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BACKGROUND: Metformin use has been associated with improved survival in patients with different types of cancer, but research regarding the effect of metformin on cutaneous melanoma (CM) survival is sparse and inconclusive.OBJECTIVES: To investigate the association between metformin use and survival among patients with CM and diabetes.METHODS: All adult patients with a primary invasive CM between
1. Challenging calibration of complex models can be approached by using prior knowledge on the parameters. However, the natural choice of Bayesian inference can be computationally heavy when relying on Markov Chain Monte Carlo (MCMC) sampling. When the likelihood of the data is intractable, alternative Bayesian methods have been proposed. Approximate Bayesian Computation (ABC) only requires sampli
Objective: The aim of this study was to examine women's experience of menopausal transition and their expectations and wishes for support from healthcare. Further, to examine their knowledge about menopause and thoughts about current attitudes in healthcare and in society generally. Methods: Data was collected through three focus group interviews with 14 women experiencing menopausal symptoms. The
Over the last three years, national indicator sets and international coalitions for advancement of the well-being economy's ambitions have begun to be developed. This study applies a capital asset, well-being goals and domains, and Sustainable Development Goals (SDGs) framework to evaluate the scope and comprehensiveness of the indicator sets of Iceland, Scotland and New Zealand. Both national obj
Cells are exposed to several types of integrin stimuli, which generate responses generally referred to as "integrin signals", but the specific responses to different integrin stimuli are poorly defined. In this study, signals induced by integrin ligation during cell attachment, mechanical force from intracellular contraction, or cell stretching by external force were compared. The elevated phospho
Transition metals such as copper and zinc are essential elements required for the survival of most organisms, from bacteria to humans. Yet, elevated levels of these elements are highly toxic. The Copper TRansporter protein family (CTRs) represents the only identified copper uptake proteins in eukaryotes and hence serves as key components for the maintenance of appropriate levels of the metal. More
Order Picking in warehouses is often optimized using a method known as Order Batching, which means that one vehicle can be assigned to pick a batch of several orders at a time. There exists a rich body of research on Order Batching Problem (OBP) optimization, but one area which demands more attention is computational efficiency, especially for optimization scenarios where warehouses have unconvent
A tight control over AKT/PKB activation is essential for cells, and they realise this in part by regulating the phosphorylation of Ser473 in the "hydrophobic motif" of the AKT carboxy-terminal region. The RICTOR-mTOR complex (TORC2) is a major kinase for AKT Ser473 phosphorylation after stimulation by several growth factors, in a reaction proposed to require p21-activated kinase (PAK) as a scaffol
Integrin-mediated cell adhesion activates several signaling effectors, including phosphatidylinositol 3-kinase (PI3K), a central mediator of cell motility and survival. To elucidate the molecular mechanisms of this important pathway the specific members of the PI3K family activated by different integrins have to be identified. Here, we studied the role of PI3K catalytic isoforms in β1 integrin-ind
Generic generalisations like ‘Opioids are highly addictive’ are very useful in scientific communication, but they can often be interpreted in many different ways. Although this is not a problem when all interpretations provide the same answer to the question under discussion, a problem arises when a generic generalisation is used to answer a question other than that originally intended. In such ca
Ett av de senaste årens mest uppmärksammade fenomen inom högre utbildning handlar om olika former av gränshållande kring potentiellt upprörande undervisningsinnehåll. Dessa konflikter har lett till intensiv mediabevakning och politisk mobilisering. Men bortom de mest uppmärksammade konflikterna finns återkommande och vardagliga situationer där frågor om exempelvis bild- och språkbruk utmanar stude
Ending the use of unabated coal power is a key climate change mitigation measure. However, we do not know how fast it is feasible to phase-out coal on the global scale. Historical experience of individual countries indicates feasible coal phase-out rates, but can these be upscaled to the global level and accelerated by deliberate action? To answer this question, we analyse 72 national coal power p
Wetland area in agricultural landscapes has been heavily reduced to gain land for crop production, but in recent years there is increased societal recognition of the negative consequences from wetland loss on nutrient retention, biodiversity and a range of other benefits to humans. The current trend is therefore to re-establish wetlands, often with an aim to achieve the simultaneous delivery of mu
We report the discovery of a warm Neptune and a hot sub-Neptune transiting TOI-421 (BD-14 1137, TIC 94986319), a bright (V = 9.9) G9 dwarf star in a visual binary system observed by the Transiting Exoplanet Survey Satellite (TESS) space mission in Sectors 5 and 6. We performed ground-based follow-up observations - comprised of Las Cumbres Observatory Global Telescope transit photometry, NIRC2 adap
Contaminated drinking water (DW) is a major source of exposure to per- and polyfluoroalkyl substances (PFAS) at locations around PFAS production/use facilities and military airports. This study aimed to investigate quantitative relationships between concentrations in DW and serum of nine perfluoroalkyl acids (PFAAs) in Swedish adult populations living near contamination hotspots. Short-chained (PF
We report the confirmation of a transiting planet around the bright weakly active M0.5 V star TOI-1235 (TYC 4384-1735-1, V ≈ 11.5 mag), whose transit signal was detected in the photometric time series of sectors 14, 20, and 21 of the TESS space mission. We confirm the planetary nature of the transit signal, which has a period of 3.44 d, by using precise RV measurements with the CARMENES, HARPS-N,
