Objective: To study prescription patterns of biological treatment in rheumatoid arthritis ( RA) patients in southern Sweden, a region with no formal or economic restrictions for the use of biological treatment in rheumatological diseases. Specifically, we studied conformity with the national Swedish guidelines for biologics in RA. Methods: Rheumatologists in southern Sweden contribute to a volunta

I kanadensiska mi'kmaqberättelser, vilka nedtecknades under tiden som gruppen levde som jägare och samlare, finna flera skildringar av djur som flitiga agenter. Det finns till och med berättelser om äktenskap mellan människor och djur som dock alltid slutar olyckligt. Hur ska dessa berättelser läsas? Som nonsens eller säger de något om gränser och förhållningssätt till det vi i väst dikotomiserat

Trigonal-planar, middle transition metal diiminato-imido complexes do not exhibit high-spin states, as might be naively expected on the basis of their low coordination numbers. Instead, the known Fe(III), Co(III), and Ni(III) complexes exhibit S = (3)/(2), S = 0, and S = (1)/(2), ground states, respectively. Kohn-Sham DFT calculations have provided a basic molecular orbital picture of these compou

Urothelial carcinoma shows frequent amplifications at 6p22 and 1q21-24. The main target gene at 6p22 is believed to be E2F3, frequently co-amplified with CDKAL1 and SOX4. There are however reports on 6p22 amplifications that do not include E2F3. Previous analyses have identified frequent aberrations occurring at 1q21-24. However, due to complex rearrangements it has been difficult to identify spec

Abstract COPD is a major cause of chronic morbidity and mortality throughout the world. It is a preventable and treatable disease. Smoking is the most commonly encountered risk factor for COPD and the habit now unfortunately starts at earlier ages than before. There is a strong necessity to diagnose COPD in early stages before symptoms present themselves. MRI with hyperpolarized 3He using diffusio

Background: Migration is important for the metastatic capacity and thus for the malignancy of cancer cells. There is limited knowledge on regulatory factors that promote the migration of neuroblastoma cells. This study investigates the hypothesis that protein kinase C (PKC) isoforms regulate neuroblastoma cell motility. Methods: PKC isoforms were downregulated with siRNA or modulated with activato

This paper concerns mathematical modeling and computational fluid dynamics of back-shocking during hollow fibre ultrafiltration of dextran T500. In this paper we present a mathematical model based on first Principles, i.e., solving the Navier-Stokes equation along with the continuity equation for both the solute and the solvent. We investigate the validity of the estimate On the optimal back-shock

Background: Dercum's disease is characterised by pronounced pain in the adipose tissue and a number of associated symptoms. The condition is usually accompanied by generalised weight gain. Many of the associated symptoms could also be signs of depression. Depression in Dercum's disease has been reported in case reports but has never been studied using an evidence-based methodology. The aim of this

Recent years molecular imprinting has received considerable attention as an excellent and simple approach to recognize small molecules and bioactive substances. The aim of this study is to prepare the bilirubin-imprinted supermacroporous cryogels which can be used for the adsorption of bilirubin from human plasma. N-methacryloyl(L)-tyrosinemethylester (MAT) was chosen as the preorganization monome

Planar ground float glass surfaces and the surfaces within holes are polished using fluid jet polishing (FJP) in order to improve their visual appearance or material strength. The large flexibility of FJP makes it suitable for polishing holes and other complex geometries. The influence of polishing speed, incident angle, distance, pressure, abrasive concentration, and nozzle diameter are investiga

SUMMARY Because of the strong causal relationship between persistent infections of human papillomavirus (HPV) and cervical intraepithelial neoplasia (CIN) and cancer, HPVtesting has been proposed for improvement of cervical screening programs, including triaging and follow-up after treatment for CIN. We developed two new methods for HPV-testing with genotyping: A high-throughput HPV genotyping met

Numerous studies have been performed aimed at limiting the extent of retinal injury after ischemia, but there is still no effective pharmacological treatment available. The aim of the present study was to examine the role of tumor necrosis factor (TNF)α and its receptors (TNF-R1 and TNF-R2), especially considering the neuroretina and the retinal vasculature since the retinal blood vessels are key

Recension av Marie Moutier, Wehrmachtsoldaternas brev från fronten 1939–1945.

We examined the effects of 50-Hz magnetic fields in the range of flux densities relevant to our current environmental exposures on action potential (AP), after-hyperpolarization potential (AHP) and neuronal excitability in neurons of land snails, Helix aspersa. It was shown that when the neurons were exposed to magnetic field at the various flux densities, marked changes in neuronal excitability,

Objective To assess the impact of the indication for a previous caesarean section on the outcome of a subsequent delivery. Design Population-based cohort study. Setting Sweden. Population Women with two deliveries between 1987 and 2007 identified using the Swedish Medical Birth Registry. Methods The outcome of 69 133 pregnancies after one caesarean section was compared with the outcome of 487 610

Prior twin and adoption studies have demonstrated the importance of both genetic and shared environmental factors in the etiology of criminal behavior (CB). However, despite substantial interest in life-course theories of CB, few genetically informative studies have examined CB in a developmental context.