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Although Rac and its activator Tiam1 are known to stimulate cell-cell adhesion, the mechanisms regulating their activity in cell-cell junction formation are poorly understood. Here, we identify beta 2-syntrophin as a Tiam1 interactor required for optimal cell-cell adhesion. We show that during tight-junction (TJ) assembly beta 2-syntrophin promotes Tiam1-Rac activity, in contrast to the function o

The present study describes the development and testing of a tool for dolphin research. This tool was able to visualize the dolphin echolocation signals as well as function as an acoustically operated “touch screen”. The system consisted of a matrix of hydrophones attached to a semi-transparent screen, which was lowered in front of an underwater acrylic panel in a dolphin pool. When a dolphin aime

Purpose – The purpose of this paper is to investigate how food manufacturers in Sweden define and view innovations, how they view their role and those of other actors and the interaction/collaboration regarding innovations in the food supply/value chain. Design/methodology/approach – After an exploratory pre-study with 12 participants, a full study of Swedish manufacturers comprised of represent

The complement (C') cascade is an important part of the innate immunity. It acts through three major pathways: classical (CP), alternative (AP) and mannose-binding-lectin (MP). C' reduction is a key feature in systemic lupus erythematosus (SLE), for its pathogenesis and for disease relapse. The aims of our study are to correlate C' variations with disease activity and verify the presence of C' def

The use of a transport system for out-oftreatment room set-up in external beam radiotherapy has been verified. We have looked into the vibrations which a patient is subject to during movement of the trolley as well as the accuracy achieved when using a reclining table for patient set-up and immobilization. The accuracy that can be achieved by the reclining approach is compared to conventional meth

In two papers, Pekala et al. (2010a, 2010b) reviewed and empirically assessed the relationships among response expectancies, hypnotic suggestibility, spontaneous alterations in consciousness following a hypnotic induction, and hypnotic depth. We appreciate their attempt to integrate diverse facets of hypnotic responding and reconcile seemingly competing accounts of hypnosis. In addition, we applau

Results are presented of a search for particles decaying into final states with significant missing transverse momentum and exactly two identical flavour leptons (e, mu) of opposite charge in root s = 7 TeV collisions at the Large Hadron Collider. This channel is particularly sensitive to supersymmetric particle cascade decays producing flavour correlated lepton pairs. Flavour uncorrelated backgro

It is the aim of this thesis to explore whether salaryman masculinity has lost its status as a hegemonic form of masculinity to otaku masculinity or herbivore masculinity. The thesis makes use of the theoretical framework of hegemonic masculinity as first used by R.W. Connell. In order to assess changes in masculinity, 16 semi-structured in-depth interviews have been conducted with students, both

Follow-up methods must be easy for young people to handle. We examine Interactive Voice Response (IVR) as a method for collecting self-reported data. Sixty inpatients were recruited from a child and adolescent psychiatric emergency unit in Malmö, Sweden and called every second (N = 30) or every fourth (N = 30) day from discharge until first visit in outpatient care. A pre-recorded voice asked them

Vi granskar den uppmärksammade kritik som Lars E O Svensson riktat mot Riksbankens penningpolitik. Vi har en rad invändningar. Svensson har ett för snävt synsätt när han bedömer om Riksbanken har uppfyllt sitt inflationsmål. Hans ekonometriska resultat, vilka utmynnar i slutsatsen att Riksbankens politik gett 38 000 fler arbetslösa per år under 1997−2011, är inte robusta. De vilar på en alltför en

Popular AbstractDenna rättssociologiska avhandling studerar "law in progress" genom att undersöka de normbildningsprocesser som framkommer i en interaktion mellan aktörer över tid. Avhandlingen har en empirisk utgångspunkt och illustrerar dessa processer utifrån ett empiriskt exempel, ett Europeiskt "Earth Observation" (EO) initiativ: Global Monitoring for Environment and Security (GMES). AvhandliThis PhD-thesis in Sociology of Law studies ”Law in Progress” by investigating norm-generating processes, which emerge through an interaction between actors over time. The thesis has an empirical approach, thus illustrates these processes through an empirical example, a European “Earth Observation” (EO) initiative: Global Monitoring for Environment and Security (GMES). The main research questions

Atypical hemolytic uremic syndrome (aHUS) is characterized by the triad of microangiopathic hemolytic anemia, thrombocytopenia, and renal impairment. Neonatal cases are extremely uncommon. Plasma therapy is the first choice therapy in patients with aHUS based on the belief of an underlying complement dysregulation. Alternatively, eculizumab, which targets complement 5, is used to block complement

We present a theory for a mesoscopic turnstile that produces spatially separated streams of electrons and holes along edge states in the quantum Hall regime. For a broad range of frequencies in the nonadiabatic regime the turnstile operation is found to be ideal, producing one electron and one hole per cycle. The accuracy of the turnstile operation is characterized by the fluctuations of the trans

To further understanding of the genetic basis of type 2 diabetes (T2D) susceptibility, we aggregated published meta-analyses of genome-wide association studies (GWAS), including 26,488 cases and 83,964 controls of European, east Asian, south Asian and Mexican and Mexican American ancestry. We observed a significant excess in the directional consistency of T2D risk alleles across ancestry groups, e

Background: Cancer in the sinonasal tract is rare, but persons who have been occupationally exposed to wood dust have a substantially increased risk. It has been estimated that approximately 3.6 million workers are exposed to inhalable wood dust in EU. In previous small studies of this cancer, ras mutations were suggested to be related to wood dust exposure, but these studies were too limited to d

In cerebral palsy (CP) there is an increased risk of scoliosis. It is important to identify a progressive scoliosis early-on because the results of surgery depend on the magnitude of the curve. The Swedish follow-up program for cerebral palsy (CPUP) includes clinical examinations of the spine. The reliability and validity of the assessment method have not been studied. In this study we evaluate th

Internal dynamics of dansylated poly(propyleneamine) dendrimers (POPAM, G1-G4) in solution and excitation energy transfer from dansyls to eosin in POPAM-eosin complexes have been studied by time-resolved fluorescence spectroscopy and molecular dynamics (MD) simulations. Combining the results from fluorescence anisotropy and the MD simulation studies suggests three time domains for the internal dyn