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Bias Analysis Gone Bad

We identified 3 examples of suboptimal bias analysis, one for each common bias. For each, we describe the original research and its bias analysis, compare the bias analysis with good practices, and describe how the bias analysis and research findings might have been improved. Read the paper at https://academic.oup.com/aje/article/190/8/1604/6189735

https://www.lupop.lu.se/article/bias-analysis-gone-bad - 2025-10-01

Propensity Score Weighting and Trimming Strategies for Reducing Variance and Bias of Treatment Effect Estimates: A Simulation Study

To extend previous simulations on the performance of propensity score (PS) weighting and trimming methods to settings without and with unmeasured confounding, Poisson outcomes, and various strengths of treatment prediction (PS c statistic), we simulated studies with a binary intended treatment T as a function of 4 measured covariates. Read the paper at https://academic.oup.com/aje/article/190/8/16

https://www.lupop.lu.se/article/propensity-score-weighting-and-trimming-strategies-reducing-variance-and-bias-treatment-effect - 2025-10-01

Data from national health registers as endpoints for the Tromsø Study: Correctness and completeness of stroke diagnoses

The benefits of using data from national registers as endpoints in epidemiological studies must be weighed against the impact of potentially decreased data quality. Read the paper at https://journals.sagepub.com/doi/full/10.1177/14034948211021191

https://www.lupop.lu.se/article/data-national-health-registers-endpoints-tromso-study-correctness-and-completeness-stroke-diagnoses - 2025-10-01

A cautionary note on a recently proposed sensitivity analysis for unmeasured confounding

Unmeasured confounding is a common threat to the validity of observational studies. In practice, confounding bias may arise from both confounders that are completely unmeasured and from confounders that are measured with error. Read the paper at https://academic.oup.com/ije/article/50/3/711/6048186

https://www.lupop.lu.se/article/cautionary-note-recently-proposed-sensitivity-analysis-unmeasured-confounding - 2025-10-01

Reflection on modern methods: a common error in the segmented regression parameterization of interrupted time-series analyses

Interrupted time-series (ITS) designs are a robust and increasingly popular non-randomized study design for strong causal inference in the evaluation of public health interventions. Read the paper at https://academic.oup.com/ije/article/50/3/1011/5937253

https://www.lupop.lu.se/article/reflection-modern-methods-common-error-segmented-regression-parameterization-interrupted-time-series - 2025-10-01

A snapshot of European registries on Chronic Kidney Disease patients not on Kidney Replacement Therapy

We report the current status of CKD registries in Europe in relation to their data collection on patients not on KRT so that in the future we may investigate to what extent also their data may be used for similar purposes, like collaborative research on CKD trajectories and patient outcomes. Read the paper at https://academic.oup.com/ndt/advance-article/doi/10.1093/ndt/gfab252/63…

https://www.lupop.lu.se/article/snapshot-european-registries-chronic-kidney-disease-patients-not-kidney-replacement-therapy - 2025-10-01

Completeness of esophageal cancer diagnosis in the Finnish Cancer Registry and hospital discharge registry, a nationwide study in Finland

The aim of this study was to explore the potential misclassification and evaluate the completeness of esophageal cancer diagnoses in the FCR and HILMO, considering misclassification. Read the paper at https://www.tandfonline.com/doi/full/10.1080/0284186X.2020.1792547

https://www.lupop.lu.se/article/completeness-esophageal-cancer-diagnosis-finnish-cancer-registry-and-hospital-discharge-registry - 2025-10-01

Reliability of self-reported questionnaire for epidemiological investigation of Helicobacter pylori eradication in a population-based cohort study

General population-based cohort studies provide solid evidence on mass Helicobacter pylori (HP) eradication effects. Self-reported questionnaires are occasionally used in such studies to ascertain the HP eradication history. However, reports on the reliability of these questionnaires are lacking. Read the paper at https://www.nature.com/articles/s41598-021-95124-1

https://www.lupop.lu.se/article/reliability-self-reported-questionnaire-epidemiological-investigation-helicobacter-pylori - 2025-10-01

Validity of an algorithm to identify cardiovascular deaths from administrative health records: a multi-database population-based cohort study

A cardiovascular mortality algorithm applied to administrative health records had moderate validity when compared to vital statistics data. Substantial variation existed across study sites representing different geographic locations and two healthcare systems. These variations may reflect different diagnostic coding practices and healthcare utilization patterns. Read the paper at https://bmchealth

https://www.lupop.lu.se/article/validity-algorithm-identify-cardiovascular-deaths-administrative-health-records-multi-database - 2025-10-01

Reflection on modern methods: building causal evidence within high-dimensional molecular epidemiological studies of moderate size

This commentary provides a practical perspective on epidemiological analysis within a single high-dimensional study of moderate size to consider a causal question. Read the paper at https://academic.oup.com/ije/article/50/3/1016/6140018

https://www.lupop.lu.se/article/reflection-modern-methods-building-causal-evidence-within-high-dimensional-molecular-epidemiological - 2025-10-01

Future of surgical registries

The value of accurate healthcare data has never been more apparent than during the past year, and there is increasing recognition of the important role surgical registries play in driving improved patient outcomes, patient safety, and academic research. Successful registries need to be responsive and adapt to the rapidly changing clinical environment. Read the paper at https://academic.oup.com/bjs

https://www.lupop.lu.se/article/future-surgical-registries - 2025-10-01

Reflection on modern methods: causal inference considerations for heterogeneous disease etiology

Molecular pathological epidemiology research provides information about pathogenic mechanisms. A common study goal is to evaluate whether the effects of risk factors on disease incidence vary between different disease subtypes. Read the paper at https://academic.oup.com/ije/article/50/3/1030/6114706

https://www.lupop.lu.se/article/reflection-modern-methods-causal-inference-considerations-heterogeneous-disease-etiology - 2025-10-01