Tumor Signatures of Physical Fitness : Insights from a Preclinical Model
Purpose: Cardiorespiratory fitness (CRF) and muscle strength are associated with cancer risk/mortality in adults. However, there is yet no evidence for pediatric tumors. This study investigated the association of CRF and muscle strength with several tumor-related phenotypes in an aggressive childhood malignancy, high-risk neuroblastoma (HR-NB). Methods: Twelve mice bearing orthotopic HR-NB were st
