Single-Cell Profiling of Coding and Noncoding Genes in Human Dopamine Neuron Differentiation cells Article Single-Cell Profiling of Coding and Noncoding Genes in Human Dopamine Neuron Differentiation Fredrik Nilsson, Petter Storm, Edoardo Sozzi, David Hidalgo Gil, Marcella Birtele, Yogita Sharma, Malin Parmar * and Alessandro Fiorenzano * Citation: Nilsson, F.; Storm, P.; Sozzi, E.; Hidalgo Gil,

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Towards stem cell based therapies for Parkinson's disease SPOTLIGHT Towards stem cell based therapies for Parkinson’s disease Malin Parmar* ABSTRACT Treating neurodegenerative diseases with cell transplantation has been within reach since the first pioneering clinical trials in which dopamine neuron progenitors from the fetal brain were transplanted to individuals with Parkinson’s disease. However

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Generating regionalized neuronal cells from pluripotency, a step-by-step protocol METHODS ARTICLE published: 03 January 2013 doi: 10.3389/fncel.2012.00064 Generating regionalized neuronal cells from pluripotency, a step-by-step protocol Agnete Kirkeby*, Jenny Nelander and Malin Parmar Department of Experimental Medical Science and Lund Stem Cell Center, Lund University, Lund, Sweden Edited by: Cla

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Dopamine neuron precursors within the developing human mesencephalon show radial glial characteristics Dopamine Neuron Precursors Within the Developing Human Mesencephalon Show Radial Glial Characteristics JOSEPHINE B. HEBSGAARD,1,2 JENNY NELANDER,1,2 HANNA SABELSTR€OM,3 MARIE E. J€ONSSON,1,2 SIMON STOTT,4 AND MALIN PARMAR1,2* 1Department of Experimental Medical Science, Wallenberg Neuroscience Ce

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REV_ISS_WEB_jnc_6650_113-4 836..847 *MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, London, UK Wallenberg Neuroscience Centre, Lund University, Lund, Sweden The midbrain dopaminergic (mDA) neurons are the largest assembly of dopaminergic neurons in the central nervous system and play an important role in motor control, reward, addiction and cognition (Bjorklund and Lindvall 1

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Regional Specification of Neurosphere Cultures Derived from Subregions of the Embryonic Telencephalon Regional Specification of Neurosphere Cultures Derived from Subregions of the Embryonic Telencephalon M alin P arm ar,1 C harlotta S kogh, And ers Björklund , and K enneth C a m p b ell2 Wallenberg Neuroscience Center, Division of Neurobiology, Lund University, Solvegatan 17, BMC A11, S-221 84 Lu

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doi:10.1016/S1044-7431(03)00239-2 Phenotypic and molecular identity of cells in the adult subventricular zone: in vivo and after expansion in vitro Malin Parmar,a,* Andreas Sjöberg,b Anders Björklund,a and Zaal Kokaiab a Wallenberg Neuroscience Center, Division of Neurobiology, Lund University, BMC A11, SE-221 84 Lund, Sweden b Laboratory of Neural Stem Cell Biology, Section of Restorative Neuro

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Cell-based therapies for Parkinson disease—past insights and future potential NATURE REVIEWS | NEUROLOGY ADVANCE ONLINE PUBLICATION | 1 John van Geest Centre for Brain Repair & Department of Neurology, Department of Clinical Neurosciences, University of Cambridge, Forvie Site, Cambridge CB2 0PY, UK (R.A.B.). Wallenberg Neuroscience Center, Division of Neurobiology and Lund Stem Cell Center, Lund U

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Single cell transcriptomics identifies stem cell-derived graft composition in a model of Parkinson’s disease ARTICLE Single cell transcriptomics identifies stem cell-derived graft composition in a model of Parkinson’s disease Katarína Tiklová1,2,6, Sara Nolbrant 3,6, Alessandro Fiorenzano3,6, Åsa K. Björklund 4, Yogita Sharma3, Andreas Heuer 3, Linda Gillberg1,2, Deirdre B. Hoban3, Tiago Cardoso

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Generation of high-purity human ventral midbrain dopaminergic progenitors for in vitro maturation and intracerebral transplantation © 2 01 7 N at u re A m er ic a, In c. , p ar t o f S p ri n g er N at u re . A ll ri g h ts r es er ve d . © 2 01 7 N at u re A m er ic a, In c. , p ar t o f S p ri n g er N at u re . A ll ri g h ts r es er ve d . © 2017 Macmillan Publishers Limited, part of Springer

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untitled Human foetal brain tissue as quality control when developing stem cells towards cell replacement therapy for neurological diseases Jenny Nelander, Shane Grealish and Malin Parmar Human foetal brain tissue has been used in experimental and clinical trials to develop cell replacement therapy in neurodegenerative disorders such as Parkinson’s disease and Huntington’s disease. These pioneerin

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A systematic capsid evolution approach performed in vivo for the design of AAV vectors with tailored properties and tropism A systematic capsid evolution approach performed in vivo for the design of AAV vectors with tailored properties and tropism Marcus Davidssona,1, Gang Wanga,1,2, Patrick Aldrin-Kirka, Tiago Cardosob, Sara Nolbrantb, Morgan Hartnora, Janitha Mudannayakea, Malin Parmarb, and Tom

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Activity in grafted human iPS cell–derived cortical neurons integrated in stroke-injured rat brain regulates motor behavior Activity in grafted human iPS cell–derived cortical neurons integrated in stroke-injured rat brain regulates motor behavior Sara Palma-Tortosaa,1, Daniel Torneroa,b,1 , Marita Grønning Hansena, Emanuela Monnia, Mazin Hajya, Sopiko Kartsivadzea,c, Sibel Aktaya, Oleg Tsupykov

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Comparability: manufacturing, characterization and controls, report of a UK Regenerative Medicine Platform Pluripotent Stem Cell Platform Workshop, Trinity Hall, Cambridge, 14–15 September 2015 483Regen. Med. (2016) 11(5), 483–492 ISSN 1746-0751 part of Comparability: manufacturing, characterization and controls, report of a UK Regenerative Medicine Platform Pluripotent Stem Cell Platform Workshop

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Small molecules increase direct neural conversion of human fibroblasts 1Scientific RepoRts | 6:38290 | DOI: 10.1038/srep38290 www.nature.com/scientificreports Small molecules increase direct neural conversion of human fibroblasts Ulrich Pfisterer1,2, Fredrik Ek3, Stefan Lang2,4, Shamit Soneji2,4, Roger Olsson3 & Malin Parmar1,2 The generation of human induced neurons (hiNs) via exogenous delivery

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untitled Highly efficient generation of induced neurons from human fibroblasts that survive transplantation into the adult rat brain Maria Pereira, Ulrich Pfisterer, Daniella Rylander, Olof Torper, Shong Lau, Martin Lundblad, Shane Grealish & Malin Parmar Department of Experimental Medical Science, Wallenberg Neuroscience Center and Lund Stem Cell Center, Lund University, 221 84 Lund, Sweden. Indu

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