Sökresultat

HAMLET (Human alphalactalbumin made lethal to tumor cells), a complex between the partially unfolded alphalactalbumin and oleic acid, was discovered by serendipity when anti-adhesive properties of human milk were examined. HAMLET kills tumor cells but not healthy differentiated cells. Native alphalactalbumin (HLA) can be conveted to HAMLET by a two-step process including: 1) calcium ion removal in

The temperature distribution in concrete structures varies due to annual and daily climate variations. Solar radiation, air temperature, wind speed and long-wave radiation affect the temperature in the structure and may cause longitudinal and transversal movements. If these movements are restrained, stresses and strains can be induced which may contribute to cracking. To be able to predict the lon

This study investigated the urinary tract cytokine reponse to infection and the role of chemokines for neutrophil recruitment to the urinary tract. The results suggest that 1) IL-8 and TGFb are consitutively produced by uroepithelial cells in vivo, and that uroepithelial cells are stimulated to produce IL-1b and IL-6 by uropathogenic Escherichia coli. 2) MIP-2 (mouse IL-8 homologue) plays an impor

The question of the relation between the collective and the individual has had a long but patchy history within both philosophy and psychology. In this chapter we consider some arguments that could be adopted for the primacy of the we, and examine their conceptual and empirical implications. We argue that the we needs to be seen as a developing and dynamic identity, not as something that exists fu

A novel technology based on using particles of biological origin was recently developed for stabilising emulsions. This technology, that utilises Pickering emulsions, was further employed to encapsulate different types of active substances. Advance development and refinement of the technology has been performed in order to suit different encapsulation purposes in areas within personal care, food a

Associative learning in the cerebellum has previously focused on single movements. In eyeblink conditioning, for instance, a subject learns to blink at the right time in response to a conditional stimulus (CS), such as a tone that is repeatedly followed by an unconditional corneal stimulus (US). During conditioning, the CS and US are transmitted by mossy/parallel fibers and climbing fibers to cere

Working within the Langevin framework of nuclear shape dynamics, we study the dependence of the evolution on the degree of excitation. As the excitation energy of the fissioning system is increased, the pairing correlations and the shell effects diminish and the effective potential-energy surface becomes ever more liquid-drop like. This feature can be included in the treatment in a formally well-f

Popular Abstract in Swedish Vad är det för något i human mjölk som dödar cancer celler? Kan “fel” veckade proteiner vara nyttiga? Kan fett vara inblandat i protein veckning? Det är några av frågorna som tas upp i denna avhandling. Allt levande består av proteiner som i sin tur är uppbyggda av amino syror. Det finns 20 st. olika amino syror som på olika sätt kan länkas samman till proteinkedjor. DBy varying its secondary or tertiary structure a single protein can attain new biological functions. The amyloid forming proteins are the best known examples where a change in conformation leads to the formation of amyloid fibrils that accumulate in tissues and cause disease. a-lactalbumin in contrast, is an example of a protein that acquires a beneficial function when the conformation is altered

Group A streptococci, a common human pathogen, secrete streptokinase, which activates the host's blood clot-dissolving protein, plasminogen. Streptokinase is highly specific for human plasminogen, exhibiting little or no activity against other mammalian species, including mouse. Here, a transgene expressing human plasminogen markedly increased mortality in mice infected with streptococci, and this

Originally published in two volumes in 1748-9, John Cleland’s Memoirs of a Woman of Pleasure (or Fanny Hill) has long been an underground classic. Because of this underground status, and the prejudicial treatment of literary pornography, Memoirs has never been thoroughly investigated. Above all, insufficient attention has been given to the educational and moral aspects of Cleland’s novel. Cleland’

Fuel and load flexibility have been increasingly important features of industrial gas turbines in order to meet the demand for increased utilization of renewable fuels and to provide a way to balance the grid fluctuations due to the unsteady supply of wind and solar power. Experimental investigations were performed using a standard 3rd generation dry low emission (DLE) burner under atmospheric pre