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When Are Single Reader Evaluations Insufficient in Teledermoscopic Assessments? : Analyses of a Retrospective Cohort Study
Background: Teledermoscopy (TDS) emerges as an efficient tool for diagnosing skin lesions. In Sweden, double reading is the standard of care, but risk factors for misdiagnosis or mismanagement using single reader evaluations (SRE) are not well-studied. This study aimed to assess the accuracy of SRE compared with the gold standard in TDS. Methods: This retrospective cohort study involved 1,997 TDS
Utredningsarbete i barnavården : centrala utgångspunkter och förändringar
Histopathological Diagnostic Discordance between Punch Biopsies and Final Diagnostic Excisions of Cutaneous Squamous Cell Carcinoma : Analysis of 737 Cases
The recommended treatment for cutaneous squamous cell carcinoma is surgical excision. An initial punch biopsy is often performed as an aid to diagnosis. A retrospective registry-based study was performed to assess histopathological concordance of punch biopsy of cutaneous squamous cell carcinoma and subsequent excision. Analysis of 737 punch biopsies and subsequent matched excisions was performed.
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Utredningar som leder till förslag om tvångsvård
Breast cancer and its genetic heterogeneity at single cell level: A concise perspective of cellular architecture and taxonomy
Dealing with the heterogeneity of breast tumors and treating breast cancer patients pose a great challenge. The heterogeneity within and between tumors indicates that each case of breast cancer may have a good prognosis and could benefit from tailored therapies. Breast cancer is a condition that undergoes changes as the tumor progresses and metastasizes, which presents further challenges for imple
Physical health in young males and risk of chronic musculoskeletal, cardiovascular, and respiratory diseases by middle age : A population-based cohort study
BACKGROUND: Cardiovascular, respiratory, and musculoskeletal disease are among the leading causes of disability in middle-aged and older people. Health and lifestyle factors in youth have known associations with cardiovascular or respiratory disease in adulthood, but largely unknown associations with musculoskeletal disease.METHODS AND FINDINGS: We included approximately 40,000 18-year-old Swedish
Marcus Aurelius i Eleusis
Inferring North American Holocene Land Cover Change using Paleoecological Evidence
Climate-vegetation feedbacks (CVFs) can amplify or mitigate climate variations. These feedbacks operate at multiple timescales. Fast processes such as leaf-scale carbon fluxes operate at sub-annual timescales, while slow processes, driven by changes in forest composition and structure, occur over decadal and longer timescales. Slow processes are rarely directly observed from instrumental data; yet
Om försörjning på ålderdomen
Remissyttrande: Kompletterande bestämmelser till EU:s mediefrihetsförordning (Ds 2024:28)
Holocene Land Cover Change in North America: Trends, Drivers, and Feedbacks
Land cover governs biogeophysical and biogeochemical feedbacks between the land surface and atmosphere. Holocene vegetation-atmosphere interactions are of particular interest, both to understand the climate effects of intensifying human land use and as a possible explanation for the Holocene Conundrum, a widely studied mismatch between simulated and reconstructed temperatures. Progress addressing
Deep Learning for Resolving 3D Microstructural Changes in the Fibrotic Liver
Portal hypertension, a life-threatening complication of cirrhosis,is largely triggered by increased intrahepatic vascular resistance.Fibrosis, regenerative nodule formation, intrahepatic angiogenisis and sinusoidalremodelling are classical mechanisms that account for increasedintrahepatic vascular resistance in cirrhosis. Our study leverages highresolution3D synchrotron radiation-based microtomogr
Conceptual design of a 3rd harmonic cavity system for the LNLS electron storage ring
The installation of a second RF cavity in the UVX electron storage ring at the Brazilian Synchrotron Light Laboratory (LNLS) at the end of 2003 brought about longitudinal instabilities driven by one of the HOMs of the new cavity. Even though the operational difficulties related to these unstable modes were successfully overcome by means of a combination of cavity tuning (using temperature and plun
Advances in beam orbit stability at the LNLS electron storage ring
We describe recent efforts made at the Brazilian Synchrotron Light Source (LNLS) to improve beam orbit stability. The main driving force is the high positional stability required by some specific experiments and particularly by a high resolution undulator beamline which is being built at LNLS. Recent steps taken to improve orbit stability include the development of x-ray BPMs to measure the vertic
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Holocene land cover change in North America: continental trends, regional drivers, and implications for vegetation-atmosphere feedbacks
Land cover governs the biogeophysical and biogeochemical feedbacks between the land surface and atmosphere. Holocene vegetation-atmosphere interactions are of particular interest, both to understand the climate effects of intensifying human land use and as a possible explanation for the Holocene Conundrum, a widely studied mismatch between simulated and reconstructed temperatures. Progress has bee
Who Is Responsible? Social Identity, Robot Errors and Blame Attribution
This paper argues that conventional blame practices fall short of capturing the complexity of moral experiences, neglecting power dynamics and discriminatory social practices. It is evident that robots, embodying roles linked to specific social groups, pose a risk of reinforcing stereotypes of how these groups behave or should behave, so they set a normative and descriptive standard. In addition,
Developing a guide for sustainable healthcare practice : A case study from the Swedish Society of Medicine
Introduction: Although climate change has been consistently identified as one of the greatest threats to humans, many clinicians do not feel prepared to address climate change with patients and medical school curricula still have very little coverage of its health consequences. At the same time, health care providers have been shown to be trusted voices and are therefore well suited to help build
