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Background: Early evidence suggests beta-blockers may have a disease-modifying effect in hereditary haemorrhagic telangiectasia (HHT). We aimed to assess the efficacy of oral propranolol is reducing severity of HHT-related epistaxis. Methods: A randomised, double blind, placebo controlled clinical trial was conducted in adults with HHT experiencing epistaxis. Subjects were randomly assigned to rec

Background and Aims. While the rationale for coronavirus disease 2019 (COVID-19) vaccination is to reduce complications and overall mortality, some cardiovascular complications from the vaccine itself have been demonstrated. Myocarditis and pericarditis are recognized as rare acute adverse events after mRNA vaccines in young males, while evidence regarding other cardiovascular events remains limit

In multiple myeloma (MM), advancements in treatments and toxicity management have enhanced survival rates. This, coupled with shifting age demographics in MM, necessitates an updated assessment of infection risks in MM patients compared to the general population. Using Swedish population-based registries, we investigated the incidence of infections in 8,672 Swedish symptomatic MM patients diagnose

Soil management is a crucial aspect of sustainable agriculture, and traditional knowledge has played a pivotal role in shaping practices that maintain soil health over time. This study examines the significance of traditional soil management techniques used in Uttar Pradesh, India, and assesses their effectiveness in addressing modern agricultural challenges. The primary objective of this analysis

We study the possibility of designing No(1)-round protocols for problems of substantially super-linear polynomial-time (sequential) complexity on the congested clique with about N1/2 nodes, where N is the input size. We show that the average time complexity of the local computation performed at a clique node (in terms of the size of the data received by the node) in such protocols has to be substa

Background. Treatment of childhood medulloblastoma has evolved to reduce neurotoxicity while improving survival. However, the impact of evolving therapies on late neurocognitive outcomes and adult functional independence remains unknown. Methods. Adult survivors of childhood medulloblastoma (n = 505; median [minimum–maximum] age, 29 [18–46] years) and sibling controls (n = 727; 32 [18–58] years) f

Many companies leverage the creativity of their employees to gather ideas for innovations. These ideas are collected, saved, and evaluated via platforms known as corporate ideation systems. Moderated ideation systems (ideation 2.0) emerged as a solution to address the limitations of traditional, rather passive ideation systems (ideation 1.0). In this study, we apply a qualitative mixed-method appr

Heart and lung transplantation remain the primary treatments for end-stage organ failure; yet organ shortages and ischemia-reperfusion injury (IRI) limit their success. Extended criteria donors (ECDs) have expanded the donor pool; however, prolonged cold ischemia times increase the risk of primary graft dysfunction (PGD). Static cold storage (SCS), the standard organ preservation method, is subopt

Embodiment has slowly been integrated as a category of analysis in (critical) military studies. In this article, we argue that embodiment–and related concepts such as body, affects and emotions–has become prevalent concerns over the 10-year consolidation of the intellectual project of the journal CMS. We propose an inquiry organized around three axes: situating current debates in the broader field

Cyanobacteria are bioactive compounds that produce toxins known as harmful algal blooms, posing serious threats to humans and marine life. Consequently, developing a robust monitoring framework to track and forecast the growth of such blooms is critical. The present work aims to understand the key environmental drivers influencing cyanobacterial bloom dynamics along the Southeast coast of India us

Objectives: To analyze device designs, similarities and overlaps of custom-made fenestrated arch endografts intended for mid/distal arch thoracic endovascular aortic repair. Materials and Methods: A multicenter cross-sectional study analyzing custom-made anonymized graft plans was performed. Graft plans were included from a cohort of mid/distal aortic arch repairs using custom-made fenestrated aor

Background and aims: Gallstone disease during pregnancy can have varying consequences, from mild to severe and even life-threatening. The aim was to investigate how gallstone intervention during pregnancy impacts pregnancy, delivery and the newborn child. Methods: Pregnant patients 18–45 years identified from the Swedish National Register for Gallstone Surgery and Endoscopic Retrograde Cholangiopa

Brain amyloid-β (Aβ) pathology is a core feature of Alzheimer disease (AD) and can be quantified using positron emission tomography (PET). Cerebrospinal fluid (CSF) and plasma biomarkers detect abnormal Aβ, but it is unclear to what degree they can predict quantitative Aβ-PET. We explored plasma and CSF biomarkers in relation to Aβ-PET in the BioFINDER-2 study (N = 1053), and the BioFINDER-1 study

Objective: Synovial fluid contains proteins that may have been released from surrounding tissues, our aim was to gain new insights into the proteomic profiles of human synovial fluid in knees with and without osteoarthritis (OA). Methods: We used synovial fluid from 11 patients with end-stage medial compartment knee OA, aspirated during total knee replacement, and from 13 deceased donors who had n

Objective: To evaluate the effects of excluding fatty tissue in QSM of human knee cartilage. Materials and methods: Gradient echo images from 18 knee-healthy volunteers were acquired, from which chemical shift corrected field perturbation maps were calculated. Based on these, QSM maps were reconstructed using morphology enabled dipole inversion and one of three masking alternatives: (1) excluding

Background: Low adherence to lipid-lowering therapy (LLT) after myocardial infarction (MI) is associated with increased risk of recurrent cardiovascular events and death. However, little is known about long-term adherence patterns following treatment interruptions. The aim of this study was to describe adherence trajectories in MI patients following a LLT treatment gap, and model the impact of dif

Organoid systems hold promise as miniaturized in vitro platforms that model developmental and pathological processes. However, the engineering of human bone marrow organoids (BMOs) has been a long-standing challenge. Recently, the field has witnessed the emergence of BMO-like systems, a potential paradigm shift for the study of human hematopoiesis and associated niche elements. Published protocols

Background: Continuity of care (CoC) is essential for effective primary health care (PHC), yet Swedish PHC has historically exhibited low levels of continuity. The Swedish Patient Choice Reform introduced privatization and market-oriented principles into PHC, leading to increased utilization and growing inequities in service use driven by socioeconomic disparities and misalignment with health care