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Intervention strategies in early childhood to prevent celiac disease—a mini-review
A higher intake of gluten during childhood is associated with increased risk of celiac disease, and the incidence of celiac disease peaks shortly after the time point when associations with higher gluten intake during the second and third year of life occur. Additional environmental factors are most likely necessary for celiac disease to develop. It is hypothesized that gastrointestinal infections
Sex differences in disease progression in Alzheimer patients with different concomitant medications.
Objectives: To examine potential sex differences in cognitive and functional progression rates in Alzheimer’s disease (AD) between patients with different concomitant medications. Methods: The Swedish Alzheimer Treatment Study is a prospective, observational, multicentre study in clinical practice undertaken at the initiation of cholinesterase inhibitor therapy in 1,021 patients diagnosed with mil
Pre-hospital conditions affecting the hospitalization risk in older adults at the Emergency Department
BACKGROUND: The Emergency Department (ED) is a common route to hospitalization for critically ill and older adults. Older patients are admitted to hospital at a higher rate and have longer length of stay (LOS) when hospitalized. To be able to confront an increasing aging population, meet their medical needs and influence rising costs of health care, there is a need to focus on the older population
In Situ Synchrotron-Based Studies of IrO2(110)-TiO2(110) under Harsh Acidic Water Splitting Conditions : Anodic Stability and Radiation Damages
In situ stability studies of an IrO2(110)-TiO2(110) model electrode are carried out under acidic water electrolysis conditions, employing synchrotron-based techniques including surface X-ray diffraction (SXRD) and X-ray reflectometry (XRR) with a photon energy of 21.5 keV. These experiments are complemented by ex situ scanning electron microscopy (SEM), scanning tunneling microscopy (STM), and X-r
Successful invasions to freshwater systems double with climate warming
Although invasive species are recognized as a major threat to freshwaters, little is known about how future climate warming will affect the success of invaders. Ecosystems are also often simultaneously impacted by multiple, potentially interacting, invading species and the management of species invasions can be incredibly difficult. Sensitive methods such as environmental DNA (eDNA) metabarcoding,
The National Prevalence of Clinically Diagnosed Psoriatic Arthritis in Sweden in 2017
Objective. Psoriatic arthritis (PsA) prevalence estimates vary across studies; studies based on national data are few. We aimed to estimate the prevalence of clinically diagnosed PsA in Sweden in 2017, overall and stratified by sex, age, education, and geography, and to quantify disease-modifying antirheumatic drug (DMARD) use among those in contact with specialized rheumatology care between 2015
The etiology of Parkinson's disease. Genetic and non-genetic risk factors for a multifactorial disease
Optimising conditions and environments for digital participation in later life: a macro-meso-micro framework of partnership-building
The ongoing digitalisation of societies, exacerbated by the COVID-19 pandemic, has led to increased efforts to ensure the digital inclusion of older adults. Digital inclusion strategies throughout the COVID-19 pandemic predominantly focused on increasing access and basic digital literacy of Information and Communication Technologies (ICTs) for all members of society. Older adults, who are more lik
Dietary patterns during early childhood confer different risk of celiac disease autoimmunity and celiac disease in children at genetic risk: TEDDY study
A 2D Bismuth-Induced Honeycomb Surface Structure on GaAs(111)
Two-dimensional (2D) topological insulators have fascinating physical properties which are promising for applications within spintronics. In order to realize spintronic devices working at room temperature, materials with a large nontrivial gap are needed. Bismuthene, a 2D layer of Bi atoms in a honeycomb structure, has recently attracted strong attention because of its record-large nontrivial gap,
Gluten-free diet adherence in children with screening-detected celiac disease using a prospective birth cohort study
Background Celiac disease has an increasing incidence worldwide and is treated with lifelong adherence to a gluten-free diet. We aimed to describe gluten-free diet adherence rates in children with screening-identified celiac disease, determine adherence-related factors, and compare adherence to food records in a multinational prospective birth cohort study. Methods Children in The Environmental De
Pediatric coeliac disease
A new model of paired clinical teaching of international and Danish medical students
INTRODUCTION: Since 2006, one hospital has offered two clinical courses in obstetrics/gynaecology and paediatrics to international (I) students. However, as I-student enrolment increased, the hospital faced cut-backs. As from 2010, I-team course evaluations therefore dropped to unacceptable levels and more I- than Danish (DK) students failed exams. Therefore, in 2012 we started a three-year intern
An Overview of Systematic Reviews and Meta-Analyses on the Effect of Medication Interventions Targeting Polypharmacy for Frail Older Adults
Frailty refers to the lack of resilience and a reduction in a person’s ability to recover following a health problem, and it is increasingly becoming a challenging aspect of ageing populations.Many older adults are exposed to polypharmacy; i.e., they continue to be on medications without timely re-evaluation. Medication reviews have proven successful in managing polypharmacy in the general populat
Analysis of time-of-flight small-angle neutron scattering data on mesoscopic crystals such as magnetic vortex lattices
Bragg diffracted intensities and q values for crystalline structures with long repeat distances may be obtained by small-angle neutron scattering (SANS) investigations. An account is given of the methods, advantages and disadvantages of obtaining such data by the multichromatic time-of-flight method, compared with the more traditional quasi-monochromatic SANS method. This is illustrated with data
Parental alcohol use disorder and offspring marital outcomes
Aims: We tested whether parental alcohol use disorder (AUD) predicted adult offspring's likelihood of marriage and marriage to an AUD-affected spouse; whether effects differed as a function of the sex or number of affected parents; and whether they were robust to confounders. Design: Sex-stratified Cox and logistic regression models. Setting: Sweden. Participants: A total of 1 171 070 individuals
Second primary cancers in non-Hodgkin lymphoma : Bidirectional analyses suggesting role for immune dysfunction
Second primary cancers (SPCs) account for an increasing proportion of all cancer diagnoses. It is unlikely that prior therapy is solely responsible for SPC risk. To investigate risk of SPC after diagnosis of non-Hodgkin lymphoma (NHL) and 10 of its subtypes we conducted a novel bidirectional analysis, SPCs after NHL and NHL as SPC. Using the Swedish Family-Cancer Database, we identified 19,833 ind
Impact of family history of cancer on risk and mortality of second cancers in patients with prostate cancer
Background: Survival rates are increasing in patients with prostate cancer, and second primary cancers (SPCs) are becoming more common in these patients. However, the etiology and clinical consequences of SPCs are not well-known. We define the impact of family history on SPC and causes of mortality in these patients. Patients and methods: A nation-wide cohort study based on the Swedish Family-Canc
