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Immunoglobulin constant heavy G chain (IGHG) gene polymorphisms are associated with atopy and can be determined by the serum Gm allotypes. We studied whether certain polymorphisms are related to asthma severity and to the extent or intensity of allergic sensitization in asthmatic subjects followed from childhood to young middle age. Fifty-five subjects (28 males) with childhood asthma were all fo
The issue of strengthening local research capacity in Africa is again high on the health and development agenda. The latest initiative comes from the Wellcome Trust. But when it comes to capacity development, one of the chief obstacles that health sectors in the region must confront is the migration of health professionals to countries that offer more lucrative opportunities, like those in western
The model for permanent deformation in asphalt concrete (AC) layers used in the Mechanistic-Empirical Pavement Design Guide (MEPDG) was evaluated. Two instrumented flexible pavements were subjected to heavy vehicle simulator testing at three constant temperatures. Permanent deformation modelling was carried out using the MEPDG software v1.003 at the highest accuracy level. The nationally calibrate
Popular Abstract in Swedish SVENSK SAMMANFATTNING (SUMMARY IN SWEDISH) Hematopoes och leukemi Hematopoes är benämningen på den process vari alla blodceller genom hela livet kontinuerligt utvecklas i benmärgen, samt vid bildandet av lymfocyter även i lymfkörtlarna. Varje dygn bildas det ca 1012 nya celler i benmärgen för att ersätta uttjänta blodceller som dör och bryts ned. Ett litet antal stamcelWilms’ tumour gene 1 (WT1) encodes a zinc-finger transcription factor functioning as a key regulator in organ development. WT1 was first identified as a tumour suppressor gene due to its inactivation in Wilms’ tumour cases, a childhood kidney cancer. In adult tissues WT1 expression is restricted to few organs, but various forms of cancers express high WT1 levels, suggesting an oncogenic potential
The various types of treatment of lymphedema are under discussion and there has been some controversy regarding liposuction for lymphedema. Although it is clear that conservative therapies such as complex decongestive therapy (CDT) and controlled compression therapy (CCT) should be tried in the first instance, options for the treatment of late-stage lymphedema that is not responding to such treatm
In this paper we argue that the emergence of the dominant model of university organization, which is characterized by a large agglomeration of many (often loosely affiliated) small research groups, might have an economic explanation that relates to the features of the scientific production process. In particular, we argue that there are decreasing returns to scale on the level of the individual re
Lärande sker i sociala sammanhang. Genom nätet är klassrummet idag globalt. Tusentals universitet, skolor och lärare i världen delar idag med sig av kursmaterial, föreläsningar, experiment, reportage och bilder så att andra kan återanvända materialet i sin undervisning.
Bone mineral density (BMD) is the most widely used predictor of fracture risk. We performed the largest meta-analysis to date on lumbar spine and femoral neck BMD, including 17 genome-wide association studies and 32,961 individuals of European and east Asian ancestry. We tested the top BMD-associated markers for replication in 50,933 independent subjects and for association with risk of low-trauma
The Wenlock (middle Silurian) Eramosa Lagerstatte of the Bruce Peninsula, Ontario, Canada, is becoming known for its rich and diverse faunas, different preservational styles, and a combination of soft-body preservation associated with shelly body and trace fossils. Sampling for scolecodonts-the jaws of polychaete annelids-has yielded unique material. Hindenites parkheadensis new species is describ
Dekkera bruxellensis is a non-conventional Crabtree-positive yeast with a good ethanol production capability. Compared to Saccharomyces cerevisiae, its tolerance to acidic pH and its utilization of alternative carbon sources make it a promising organism for producing biofuel. In this study, we developed an auxotrophic transformation system and an expression vector, which enabled the manipulation o
Arid and semiarid Middle Eastern countries generally, and Syria in particular, face serious water shortage problems and challenges with water sustainability. Climate change, population growth, and economic development play a major role in decreasing available water resources per capita. This, in turn, has great impact on domestic, agricultural, and industrial water use. In this study, marginal and
The thesis discusses closed-loop control of the hypnotic and the analgesic components of anesthesia. The objective of the work has been to develop a system which independently controls the intravenous infusion rates of the hypnotic drug propofol and analgesic drug remifentanil. The system is designed to track a reference hypnotic depth level, while maintaining adequate analgesia. This is complicat
Continuity of care is one of the core values of family medicine and both patients and doctors consider it a vital aspect of the care of patients with chronic diseases. In 2009 a national health care reform was implemented in primary care in Sweden. This study compared the longitudinal continuity of care in primary care before and after this reform in 7121 adult diabetes patients living in Malmö. O
Background: Efficient utilization of both glucose and xylose is necessary for a competitive ethanol production from lignocellulosic materials. Although many advances have been made in the development of xylose-fermenting strains of Saccharomyces cerevisiae, the productivity remains much lower compared to glucose. Previous transcriptional analyses of recombinant xylose-fermenting strains have mainl
The main advantage of a heated-grid reactor for studying pyrolysis kinetics of solid fuel samples is that high heating rates of up to 1000 K/s can be obtained. However, one of the concerns is whether the temperature distribution over the grid material is uniform and whether the presence of a thermocouple welded to the grid causes any measurement errors. Biomass samples were placed on the heated-gr
The relation between mission, religious conversion and identity construction is the subject of my paper. On a concrete level, I discuss the Catholic mission and conversions in Scandinavia from the middle of nineteenth century to the present time. Up to the Second Vatican Council (1962-65), the Catholic Church strongly emphasised its claim to be the only true Church, and as a consequence, all non-C
The influence of electrostatic interactions on the dynamic properties of complexes containing DNA and mixtures of cationic- (DDA) and zwitterionic (DLPC) lipids are studied by means of NMR. The systems are arranged in lamellar membrane stacks intercalated by DNA molecules. This is confirmed by 31P-NMR, where a superposition of an axially symmetric powder pattern arising from the phospholipid membr
