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Balance and gait disorders in de novo Parkinson’s disease : support for early rehabilitation

BACKGROUND: Postural instability is considered a late complication of Parkinson’sdisease (PD). However, growing evidence shows that balance and gait problems mayoccur early in the disease.OBJECTIVE: To describe balance, gait, and falls/near falls in persons with newlydiagnosed, untreated PD (“de novo”), and to compare this with persons with mildmoderatePD (Later PD). In addition, we evaluated diffBackgroundPostural instability is considered a late complication of Parkinson’s disease (PD). However, growing evidence shows that balance and gait problems may occur early in the disease.ObjectiveTo describe balance, gait, and falls/near falls in persons with newly diagnosed, untreated PD (“de novo”), and to compare this with persons with mild-moderate PD (Later PD). In addition, we evaluated dif

Estimating historical PFAS exposures in Ronneby, Sweden using biobanked dried blood spots from newborns

BACKGROUND: In 2013, it was discovered that a subset of the population in Ronneby, Sweden was exposed to high levels of perfluorinated compounds (PFAS) from drinking water that had been provided by the local Brantafors waterworks and was contaminated by fire-fighting foam from a nearby airport. The start and time-course of population exposures are not known.OBJECTIVE: To investigate the start of P

Xputer : bridging data gaps with NMF, XGBoost, and a streamlined GUI experience

The rapid proliferation of data across diverse fields has accentuated the importance of accurate imputation for missing values. This task is crucial for ensuring data integrity and deriving meaningful insights. In response to this challenge, we present Xputer, a novel imputation tool that adeptly integrates Non-negative Matrix Factorization (NMF) with the predictive strengths of XGBoost. One of Xp

Alterations of the chemical profile of cholesterol in cancer tissue as traced with ToF-SIMS

Cancer has become one of the leading causes of death, with approximately ten million people worldwide dying from cancer each year. In most cases, cancer spreads to remote organs and develops a resistance to therapy. To reduce the deadly impact of cancer, novel targets for markers for early detection are necessary. Given the notable influence of rapid chemical turnover on isotope effects, the heigh

Chemical profiling of surviving cancer cells using ToF-SIMS and MCR analysis discriminates cell components

Cancer cells survive treatment through mechanisms that remain unclear. This study investigates the chemical changes that occur in cancer cells after treatment, focusing on lipid metabolism as a potential marker for survival and resistance. Using Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS) and advanced multivariate statistical analysis, we compared the chemical profiles of untreated a

Accelerating target deconvolution for therapeutic antibody candidates using highly parallelized genome editing

Therapeutic antibodies are transforming the treatment of cancer and autoimmune diseases. Today, a key challenge is finding antibodies against new targets. Phenotypic discovery promises to achieve this by enabling discovery of antibodies with therapeutic potential without specifying the molecular target a priori. Yet, deconvoluting the targets of phenotypically discovered antibodies remains a bottl

Stochastic models of Mendelian and reverse transcriptional inheritance in state-structured cancer populations

Recent evidence suggests that a polyaneuploid cancer cell (PACC) state may play a key role in the adaptation of cancer cells to stressful environments and in promoting therapeutic resistance. The PACC state allows cancer cells to pause cell division and to avoid DNA damage and programmed cell death. Transition to the PACC state may also lead to an increase in the cancer cell’s ability to generate

A life history model of the ecological and evolutionary dynamics of polyaneuploid cancer cells

Therapeutic resistance is one of the main reasons for treatment failure in cancer patients. The polyaneuploid cancer cell (PACC) state has been shown to promote resistance by providing a refuge for cancer cells from the effects of therapy and by helping them adapt to a variety of environmental stressors. This state is the result of aneuploid cancer cells undergoing whole genome doubling and skippi

Origin and evolution of animal multicellularity in the light of phylogenomics and cancer genetics

The rise of animals represents a major but enigmatic event in the evolutionary history of life. In recent years, numerous studies have aimed at understanding the genetic basis of this transition. However, genome comparisons of diverse animal and protist lineages suggest that the appearance of gene families that were previously considered animal specific indeed preceded animals. Animals’ unicellula

Survival patterns of neonates born to adolescent mothers and the effect of pregnancy intentions and marital status on newborn survival in Kenya, Uganda, and Tanzania, 2014-2016

Background: Adolescent pregnancy and associated neonatal mortality are major global health challenges. In low-income settings where 90% of the 21 million global adolescent pregnancies occur, half are unintended and a fifth experience unsafe abortion. In Kenya, Uganda, and Tanzania, the survival patterns of neonates born to adolescents are unclear.Objectives: To assess survival patterns among neona

Blood lead levels and risk of atherosclerosis in the carotid artery : Results from a swedish cohort

BACKGROUND: Lead exposure has been associated with increased incidence of adverse clinical cardiovascular outcomes. Atherosclerosis has been suggested as one of the underlying mechanisms, and findings from experimental studies support this, but human data are scarce. OBJECTIVES: Our objective was to determine the association between environmental lead exposure based on blood lead (B-Pb) concentrat

