The molecular characteristics of the pseudoautosomal region (PAR) of sex chromosomes remain elusive. Despite significant genome-sequencing efforts, the PAR of highly differentiated avian sex chromosomes remains to be identified. Here we use linkage analysis together with whole-genome re-sequencing to uncover the 630-kb PAR of an ecological model species, the collared flycatcher. The PAR contains 2

The biology centered around the TGF-beta type I receptor Activin Receptor-Like Kinase (ALK)1 (encoded by ACVRL1) has been almost exclusively based on its reported endothelial expression pattern since its first functional characterization more than two decades ago. Here, in efforts to better define the therapeutic context in which to use ALK1 inhibitors, we uncover a population of tumor-associated

The key concepts and reference points of International Relations (IR) are informed by a sedentarist worldview anchored on the territorial state. IR’s conception of its subject-matter is thus ‘static’ in both senses of the word: state-centric and immobile. One of the consequences of this sedentarist worldview has been a neglect of the world’s nomads. Defined by their spatial mobility, nomads have b

Pieces included:George Enescu: Legende für Trompete und KlavierStaffan Storm: "Three Autumns" für Trompete und Klavier (2016) IntervalTurnage. Autumn Aubade (World Premiere) Pöntinen. New work (World Premiere) Bernstein. Rondo for LifeyHK (Heinz Karl) Gruber: "Bossa Nova" für Kammerensemble, op. 21 (1968)Roland Pöntinen: Prélude d’automne Op.28, No.8 (2018)Florent Schmitt: Suite für Trompete und K

Drawing on the contributions presented in the special issue “God’s Influencers: How Social Media Users Shape Religion and Pious Self-Fashioning”, this introduction explores resonances and dissonances between the six articles: First, I reconsider the online/offline connection in relation to the religious actors examined. Then, I articulate a post techno-utopian vision of religion online, identifyin

INTRODUCTION: Cardiovascular drug use may help prevent dementia; however, current evidence is mixed. Using a case–control design, we investigated the association between duration and combination of multiple cardiovascular drug classes and incident dementia. METHODS: From the Swedish national registers, we included 88,065 incident dementia cases aged ≥ 70 at diagnosis between 2011 and 2016 and 880,

Sjukdomsberättelser om bröstcancer kan bidra med nya aspekter i utvecklingen av individualiserad cancerrehabiliteringBröstcancer är den vanligaste cancersjukdomen bland kvinnor världen över [1, 2]. I Sverige drabbas mer än var tionde kvinna av bröstcancer under sitt liv [3]. Utifrån att prognosen vid bröstcancer har förbättrats, är det allt fler kvinnor som överlever eller lever längre med sin sju

Polycentric governance has often been theorized as a desirable model for digital ecosystems due to its potential to spur innovation and enhance adaptability. However, in decentralised healthcare systems like Sweden's, low innovation rates and interoperability issues persist. This paper examines Sweden's efforts to achieve national digital health goals within its decentralised model. Analysing qual

The APOE4 allele is the strongest genetic risk factor for sporadic Alzheimer's disease (AD). While APOE4 is strongly associated with amyloid-beta (Aβ), its relationship with tau accumulation is less understood. Studies evaluating the role of APOE4 on tau accumulation showed conflicting results, particularly regarding the independence of these associations from Aβ load. In this study, we examined t

This chapter revisits Iver Neumann’s seminal book The Uses of the Other (1999) in order to unpack its assumptions about collective identity formation in world politics. After having situated this work in its contemporary context and pointed to its significance, the chapter tries to demonstrate the extent to which its basic assumptions about collective identity formation replicates those that went

Contact nursing services have been implemented in Swedish cancer care to increase healthcare quality. Too little is known about the content and quality of these services and the organizational prerequisites provided to contact nurses. The aim of this study was to explore contact nurses’ perceptions of their services and organizational prerequisites, as well as the connection between organizational

Introduction: Little is known regarding the comparison of cardiovascular and kidney outcomes between lupus nephritis (LN) and other etiologies of chronic kidney disease (CKD). Methods: Using data from the Swedish Renal Registry (2006–2021), we compared long-term outcomes between patients with LN-CKD and patients with CKD due to primary glomerular diseases (PGD) and other CKD causes (Other-CKD, mai

A glimpse into a better world: The 4th Symphony Concert C with the world-class trumpeter Håkan Hardenberger and Jörg Widmann, the principal guest conductor of the NDR Radio Philharmonic, is about nothing less.While the warlike tones in Felix Mendelssohn Bartholdy's "Scottish" symphony finally give way to a roaring hymn of joy, Jörg Widmann's "Towards Paradise" strives for a utopian state of limbo.

BACKGROUND: Currently, there are no therapies targeting specific pathogenic pathways in myocarditis. IL (interleukin)-1 blockade has shown promise in preclinical studies and case reports. We hypothesized that blockade of IL1RAP (IL-1 receptor accessory protein), a shared subunit of the IL-1, IL-33, and IL-36 receptors, could be more efficient than IL-1 blockade alone. METHODS: We induced coxsackie

Biopharmaceuticals, of which monoclonal antibodies are a mainstay, have revolutionized healthcare by enabling treatments with high precision and efficacy. However, their established manufacturing processes, particularly the downstream process, are complex, resource-intensive, and expensive, limiting global access to these drugs. This thesis examines how a more efficient, sustainable, and thus less

OBJECTIVE: Systemic inflammatory autoimmune diseases (SIADs) such as systemic lupus erythematosus (SLE), primary Sjögren disease (pSS), and idiopathic inflammatory myopathies (myositis) are complex conditions characterized by shared circulating autoantibodies and clinical manifestations, including skin rashes, among others. This study was aimed at elucidating the genetics underlying these common f

OBJECTIVES: To calculate a polygenic risk score (PRS) based on single nucleotide variants (SNVs) previously associated with primary Sjögren's disease (SjD) with genome-wide significance, and determine the genetic risk for SjD stratified by antibodies, sex and age at diagnosis.METHODS: Patients with SjD (n = 1065) were genotyped using Illumina OmniExpressExome chip. Control genotype data were avail