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The analysis of annual extremes of hydrological and meteorological variables is frequently complicated by the presence of gaps in record, and when records are not only fragmented but also short, it is necessary to utilize to the full the information contained in them. One method is to abstract for statistical analysis all extreme events whose peaks exceed a pre-selected threshold value, but the th

Popular Abstract in Swedish Under de senaste decennierna har matematisk modellering av finansiella marknader rönt stor uppmärksamhet både inom akademi och inom industri. Ett område som har visats särskilt intresse är prissättning av finansiella instrument så som optioner. En europeisk köpoption på en underliggande aktie är ett kontrakt som ger innehavaren rätten att vid en förutbestämt tidpunkt, The first part of this thesis deals with approximations of stochastic integrals and discrete time hedging of derivative contracts; two closely related subjects. Paper A considers the problem of approximating the value of a Wiener process. The discretization points are placed at times when the absolute difference between the value of the process and the approximation reaches a threshold level. It i

Systemic lupus erythematosus (SLE) is an autoimmune connective tissue disease that can affect the central nervous system. Neuropsychiatric symptoms are found in 25-70% of patients. Using diffusion tensor imaging (DTI) various studies have reported changes in white matter integrity in SLE patients with neuropsychiatric symptoms (NPSLE patients). The purpose of this study was to investigate, if regi

The prevalence of troublesome fear of childbirth (FOC) in Western countries is about 20%, of which approximately 6-10% suffer from severe FOC that impacts daily life. The countries of Sweden and Denmark are quite alike as far as childbirth culture is concerned. However, to some extent they differ in the organisation of midwifery care during the antenatal and labour period, respectively, and this m

The problem of fitting models to measured data has been studied extensively, not least in the field of computer vision. A central problem in this field is the difficulty in reliably find corresponding structures and points in different images, resulting in outlier data. This thesis presents theoretical results improving the understanding of the connection between model parameter estimation and pos

Popular Abstract in Swedish Autoimmuna sjukdomar, såsom typ 1 diabetes, uppstår till följd av en obalans i immunsystemet där immunceller ser kroppens egna vävnader som ett hot och angriper dem. Vid typ 1 diabetes är det de insulin-producerande β-cellerna i bukspottskörteln som förstörs, vilket leder till att man resten av livet får tillföra kroppen insulin genom injektioner. Anledningen till varföAutoimmunity, such as type 1 diabetes (T1D), arises as a result of tolerance breakdown against host tissues, i.e. the β-cells. Central tolerance is established during thymic T cell development and defects in key events during this process could contribute to the pathogenesis of autoimmune diseases. The work presented in this thesis was aiming at unravelling some of those aspects. We have investi

Microscopic diffusion anisotropy in porous materials can be quantified from diffusion NMR data acquired with a combination of directional and isotropic diffusion encoding. A drawback with current pulses sequences for isotropic encoding is that they all rely on spin echo sequences, which are only applicable to pore liquids with long transverse relaxation times and porous materials with negligible i

Magnetomotive ultrasound imaging is an emerging technique where superparamagnetic iron oxide nanoparticles can be used as an ultrasound contrast agent. A time-varying external magnetic field acts to move tissue embedded particles, and ultrasound is used to detect the resulting tissue movement. In experimental phantom studies we have observed a phase lag dispersion in the magnetomotive response in

Recension av Svetlana Aleksijevitj, Kriget har inget kvinnligt ansikte. En utopis röster.

Ankylosing spondylitis (AS) is associated with several extra-articular manifestations. Nephrolithiasis (NL) has not been recognized as one of those, however, several factors known to increase the risk of NL are at play in AS patients. The objective was to estimate rates and predictors of NL in Swedish patients with AS compared to the general population.

Pathological conditions affect several stages of neurogenesis in the adult brain, including proliferation, survival, cell fate, migration, and functional integration. Here we explored how a pathological environment modulates the heterogeneous afferent synaptic input that shapes the functional properties of newly formed neurons. We analyzed the expression of adhesion molecules and other synaptic pr

Stands of pedunculate oak (Quercus robur) planted 50-80 years ago on two types of land (previously forested land and former arable fields) were compared regarding vegetation and soil. Former arable soils were characterized by a higher pH, higher nitrate concentration and higher soil density, but had lower organic matter content and lower ammonium concentration in the topsoil (0-5 cm). These differ

This study reports increasing iron concentrations in rivers draining into the Baltic Sea. Given the decisive role of iron to the structure and biogeochemical function of aquatic ecosystems, this trend is likely one with far reaching consequences to the receiving system. What those consequences may be depends on the fate of the iron in estuarine mixing. We here assess the stability of riverine iron

A search for the associated production of the Higgs boson with a top quark pair is performed in multilepton final states using 20.3 fb(-1) of proton-proton collision data recorded by the ATLAS experiment at root s = 8 TeVat the Large Hadron Collider. Five final states, targeting the decays H -> WW*, tau tau, and ZZ*, are examined for the presence of the Standard Model (SM) Higgs boson: two same-ch

With special reference to India and Indonesia the paper considers a number of methodological issues connected with the study of corruption. These include definitions of corruption, a public administration approach, the bazaar concept vs questions of family, network, and patronage, limitations to corruption, and the political impact.

von Willebrand disease (VWD) is the most common inherited bleeding disorder characterized by spontaneous or tissue injury related, mostly mucocutaneous, bleeding events. VWD affects both males and females and is caused by quantitative or qualitative deficiency of von Willebrand factor. The diagnostic procedure is complicated because VWD is highly heterogeneous, and differential diagnosis from plat

MicroRNAs (miRNAs) are key players in the regulation of neuronal processes by targeting a large network of target messenger RNAs (mRNAs). However, the identity and function of mRNAs targeted by miRNAs in specific cells of the brain are largely unknown. Here, we established an adeno-associated viral vector (AAV)-based neuron-specific Argonaute2:GFP-RNA immunoprecipitation followed by high-throughpu

The ease with which Zebra Finches can be kept and bred in captivity makes them a suitable model for avian quantitative genetic studies. After a brief introduction to some quantitative genetic concepts, we here provide an up-to-date overview of quantitative genetic studies in Zebra Finches. We discuss what these studies can teach us about the evolutionary and behavioural ecology of Zebra Finches an

Locally advanced inextirpable gastrointestinal cancer has poor prognosis and is associated with high morbidity. One treatment option is to use radiotherapy, often combined with chemotherapy (chemoradiation), either as preoperative treatment to facilitate surgery or in the palliative setting to relieve symptoms. The aim of this thesis was to investigate efficacy and toxicity of intensive chemoradia