Structure-activity studies of novel colchicine analogs.
Colchicine, a well-known alkaloid isolated from Colchicum autumnale, interferes with microtubule growth and, therefore affects mitosis and other microtubule dependent functions. We have been interested in the structural requirements of colchicine for tubulin recognition. In particular our interests have been focused on the active colchicine conformation with respect to the pivot bond joining the A
