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Precision medicine utilizes genomic and other data to optimize and personalize treatment. Although more than 2,500 genetic tests are currently available, largely for extreme and/or rare phenotypes, the question remains whether this approach can be used for the treatment of common, complex conditions like obesity, inflammation, and insulin resistance, which underlie a host of metabolic diseases.

Prostate specific antigen (PSA), as a widely used clinical biomarker in prostate cancer diagnostics, exists in multiple molecular forms. However, all of these forms might not be recognized in a given sample by the standard immunoassays. Therefore, we have investigated PSA isoforms separated by size using mass spectrometric analyses. The objective of these developments was to identify and specify t

Mesenchymal stromal cells (MSC) are multipotent cells that can be isolated from a number of human tissues. In cancer, MSC have been implicated with tumor growth, invasion, metastasis, drug resistance and were even suggested as possible tumor-initiating cells in osteosarcoma (OS). However, MSC from OS and their possible tumor origin have not yet been thoroughly investigated. Therefore, primary OS m

Measurements of the prostate-specific antigen (PSA) levels in blood are widely used as diagnostic, predictive and prognostic marker of prostate disease. The selective detection of molecular forms of PSA can contribute clinically to meaningful enhancements of the conventional PSA-test. As it is plausible that an in-depth search for structural variants of PSA gene products may increase our ability t

Lymph node dissection (LND) in prostate cancer patients may increase complications. An association of LND with thromboembolic events has been suggested. We compared the incidence and investigated predictors of deep venous thrombosis (DVT) and pulmonary embolism (PE) among other complications in patients undergoing or not undergoing LND during open (ORP) and robot-assisted laparoscopic radical pros

Background Several trials evaluating the effect of prostate-specific antigen (PSA) testing on prostate-cancer mortality have shown conflicting results. We updated prostate-cancer mortality in the European Randomized Study of Screening for Prostate Cancer with 2 additional years of follow-up. Methods The study involved 182,160 men between the ages of 50 and 74 years at entry, with a predefined core

BACKGROUND. Serum response factor (SRF) is an important transcription factor in castrate-resistant prostate cancer (CRPC). Since CRPC is associated with androgen receptor (AR) hypersensitivity, we investigated the relationship between SRF and AR. MATERIALS AND METHODS. Transcriptional activity was assessed by luciferase assay. Cell proliferation was measured by MTT and flow cytometry. Protein expr

The dynamic HIV-1 epidemic has resulted in the emergence of several different subtypes and recombinant forms that may differ in biological properties. A recombinant form of CRF02_AG and sub-subtype A3 (A3/02) was recently described based on env sequencing and associated with faster disease progression rates compared with its parental strains. Here, we performed near full-length sequencing of the A

B-cell leukemia 3 (Bcl-3) is a member of the inhibitor of κB family, which regulates a wide range of biological processes by functioning as a transcriptional activator or as a repressor of target genes. As high levels of Bcl-3 expression and activation have been detected in different types of human cancer, Bcl-3 has been labeled a proto-oncogene. Our study uncovered a markedly upregulated Bcl-3 ex

Once prostate cancer becomes castration resistant, cancer cells may rapidly gain the ability to invade and to metastasize to lymph nodes and distant organs. The progression through hormone-dependent to hormone-independent/castration-resistant and metastatic PCa is poorly understood. In this review paper, we provide an overview on the cellular and molecular mechanisms underlying the process of tumo

Access to a quiet side in one's dwelling is thought to compensate for higher noise levels at the most exposed façade. It has also been indicated that noise from combined traffic sources causes more noise annoyance than equal average levels from either road traffic or railway noise separately.

OBJECTIVE: The brain derived neurotrophic factor (BDNF) locus has been implicated in psychiatric and substance related disorders. Recent genome-wide association studies (GWAS) have shown strong associations between single nucleotide polymorphisms in BDNF, smoking behaviour and high body mass index (BMI). Our aim was to test whether genetic BDNF variation alters the risk of smoking related morbidit

BACKGROUND & AIMS: Some autoimmune diseases are associated with increased risk of liver cancer. However, there has been no comprehensive evaluation of autoimmune diseases among patients who develop different subtypes of hepatobiliary cancer. We examined the association between autoimmune diseases and cancers of the liver and biliary tract in the Swedish population. METHODS: We analyzed data fr

Working Papers in Scandinavian Syntax 85 (2010) 1-36 Scandinavian Object Shift as the Cause of Downstep* Mayumi Hosono Abstract I discuss Object Shift OS (Holmberg 1986) from the point of view of the intonational properties of Swedish (Bruce 1977, 1999, 2005, 2007). On the basis of experimental data, I show that F0 of the sentential elements that follow a focus-accented main verb is lower than F0

https://projekt.ht.lu.se/fileadmin/_migrated/content_uploads/WPSS_85_Mayumi.pdf - 2026-05-04

https://www.folklivsarkivet.lu.se/fileadmin/user_upload/folklivsarkivet/upload/levnadsminne/M_6710_s_1-34.pdf - 2026-05-07

LTHs kursutvärderingar - Nyheter www ceq.lth.se     Anpassa utseende Översikt English Kursutvärderingar Om LTHs kursutvärderingar Arbetsgång/Tidsplan Nyheter (+ arkiv) Info till externa representanter Kontaktinformation Mina CEQ:er/MyCEQ Dokument Kurser som utvärderas Arkiv / Färdiga kursutvärderingar Specialrapporter Examensarbeten (utvärdering) Praktikkurser (utvärdering) Institutions- sammanstä

https://www.ceq.lth.se/info/nyheter/ - 2026-05-07

Tack för alla intresseanmälningar vi fått in! Formuläret är nu stängt och vi är i processen att gå igenom alla anmälningar, vi återkommer till var och en så snart vi kan. På den här sidan hittar du som arrangör tips på hur du kan planera ett framgångsrikt, hållbart event, samt vad vi i planeringsgruppen kan bidra med för stöd. Checklista för att arrangera ett event Några saker att tänka på när du

https://www.hallbarhet.lu.se/hallbarhetsveckan/arrangorer - 2026-05-07

På denna sida kan du läsa mer om rutinen för löpande semesterkostnad. Syftet med modellenSedan 2006 har Lunds universitet en rutin där kostnaden för semesterdagar löpande bokförs som en kostnad i den verksamhet där den anställde är lönekonterad och tjänar in sina semesterdagar. För Lunds universitet som helhet periodiseras kostnaden och läggs som en skuld på central nivå. Vid uttag av semesterdaga

https://www.ekonomiwebben.lu.se/mitt-arbete/overgripande-om-ekonomi-och-redovisning/ekonomimodellen/principer-och-rutiner/lopande-semesterkostnad - 2026-05-07