Brain lactate concentration is higher during wakefulness than in sleep. However, it is unknown why arousal is linked to an increase in brain lactate and why lactate declines within minutes of sleep. Here, we show that the glymphatic system is responsible for state-dependent changes in brain lactate concentration. Suppression of glymphatic function via acetazolamide treatment, cisterna magna punctu

Myelin regeneration can occur spontaneously in demyelinating diseases such as multiple sclerosis (MS). However, the underlying mechanisms and causes of its frequent failure remain incompletely understood. Here we show, using an in-vivo remyelination model, that demyelinated axons are electrically active and generate de novo synapses with recruited oligodendrocyte progenitor cells (OPCs), which, ea

Metabolically, the brain is a highly active organ that relies almost exclusively on glucose as its energy source. According to the astrocyte-to-neuron lactate shuttle hypothesis, glucose is taken up by astrocytes and converted to lactate, which is then oxidized by neurons. Here we show, using two-photon imaging of a near-infrared 2-deoxyglucose analogue (2DG-IR), that glucose is taken up preferent

The glymphatic system is a recently discovered macroscopic waste clearance system that utilizes a unique system of perivascular tunnels, formed by astroglial cells, to promote efficient elimination of soluble proteins and metabolites from the central nervous system. Besides waste elimination, the glymphatic system also facilitates brain-wide distribution of several compounds, including glucose, li

Myelination by oligodendrocytes is a highly specialized process that relies on intimate interactions between the axon and the oligodendrocytes. Astrocytes have an important part in facilitating myelination in the CNS, however, comparatively less is known about how they affect myelination. This review therefore summarizes the literature and explores lingering questions surrounding differences betwe

Myelination is essential for rapid impulse conduction in the CNS, but what determines whether an individual axon becomes myelinated remains unknown. Here we show, using a myelinating coculture system, that there are two distinct modes of myelination, one that is independent of neuronal activity and glutamate release and another that depends on neuronal action potentials releasing glutamate to acti

The evolution of assortative mating is a key part of the speciation process. Stronger assortment, or greater divergence in mating traits, between species pairs with overlapping ranges is commonly observed, but possible causes of this pattern of reproductive character displacement are difficult to distinguish. We use a multidisciplinary approach to provide a rare example where it is possible to dis

This chapter deals with the male appropriation of motherhood as a metaphor for transformation in religious texts and practices. Particular attention is given to its historical uses and modern reception in the Daoist alchemical traditions. Through a textual study of the central Daoist text the Daodejing, gendered metaphors, particularly relating to motherhood and infancy are identified and analysed

This paper investigates the use of Ancient Greek imagery in the marketing of male grooming products. Based on a case study of the cosmetics brand HOMMER, the paper analyses how elements such as scent and product ingredients combined with a visual profile and storytelling, provide consumers with elements for an experientially based identity creation. Based on psychological and archaeological theory

Introduction to modern literary uses of Homer

To investigate the symbiotic interaction of Trichoderma harzianum Rifai on Chenopodium quinoa Willd. in isolation, we studied axenic co-culture of the T. harzianum isolates T-22 and BOL-12QD and the C. quinoa cultivars Kurmi and Maniqueña real. Neither T-22 nor BOL-12QD affected seedling growth during two days of co-culture in the early growth phase of rapid primary root extension. However, after To investigate the symbiotic interaction of Trichoderma harzianum Rifaion Chenopodium quinoa Willd. in isolation, we studied axenic co-culture of the T. harzianum isolates T-22 and BOL-12QD and the C. quinoa cultivars Kurmi andManiqueña real. Neither T-22 nor BOL-12QD affected seedling growth during two days of co-culture in the early growth phase of rapid primary root extension.However, after lon