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Lack of representativeness may distort the associations of alcohol with CVD mortality, and may underestimate health hazards among those with cumulatively the least healthy lifestyles. Read the paper at https://journals.lww.com/epidem/Fulltext/2021/03000/Is_Cohort_Represent…
Advice regarding the analysis of observational studies of exposure effects usually is against adjustment for factors that occur after the exposure, as they may be caused by the exposure (or mediate the effect of exposure on outcome), so potentially leading to collider stratification bias. However, such factors could also be caused by unmeasured confounding factors, in which case adjusting for them
https://www.lupop.lu.se/article/adjust-or-not-adjust-when-confounder-only-measured-after-exposure - 2025-11-05
Mediation analysis, which started in the mid-1980s, is used extensively by applied researchers. Indirect and direct effects are the part of a treatment effect that is mediated by a covariate and the part that is not. Subsequent work on natural indirect and direct effects provides a formal causal interpretation, based on cross-worlds counterfactuals: outcomes under treatment with the mediator set t
Patient registries are an established methodology in health services research. Since more than 150 years, registries collect information concerning groups of similar patients to answer research questions. Elaborated recommendations about an appropriate development and an efficient operation of registries are available. However, the scene changes rapidly. Read the paper at https://www.thieme-connec
https://www.lupop.lu.se/article/recent-trends-patient-registries-health-services-research - 2025-11-05
Collaboration and the sharing of knowledge is at the heart of Open Science (OS). However, we need to know that the knowledge we find and share is really what it purports to be; and we need to know that the authors we hope to collaborate with are really the people they claim to be. Read the paper at https://direct.mit.edu/dint/article/3/1/64/94911/Open-Science-A-Questio…
https://www.lupop.lu.se/article/open-science-question-trust - 2025-11-05
Here, we describe the new MSBase pregnancy, neonatal outcomes and women’s health registry. We provide the rationale for, and detailed description of, the variables collected within the registry, together with data acquisition details. Read the paper at https://journals.sagepub.com/doi/pdf/10.1177/17562864211009104
https://www.lupop.lu.se/article/msbase-pregnancy-neonatal-outcomes-and-womens-health-registry - 2025-11-05
Generalizability methods are increasingly used to make inferences about the effect of interventions in target populations using a study sample. Most existing methods to generalize effects from sample to population rely on the assumption that subgroup-specific effects generalize directly. However, researchers may be concerned that in fact subgroup-specific effects differ between sample and populati
https://www.lupop.lu.se/article/generalizability-subgroup-effects - 2025-11-05
An estimated 40% of pregnancies globally are unintended. Measurement of pregnancy intention in low- and middle-income countries relies heavily on surveys, notably Demographic and Health Surveys (DHS), yet few studies have evaluated survey questions. Read the paper at https://pophealthmetrics.biomedcentral.com/articles/10.1186/s12963-020-…
https://www.lupop.lu.se/article/pregnancy-intention-data-completeness-quality-and-utility-population-based-surveys - 2025-11-05
Clinical registries that monitor and review outcomes for patients with cystic fibrosis have existed internationally for many decades. However, their purpose continues to evolve and now includes the capability to support clinical effectiveness research, clinical trials and Phase IV studies, and international data comparisons and projects. Read the paper at https://www.sciencedirect.com/science/arti
https://www.lupop.lu.se/article/redesign-australian-cystic-fibrosis-data-registry-multidisciplinary-collaboration - 2025-11-05
The PARTNER project (Paediatric Rare Tumours Network - European Registry) was launched in 2016. PARTNER aims to create a European Registry dedicated to children and adolescents with very rare tumors (VRT). It links existing national registries and provides a registry for those countries in which a VRT registry has not yet been created. Read the paper at https://onlinelibrary.wiley.com/doi/full/10.
Systems models, which by design aim to capture multi-level complexity, are a natural choice of tool for bridging the divide between social epidemiology and causal inference. In this commentary, we discuss the potential uses of complex systems models for improving our understanding of quantitative causal effects in social epidemiology. Read the essay at http://dx.doi.org/10.1136/jech-2019-213052
https://www.lupop.lu.se/article/complex-systems-models-causal-inference-social-epidemiology - 2025-11-05
In this paper, we describe a newly developed estimation method that fits the additive hazards models to general two-phase sampling studies along with the R package addhazard that implements it. Read the paper at https://link.springer.com/article/10.1007/s10654-021-00739-3
https://www.lupop.lu.se/article/estimating-hazard-rate-difference-case-cohort-studies - 2025-11-05
We sought to understand why researchers do or do not regularly use DAGs by surveying practicing epidemiologists and medical researchers on their knowledge, level of interest, attitudes, and practices towards the use of causal graphs in applied epidemiology and health research. Read the paper at https://link.springer.com/article/10.1007%2Fs10654-021-00771-3
We propose to extend our previous approach for the joint analysis of marginal summary statistics to incorporate prior information via a hierarchical model (hJAM). Read the paper at https://doi.org/10.1093/aje/kwaa287
The VALIDATE-SWEDEHEART trial was a registry-based randomized trial comparing bivalirudin and heparin in patients with acute myocardial infarction undergoing percutaneous coronary intervention. It showed no differences in mortality at 30 or 180 days. This study examines how well the trial population results may generalize to the population of all screened patients with fulfilled inclusion criteria
https://www.lupop.lu.se/article/assessing-external-validity-validate-swedeheart-trial - 2025-11-05
Aims: To estimate the prevalence of parental substance use disorder (PSUD) in the general population based on young adults' reports adjusted for non-participation using register-based indicators of PSUD. Read the paper at https://europepmc.org/article/med/33878599
A large cohort, consisting of versatile individual-level phenotype and genotype data, can be constructed by integrating data from several biobanks and health data registers in Finland. Co-operation with biobanks is straightforward. However, long time periods need to be reserved when biobank resources are linked with national register data. Read the paper at https://journals.sagepub.com/doi/full/10
About 30 million people in the EU and USA, respectively, suffer from a rare disease. Driven by European legislative requirements, national strategies for the improvement of care in rare diseases are being developed. Read the paper at https://ojrd.biomedcentral.com/articles/10.1186/s13023-021-01831-3
In a prospective study, we sought to determine acceptability of linkage of administrative and clinical trial data among Canadian patients and Research Ethics Boards (REBs). The goal is to develop a more harmonized approach to data, with potential to improve clinical trial conduct through enhanced data quality collected at reduced cost and inconvenience for patients. Read the paper at https://www.n
Du kommer att samla in och ställa samman kunskap om forskningsdata och dess hantering i biobankskohorter, såväl i Umeå som nationellt. Målet är att peka ut förbättringsområden, för förbättrade och förenklade flöden för forskningen. Parallellt kommer du att arbeta med att ge konkret stöd till forskare inom olika biobanksprojekt. Läs mer och ansök på https://www.umu.se/jobba-hos-oss/lediga-jobb/fors
