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Response to letter to the editor 'Is red cell distribution width a biomarker in risk assessment of diabetes mellitus?

We thank Dr Kurt and colleagues for their comments and interest in our study. High red cell distribution width (RDW) is a new risk factor for cardiovascular disease (CVD), including heart failure, atrial fibrillation and cardiovascular mortality [2-4]. In a recent paper in the Journal of Internal Medicine we reported that low RDW is associated with increased incidence of diabetes [1]. This article

Numerical Predictions of Pressure Drop and Heat Transfer in a Blade Internal Cooling Passage with Continuous/Truncated Ribs

Ribs are often used in the mid-section of internal turbine blades to augment heat transfer from the blade wall to a coolant, but most research works are concerned only with continuous ribs attached to the side walls. In this paper, a turbulent flow and heat transfer of a rectangular passage with continuous and truncated ribs on opposite walls have been predicted numerically. Two types of ribs are

Increased burden on caregivers of having a child with haemophilia complicated by inhibitors.

Having a child with a chronic disease often increases the burden in the family with more hospital visits, treatment administration, and increased worries for the ill child. A cross-sectional, international, multi-centre study in caregivers of children <18 years with haemophilia and inhibitor was performed at Haemophilia Treatment Centres in Sweden, UK, and Canada to evaluate caregivers' burden and

The Life History of 21 Breast Cancers

Cancer evolves dynamically as clonal expansions supersede one another driven by shifting selective pressures, mutational processes, and disrupted cancer genes. These processes mark the genome, such that a cancer's life history is encrypted in the somatic mutations present. We developed algorithms to decipher this narrative and applied them to 21 breast cancers. Mutational processes evolve across a

Orthogonal multiplet bases in SU(N-c) color space

We develop a general recipe for constructing orthogonal bases for the calculation of color structures appearing in QCD for any number of partons and arbitrary N-c. The bases are constructed using hermitian gluon projectors onto irreducible subspaces invariant under SU(N-c). Thus, each basis vector is associated with an irreducible representation of SU(N-c). The resulting multiplet bases are not on

Environmental Hexachlorobenzene exposure and human male reproductive function.

Hexachlorobenzene (HCB) is a persistent environmental fungicide that may disrupt androgen regulation. The aim of this study was to investigate associations between HCB levels and biomarkers of male reproductive function. 589 spouses of pregnant women from Greenland, Poland and Ukraine were enrolled between 2002 and 2004. The men provided semen and blood samples and were interviewed. HCB was measur

"m=1" coatings for neutron guides

A substantial fraction of the price for a supermirror neutron guide system is the shielding, which is needed because of the gamma radiation produced as a result of neutron absorption in the supermirror layers. Traditional coatings have been made of nickel-titanium heterostructures, but Ni and Ti also have a fairly high absorption cross section for cold and thermal neutrons. We examine a number of

How to extract physics from nu (dyn)

In this paper we summarize the properties of nu (dyn) and discuss briefly how the results can be interpreted in terms of a simple pair-production model. The ideas are then illustrated in detail with a PYTHIA simulation study of forward-backward correlations in pp collisions.

miR-187 Is an Independent Prognostic Factor in Breast Cancer and Confers Increased Invasive Potential In Vitro

Purpose: Here, we describe an integrated bioinformatics, functional analysis, and translational pathology approach to identify novel miRNAs involved in breast cancer progression. Experimental Design: Coinertia analysis (CIA) was used to combine a database of predicted miRNA target sites and gene expression data. Using two independent breast cancer cohorts, CIA was combined with correspondence anal

Political Mythmaking and the 2014 Winter Olympics in Sochi: Olympism and the Russian Great Power Myth

The theoretical point of departure of this paper is that the perspective of political myth adds to the understanding of political developments in Russia. The upcoming Olympic Winter Games in Sochi in 2014 are discursively constructed as a manifestation of Russia's return to great power status. In official Russian discourse, there is an encounter between the Russian great power myth and the myth of

Measurement of the production cross section of jets in association with a Z boson in pp collisions at root s=7 TeV with the ATLAS detector

Measurements of the production of jets of particles in association with a Z boson in pp collisions at root s = 7 TeV are presented, using data corresponding to an integrated luminosity of 4.6 fb(-1) collected by the ATLAS experiment at the Large Hadron Collider. Inclusive and differential jet cross sections in Z events, with Z decaying into electron or muon pairs, are measured for jets with transv

Cerebrospinal Fluid Microglial Markers in Alzheimer's Disease: Elevated Chitotriosidase Activity but Lack of Diagnostic Utility

Activated microglial cells, which are the resident macrophages of the central nervous system, surround amyloid beta-plaques in Alzheimer's disease (AD) brains. Inflammation including microglial activation may contribute in AD pathogenesis, and biomarkers for this process may thus be of value to study AD pathogenesis and might facilitate development of therapies targeting these cells. We therefore

Hormonal exposures and the risk of uveal melanoma

Several studies suggest that hormonal mechanisms may be associated with the development of uveal melanoma. Therefore, the association between the risk of uveal melanoma and exposure to hormonal exposures was investigated in a case-control study from nine European countries. Incident cases of uveal melanoma were frequency-matched to population and hospital controls by country, age, and sex. Female

Investigation of different particle sizes on superhydrophobic surfaces made by rapid expansion of supercritical solution with in situ laser diffraction (RESS-LD)

In situ laser diffraction, scanning electron microscopy (SEM) imaging, and thermography have been used to investigate particle formation and particle size distribution of alkyl ketene dimer (AKD) produced by rapid expansion of supercritical solution (RESS). The investigated RESS process is based on an earlier reported method to prepare superhydrophobic coatings. Spray distance, pre-expansion tempe

Influence of a 3-Year Exercise Intervention Program on Fracture Risk, Bone Mass, and Bone Size in Prepubertal Children

Published prospective pediatric exercise intervention studies are short term and use skeletal traits as surrogate endpoints for fractures, whereas other reports infer exercise to be associated with more trauma and fractures. This prospective, controlled exercise intervention study therefore followed both skeletal traits and fracture risk for 36 months. Fractures were registered in children aged 7

Coffee prevents early events in tamoxifen-treated breast cancer patients and modulates hormone receptor status.

PURPOSE: Whether coffee modulates response to endocrine therapy in breast cancer patients is currently unknown. The CYP1A2 and CYP2C8 enzymes contribute to tamoxifen and caffeine metabolism. The purpose was to investigate the impact of coffee consumption on tumor characteristics and risk for early events in relation to breast cancer treatment and CYP1A2 and CYP2C8 genotypes. METHODS: Questionnaire

Increasing iron concentrations in surface waters - a factor behind brownification?

Browning of inland waters has been noted over large parts of the Northern hemisphere and is a phenomenon with both ecological and societal consequences. The increase in water color is generally ascribed to increasing concentrations of dissolved organic matter of terrestrial origin. However, oftentimes the increase in water color is larger than that of organic matter, implying that changes in the c