Eva Saether

Professor emerita Contact details Email: eva [dot] saether [at] mhm [dot] lu [dot] seOrganisation Teachers (Malmö Academy of Music) WebpageEva Saethers profile in Lund University research portalI am Professor emerita in Music Education with Educational Sciences as profile. With a musical point of departure in Swedish traditional fiddle music, I have developed a research profile that focuses on int

https://www.mhm.lu.se/en/eva-saether - 2025-12-10

Marie-helene westholm

Microsoft Word - Final Thesis Draft 20-05-08.doc 1 “Offshore Wind Power and the Challenges related to Public Participation and Local Acceptance: Comparative Case study in France and Denmark” By Marie-Hélène Westholm Collinsgade 5, 1th 2100 Copenhagen, Denmark E-mail: MHWestholm@gmail.com Tel: +4535354585 Supervisors: Åsa Waldo Department of Sociology, Lund University Phone: + 46 (0)46 222 95 65 E-

https://www.lumes.lu.se/sites/lumes.lu.se/files/marie-helene_westholm.pdf - 2025-12-10

Prop 201718 218

Behandling av personuppgifter på utbildningsområdet 1 Regeringens proposition 2017/18:218 Behandling av personuppgifter på utbildningsområdet Prop. 2017/18:218 Regeringen överlämnar denna proposition till riksdagen. Stockholm den 5 april 2018 Stefan Löfven Gustav Fridolin (Utbildningsdepartementet) Propositionens huvudsakliga innehåll Propositionen innehåller förslag till lagändringar på utbildnin

https://www.medarbetarwebben.lu.se/sites/medarbetarwebben.lu.se/files/prop_201718_218.pdf - 2025-12-10

Meritpoanglista omrade 4

Meritpoänglista – område 4.indd Områdesbehörighet 4 Du kan få extra poäng att lägga till ditt jämförelsetal från gymnasieskolan. De poängen får du genom att läsa vissa kurser till en viss nivå. Du kan få maximalt 2,5 meritpoäng att lägga till ditt jämförelsetal genom att få lägst betyget godkänt i olika kombinationer av kurserna nedan. Vem kan få meritpoäng? För detaljerad information se https://w

https://www.isk.lu.se/sites/isk.lu.se/files/meritpoanglista_omrade_4.pdf - 2025-12-10

Studenthandbok 2019 svenska

1 Studenthandbok 2019/20 INSTITUTIONEN FÖR STRATEGISK KOMMUNIKATION 2 Välkommen! Strategisk kommunikation är ett flervetenskap- ligt ämne som hjälper oss att förstå, analysera och granska verksamhetskommunikation inom företag, offentliga organisationer och myndigheter utifrån ett holistiskt perspektiv. Kommunikation är grund- läggande i alla typer av arbeten. Förmågan att kom- municera väl blir al

https://www.isk.lu.se/sites/isk.lu.se/files/studenthandbok_2019_svenska.pdf - 2025-12-10

Gå Mjukt På Jorden / Work-In-Progress Concert

31 januari 2025 12:00 | Konsert Welcome to a work-in-progress Friday concert with visual artist Elin Maria Johansson, poet Ylva Gislén and the band Cecilia Nordlund & Fullmånen Från Helvetet, presenting an audiovisual concert entitled “Gå Mjukt På Jorden“, which will go on tour this spring. In this project, the artists explore how visuals, music and poetry can be combined to create an immersive ex

https://www.medarbetarwebben.lu.se/evenemang/ga-mjukt-pa-jorden-work-progress-concert - 2025-12-10

Larosaten Syd Policy Update 2025-06-11 0

11-06-2025 Policy Update 10 For Lund Universities Profile Area Nature Based Future Solutions Public consultation on “Simplification of the implementation of CAP Strategic Plans” ....................... 1 Public consultation on “Nature Restoration Law - Method for monitoring pollinator diversity and pollinator populations” (UPDATED) ..................................................................

https://www.cec.lu.se/sites/cec.lu.se/files/2025-06/Larosaten%20Syd%20Policy%20Update%202025-06-11_0.pdf - 2025-12-10

T1D prevention

Anette-G. Ziegler,1,2 Ezio Bonifacio,3,4,5 Alvin C. Powers,6,7,8 John A. Todd,9 Leonard C. Harrison,10 and Mark A. Atkinson11 Type 1 Diabetes Prevention: A Goal Dependent on Accepting a Diagnosis of an Asymptomatic Disease Diabetes 2016;65:3233–3239 | DOI: 10.2337/db16-0687 Type 1 diabetes, a disease defined by absolute insulin defi- ciency, is considered a chronic autoimmune disorder re- sulting

https://www.gppad.lu.se/sites/gppad.lu.se/files/2025-05/T1D_prevention.pdf - 2025-12-10