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Aims: According to Braak's hypothesis, it is plausible that Parkinson's disease (PD) originates in the enteric nervous system (ENS) and spreads to the brain through the vagus nerve. In this work, we studied whether inflammatory bowel diseases (IBDs) in humans can progress with the emergence of pathogenic α-synuclein (α-syn) in the gastrointestinal tract and midbrain dopaminergic neurons. Methods:

Research into entrepreneurship education has explored content, audience and pedagogy but much is still to be studied when it comes to the spatial dimensions of learning–that is, where entrepreneurship is taught, how this matters for pedagogies used, and the implications for learning. We seek to strengthen a theoretical foundation for understanding learning spaces and the spatial dimensions in entr

In our Introduction to this Special Issue on Organizational and Institutional Entrepreneuring, we draw attention to the importance of recognizing how processes and practices of entrepreneuring take place in the context of an already organized world. We particularly draw attention to how such entrepreneuring processes, as imaginative-poetic extensions beyond the present, can occur in a variety of s

In an epilogue, Daniel Hjorth and Chris Steyaert aim to further multiply the new movements in academic entrepreneurship that this volume identifies. Therefore, they introduce a conceptual quartet that makes and keeps movement going: provocation, mobilization, affirmation, and experimentation. Their conceptual contribution, which has to be seen as an attempt to stir and disturb, relates these four

The article is based on a theoretical exploration and empirical analysis of formalized public initiated instruments—eight network entrepreneurs—intended to promote, intermediate and support innovation and entrepreneurship in firms and firm networks located in three different business areas in Mid-Norway: food value chain, experience industries, and renewable energy and environmental technology. Th

The main objectives of bioprocesses are to reliably deliver drugs in a relatively short time frame with high quality within a tight regulatory framework. Bioprocesses are highly complex, the level of automation is moderate, and there is constant pressure to improve efficiency and costs. In addition, climate change and resource scarcity mandate a reduction in the environmental footprint of bioproce

Findings on the correlation between the use of antihypertensive medication and the risk of breast cancer (BC) have been inconsistent. We performed a two-sample Mendelian randomization (MR) using instrumental variables to proxy changes in gene expressions of antihypertensive medication targets to interrogate this. Genetic instruments for expression of antihypertensive drug target genes were identif

Research on creative organizations often highlights a concern that economic influences on creative work might crowd out aesthetic influences. How this concern can be managed, however, is not well understood. Using a case study of an economic/aesthetic conflict within a design firm, we develop theory to describe how the economic and aesthetic can be constructively combined. We propose the concept o

Our title is a play on Nietzsche’s Schopenhauer as Educator first published in his essay collection Unfashionable Observations. Within the setting of teaching and studying management practice our chapter is also unfashionable. It argues for a primacy of honesty in feeling in a practice that can encourage the rational selection and manipulation of viewpoints. It argues for cheerful and generous exp

In this article we focus on the study of history through the use of narratives, within the context of the prevalent form of organization worldwide: the family business. Specifically we consider the dilemma of the impossible gift of succession using Nietzsche’s discussion of the burden of history and paralleling the story of a family business succession with that of Shakespeare’s King Lear. This wa