, meaning constitution, subjective processes, and perspectives, mutual understanding of each other´s perspective, individuals as horizons of possible worlds are central to this conception, mak
The formation of acrylamide in potato crisps was fitted by empirical mathematical models. Potato slices were fried under the same experimental conditions for different times. Besides the content of precursors in the raw potato slices, acrylamide and water content in the potato crisps were quantified after predetermined times (2-6 min). The temperature developments in the surrounding oil and outer
Popular Abstract in Swedish In conclusion we show that basement membrane components are present in cartilage ECM and that they may serve roles both as BM functional equivalents as well as organizational roles during ECM formation. Den extracellulära matrixen (ECM) är ett nätverk av makromolekyler som, tillsammans med celler, bildar de olika vävnaderna I alla organismer från phylum metazoa. Till sThe extracellular matrix (ECM) is a network of macromolecules which, together with cells, forms the various tissues of all metazoan organisms. Cartilage, in contrast to most other tissues, contains relatively few cells in proportion to the volume occupied by ECM. Part of this work involves investigation of cartilage ECM for expression and secretion of proteins that are considered to be the definin
Background: Radical prostatectomy reduces mortality among patients with localised prostate cancer. Evidence on whether different surgical techniques can affect mortality rates is lacking. Objective: To evaluate functional and oncological outcomes 8 yr after robot-assisted laparoscopic prostatectomy (RALP) and open retropubic radical prostatectomy (RRP). Design, setting, and participants: We enroll
The complex genetic architecture of type-2-diabetes (T2D) includes gene-by-environment (G×E) and gene-by-gene (G×G) interactions. To identify G×E and G×G, we screened markers for patterns indicative of interactions (relationship loci [rQTL] and variance heterogeneity loci [vQTL]). rQTL exist when the correlation between multiple traits varies by genotype and vQTL occur when the variance of a trait
