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Ligand selectivity among the highly conserved galectins has been an ever-challenging objective. For galectin-8, a protein prevalent in both pathology and tissue distribution, we report phthalazinone-galactals that show excellent selectivity for the galectin-8N-terminal domain. A dissection of structure–activity relationships of the phthalazinone and an extensive molecular dynamics meta-analysis ac
BACKGROUND: The medial temporal lobe (MTL) is hypothesized to be relatively spared in early-onset Alzheimer's disease (EOAD). Yet, detailed examination of MTL subfield volumes and drivers of atrophy in amnestic EOAD is lacking.METHODS: BioFINDER-2 participants with memory impairment, abnormal amyloid-β status and tau-PET were included. Forty-one EOAD individuals aged ≤65 years and, as comparison,
BakgrundFör att tackla den rådande SARS-COV-2-pandemin har det ställts höga krav på en snabb utveckling och utvärdering av nya antivirala läkemedel. Bland några av de antivirala läkemedelskandidaterna finns imiquimod, en TLR7 agonist normalt administrerad för behandling av könsvårtor och basalcellscarcinom. Eftersom det har påvisats att imiquimod kan öka den antivirala responsen, är vår hypotes at
In the 1930s and 1940s, Ukraine experienced political violence on an unprecedented scale. Political violence by the Soviet government and the German occupation authorities resulted in the death of millions, through starvation, deportations, and massacres, and left wounds which still have not fully healed. Independently of the Soviets and Nazis, mass political violence was carried out also by the O
There has been an upsurge of interest in the principle of extended producer responsibility (EPR) among policy makers and scholars in non-OECD countries. The principle has been applied and its impacts studied rather extensively in various OECD countries. However, similar experiences are largely lacking in non-OECD countries. This paper presents some ongoing research and preliminary findings on the
Tidigare forskning har visat att patienter inom vuxenpsykiatrisk vård utsätts för kränkningar av vårdpersonal, där dehumanisering och stigmatisering av psykisk sjukdom ses som bidragande faktorer. Denna studie ämnade undersöka om det fanns skillnader mellan anmälningar till Inspektionen för vård och omsorg (IVO) rörande kränkande bemötande jämfört med anmälningar rörande andra bemötandebrister, utPrevious research has shown that patients in adult psychiatric care are subject to abuse by healthcare staff, where dehumanization and stigmatization of mental illness are seen as contributing factors. This study aimed to investigate whether there were differences between reports to the Health and Social Care Inspectorate (IVO) concerning abusive treatment compared to reports concerning other trea
This study (N=37 with high, medium, and low hyp-notizables) evaluated depth reports and EEG activity during both voluntary and hypnotically induced left-arm lifting with sLORETA functional neuroimaging. The hypnotic condition was associated with higher activity in fast EEG frequencies in anterior regions and slow EEG frequencies in central-parietal regions, all left-sided. The voluntary condition
In order to examine contemporary Russian cinema, this thesis has two points of departure: firstly the Petersburg myth, which is here defined as reversible or ambiguous since it includes both an eschatological and a cosmogonic aspect; and secondly, the Petersburg literary text as defined in works by Vladimir Toporov. During the twentieth century, the vitality and actuality of the Petersburg myth wa
The clinical spectrum of Trichomonas vaginalis infection varies from asymptomatic to mild, moderate or severe vaginitis. Nitric oxide and other reactive nitrogen radicals produced by immune effector cells are important cytotoxic and cytostatic mediators against several microorganisms including parasites. In the present study, inducible nitric oxide synthase (iNOS) and reactive nitrogen intermediat
Community-acquired infections, including respiratory tract infections (RTIs) and urinary tract infections (UTIs), represent a major burden for most healthcare systems, partially due to ineffective or inappropriate antibiotic treatment leading to clinical failure, which often requires alternative antibiotics for cure. Appropriate antimicrobial use not only maximises clinical success in the treatmen
