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STUDY QUESTION: Has cumulative live birth rate (CLBR) improved over time and which factors are associated with such an improvement? SUMMARY ANSWER: During an 11-year period, 2007-2017, CLBR per oocyte aspiration increased significantly, from 27.0% to 36.3%, in parallel with an increase in blastocyst transfer and cryopreservation by vitrification. WHAT IS KNOWN ALREADY: While it has been shown that

Clustering multiple motions from observed point trajectories is a fundamental task in understanding dynamic scenes. Most motion models require multiple tracks to estimate their parameters, hence identifying clusters when multiple motions are observed is a very challenging task. This is even aggravated for high-dimensional motion models. The starting point of our work is that this high-dimensionali

This work addresses the design of multi-agent coordination through high-order consensus protocols. While first-order consensus strategies are well-studied—with known robustness to uncertainties such as time delays, time-varying weights, and nonlinearities like saturations—the theoretical guarantees for high-order consensus are comparatively limited. We propose a compositional control framework tha

Post-mortem analysis of brains from Parkinson's disease (PD) patients strongly supports microglia activation and adaptive immunity as factors contributing to disease progression. Such responses may be triggered by alpha-synuclein (alpha-syn), which is known to be the main constituent of the aggregated proteins found in Lewy bodies in the brains of PD patients. To investigate this we used a recombi

Viral vector-mediated gene transfer has emerged as a powerful means to target transgene expression in the central nervous system. Here we characterized the efficacy of serotypes 1 and 5 recombinant adeno-associated virus (rAAV) vectors encoding green fluorescent protein (GFP) after stereotaxic delivery to the neonatal rat and minipig striatum. The efficiency of GFP expression and the phenotype of

Research aimed at developing new therapies for Parkinson's disease (PD) critically depend on valid animal models of the disease that allows for repeated testing of motor disabilities over extended time periods. We here present an extensive characterization of a wide range of motor symptoms in the 6-OHDA marmoset model of PD when tested over several months. The severity of motor deficits was quanti

Knowing the natural dynamics of pathogens in migratory birds is important, for example, to understand the factors that influence the transport of pathogens to and their transmission in new geographical areas, whereas the transmission of other pathogens might be restricted to a specific area. We studied haemosporidian blood parasites of the genera Plasmodium, Haemoproteus and Leucocytozoon in a mig

BACKGROUND: Dietary factors are thought to have an important role in gastric and esophageal carcinogenesis, but evidence from cohort studies for such a role is lacking. We examined the risks of gastric cancer and esophageal adenocarcinoma associated with meat consumption within the European Prospective Investigation Into Cancer and Nutrition (EPIC) cohort. METHODS: A total of 521,457 men and women

In this paper, a novel method for analysing a bird’s song is presented. The song of male great reed warblers is used for developing and testing the methods. A robust method for detecting syllables is proposed and a classification of those syllables as compared to reference syllables is done. The extraction of classification features are based on the use of singular vectors in different time-freque

Our world is changing and cities and regions are increasingly understood not only as places, but also as vital hubs in national and global networks, through which people, capital, goods and services flow to ensure the functioning of society, as we know it. People and capital are increasingly concentrated in these hubs, which aside of positive effects on efficiency also is associated with challenge

Using the findings of incident investigations to improve patient safety management is well-established and mandatory under Swedish law. This study seeks to identify the mechanisms behind successful implementation of the recommendations of incident investigations.

Design is an activity aimed at solving an unsolved problem or improving an existing solution. In the area of societal safety, there are many activities that could be classified as design activities. For example when different actors are implementing measures to mitigate certain risk scenarios or when they are considering actions that could improve their capability to respond to various crises. We

Abstract in UndeterminedThe increasing effectiveness and efficiency of modern society is not only beneficial, but also liable for new or increased vulnerabilities. The seemingly ever-increasing complexity of modern society is in other words bringing new challenges for safety, security and sustainability. At the heart of these challenges lay an incremental increase in dependencies between sectors,

The objective of this study was to compare subjects who sustained an ACL injury during soccer 16 years ago with a control group with regard to knee kinematics and kinetics of gait, step activity and cross over hop. Secondly, in the injured subjects, the purpose was to study the impact on kinematics and kinetics of characteristics such as operative status, meniscal resection, being symptomatic, hav

Choline acetyltransferase (ChAT) is the key-enzyme for acetylcholine (ACh) synthesis and constitutes a reliable marker for the integrity of cholinergic neurons. Cortical ChAT activity is decreased in the brain of patients suffering from Alzheimer's and Parkinson's diseases. The standard method used to measure the activity of ChAT enzyme relies on a very sensitive radiometric assay but can only be

Diagnosis by screening mammography is considered an independent positive prognostic factor, although the data are not fully in agreement. The aim of the study was to explore whether the mode of detection (screening-detected versus symptomatic) adds prognostic information to the St Gallen molecular subtypes of primary breast cancer, in terms of 10-year cumulative breast cancer mortality (BCM).

Abstract in UndeterminedOur world is changing and cities and regions are increasingly understood not only asplaces, but also as vital hubs in national and global networks, through which people,capital, goods and services flow to ensure the functioning of society, as we know it. Peopleand capital are increasingly concentrated in these hubs, which aside of positive effects onefficiency also is assoc