CFD modeling and comparison of bioreactor performance across scales at Alvotech
At Alvotech, bioreactors are used for the production of biosimilars. During the production scale-up process, issues can arise at larger scale that are difficult to predict based on physical experiments. Using CFD, two 3D bioreactor models of different scales have been created, namely the 15L HyPerformaTM Glass Bioreactor and 250L HyPerformaTM Single-Use Bioreactor, both manufactured by Thermo FishDuring bioreactor scale-up, unexpected failures become more prevalent due to the increase in volume. A comparison of mixing performance was thus made using computational modeling for two bioreactors at different scales. At the biopharmaceutical company Alvotech, bioreactors are used at different scales for producing biological medicines known as biosimilars. Bioreactors are vessels containing a m