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Activation of dopamine D1 receptors (D1Rs) has been shown to induce epileptiform activity. We studied the molecular changes occurring in the hippocampus in response to the administration of the D1-type receptor agonist, SKF 81297. SKF 81297 at 2.5 and 5.0 mg/kg induced behavioural seizures. Electrophysiological recordings in the dentate gyrus revealed the presence of epileptiform discharges peakin

Aquaporin-mediated water transport across cellular membranes is an ancient, ubiquitous mechanism within cell biology. This family of integral membrane proteins includes both water selective pores (aquaporins) and transport facilitators of other small molecules such as glycerol and urea (aquaglyceroporins). Eukaryotic aquaporins are frequently regulated post-translationally by gating, whereby the r

The ability to form long-term memories exists very early during ontogeny; however, the properties of early memory processes, brain structures involved and underlying cellular mechanisms are poorly defined. Here, we examine the role of extracellular signal-regulated kinase (ERK), a member of the mitogen-activated protein kinase/ERK signaling cascade, which is crucial for adult memory, in the consol

In the dopamine-depleted striatum, extracellular signal-regulated kinase (ERK) signaling is implicated in the development of l-DOPA-induced dyskinesia. To gain insights on its role in this disorder, we examined the effects of l-DOPA on the state of phosphorylation of ERK and downstream target proteins in striatopallidal and striatonigral medium spiny neurons (MSNs). For this purpose, we employed m

The staphylococcal enterotoxin H (SEH; 217 aa, 25 kD) belongs to a family of superantigens that cause a massive immune response upon simultaneous binding to the T cell receptor (TCR) and the major histocompatibility complex class II. The SEH-TCR interaction is weak and amenable to studies using NMR methodology. Essentially, 2 mg of U{2H, 13C,15N}-labeled SEH was used for the complete sequential ba

Aquaporins are transmembrane proteins that facilitate the flow of water through cellular membranes. An unusual characteristic of yeast aquaporins is that they frequently contain an extended N terminus of unknown function. Here we present the X-ray structure of the yeast aquaporin Aqy1 from Pichia pastoris at 1.15 Å resolution. Our crystal structure reveals that the water channel is closed by the N

The existing research often overlooks the fact that accommodation sharing is not a homogeneous sector but comprises rental, reciprocal and free platforms. This paper aims to compare sustainability narratives held by operators and users of the three platform types with the narratives identified in the literature. First, drawing on framing theory, environmental, economic and social framings of accom

Leadership is important. Management is important. However, leadership and management is not the same thing, in fact they are fundamentally different. In a cross disciplinary master programme named Technology Management at Lund University, Sweden, the students are given opportunities to study and learn management, however, what makes the program unique is its profound focus on leadership. The Techn

Today, innovation and entrepreneurship are key words for many universities, as it constitutes an important part of most universities’ public and scientific outreach task. Universities are striving to increase the number of innovations and entrepreneurs generated by the university. Teaching and learning entrepreneurship is therefore of importance and schools, colleges and universities can play an i

The anations of Pt(H2O)42+ and PtX(H2O)3+ (to trans-PtX(H2O)2) by X− = Cl−, Br−, I− and SCN− and the anation of trans-PtX2(H2O)2) by X− = Cl−, Br− and I− have been studied at 25 °C and 1.00 M perchlorate medium using both stopped-flow and conventional spectrophotometry. For large excess of X−, PtX42− is formed according to the mechanism in Figure 1. The results indicate an entering ligand order ofThe anations of Pt(H2O)42+ and PtX(H2O)3+ (to trans-PtX(H2O)2) by X− = Cl−, Br−, I− and SCN− and the anation of trans-PtX2(H2O)2) by X− = Cl−, Br− and I− have been studied at 25 °C and 1.00 M perchlorate medium using both stopped-flow and conventional spectrophotometry. For large excess of X−, PtX42− is formed according to the mechanism in Figure 1. The results indicate an entering ligand order of

The integration of scheduling and control has been discussed in the past. While constructing an integrated plant model that may still seem out of reach, scheduling and control systems are increasingly more intertwined. We argue that they are in fact already integrated and give the example of two key performance indicators (KPIs) that are defined in the recent international standard ISO 22400. The

Semiconducting indium sulfide (In2S3) has recently attracted considerable attention as a buffer material in the field of thin film photovoltaics. Compared with this growing interest, however, detailed characterizations of the crystal structure of this material are rather scarce and controversial. In order to close this gap, we have carried out a reinvestigation of the crystal structure of this mat

Deoxyribonucleic acid or DNA is one of the most fundamental molecules of life as it encodes the basic structure of every living entity, including us. Not only is DNA responsible for precisely describing every single aspect that makes us, it also directly affects the world around us. Indeed, unlocking the genetic code embedded in DNA already enabled us to create new diagnostics that allow us to det

Att få uppleva rörelse är en stark drivkraft för att främja lärande och öka barns delaktighet i vardagen. Eldrivna hjälpmedel används för att ge barn möjlighet till självständig förflyttning men också för att förbättra deras psykosociala utveckling. Metoden Köra för att Lära utvecklades för barn och vuxna med stora kognitiva svårigheter och den är baserad på aktivitet och samspel under övning i el

Den här kunskapsöversikten fokuserar en viktig del av vad jag i en tidigare rapport (Larsson, 2016) kallar en tilltagande informationsasymmetri, nämligen profilering av konsumenter för kommersiella syften. I kunskapsöversikten tecknas kunskapsläget kring digital konsumentprofilering, framförallt utifrån en problematisering av detta rörliga och snabbt framväxande fält i relation till konsumentens i

Presents a research and re-evaluation of studies focusing on the Stone Age in Scania. This book addresses many issues concerned with the methodology of contract archaeology and how it differs from university-based research. Covering a long period from the first settlers in Scania, it contains lots of photographs, drawings and maps.