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Molecular subtyping of pulmonary large-cell neuroendocrine carcinoma (LCNEC) based on retinoblastoma protein (pRb) expression may influence systemic treatment decisions. Current histomorphologic assessments of hematoxylin and eosin–stained tissue samples cannot reliably differentiate LCNEC molecular subtypes. This study explores the potential of deep learning (DL) to identify histologic patterns t

With 23,000 registered participants and unprecedented media attention, the 16th conference of the parties (COP) to the United Nations Convention on Biological Diversity (CBD) in Cali, Colombia, was the largest in the 32-year history of these biannual meetings. In terms of successes, the Cali conference established a new subsidiary body to protect concerns of indigenous communities and local popula

The influence of alkyl chain on the physical and photochemical properties of D-A-π-A-π-A sensitizers (GZ-121 and GZ-124) for dye-sensitized solar cells (DSSCs) was investigated through density functional theory (DFT). Key aspects examined include geometry, optical characteristic, electron injection, intramolecular charge transfer, and dye regeneration. Adsorption models of dye@TiO2, short-circuit

Phlorotannins, the polyphenols mostly found in brown seaweeds, have attracted high attention from the pharmaceutical industry in recent years due to their antioxidant, antibacterial, and anti-inflammatory activities. These properties make them desirable to be utilized in a wide range of therapeutics. Despite their importance, several challenges make their extractability and identification complex,

Organizations may be confronted with both expected and unexpected events that challenge their abilities to provide these services uninterrupted. Traditional strategies based on anticipation and planning are primarily useful for expected events, but for unexpected events, organizations must develop capacities to adapt to situations and conditions not foreseen. As systems and societies are becoming

The process of industrialization is typically associated with urbanization and a large urban-rural gap in productivity and skills. To what extent were these disparities driven by the direct impact on occupational attainment of living in an urban area or the result of the positive self-selection of migrants moving to cities? In this paper, we leverage exceptional Swedish longitudinal data that allo

In this contribution we present the preliminary results regarding laser-driven nuclear isomer-production obtained during the commissioning of 1 PW-E7 experimental area at ELI-NP. The study of nuclear isomers production and their photoreactions has been a subject of lasting interest in the nuclear physics community. Nuclear isomers play a crucial role in the creation of the elements in the Universe

Swedish multifamily housing is dominated by warm-rent apartments, where heating is included in the rent. This, together with low inequality and an extensive social security system, has been argued to protect a large part of the Swedish population from energy poverty. However, during the energy crisis of 2021–2023, energy poverty quickly rose on the public agenda. In this paper, we challenge the do

Background: Substance use disorder (SUD) is associated with elevated suicide risk. The aim was to compare health care contacts as well as clinical and suicide-specific characteristics in individuals with and without substance use issues who died by suicide. Methods: Data were derived from a nationwide medical record review of confirmed suicides in Sweden. In the current study we included individua

This paper reviews the state of knowledge on past and present storms and marine coastal flooding (MCF) events of various origins within the Baltic Sea, which is an economically and environmentally important part of northwestern Europe. We show that the combination of sedimentary, historical and instrumental records provides the most comprehensive insight into the history of storms and MCF. The fre

Massively parallel sequencing (MPS) is increasingly used in forensic DNA analysis for SNP and STR genotyping, though accredited proficiency tests remain limited. To address this, five forensic DNA laboratories from four countries participated in a study to assess MPS methods across different kits and platforms. In this study ForenSeq DNA Signature Prep Kit, ForenSeq MainstAY kit, Precision ID Glob

Miniaturisation can influence the foraging behaviour of flower visitors by shaping their sensory systems, flight capabilities, and their compatibility with floral shapes and structures. For bees, vision is a primary sensory modality, and a reduction in eye size compromises the resolution and sensitivity of vision. In Tetragonula iridipennis, a diminutive tropical stingless bee common in South Asia

Aims: To examine how educational attainment impacts clinical presentation and pharmacological treatment at type 2 diabetes (T2D) diagnosis. Methods: Cross-sectional analysis of 10,020 individuals with recently diagnosed T2D enrolled in the Danish prospective DD2 cohort. Sex- and age-adjusted prevalence ratios (aPRs) for detailed clinical characteristics and pharmacotherapy were computed. Results:

Introduction: Traditional cardiovascular risk factors put patients with congenital heart disease (CHD) at increased risk for acquired cardiovascular disease and mortality – more so than patients without CHD. In the general population, health related quality of life (HRQoL) is associated with regular physical activity. It was the aim of this study to evaluate the most important predictors of HRQoL

Aim: To qualitatively assess an intervention for ambulance nurses, including simulation training concerning intimate partner violence (IPV), and to describe the ambulance nurses’ experiences of their work after the intervention. Background: IPV is a common public health issue with serious consequences from individual and societal perspectives. Previous research indicates that deficits in knowledge

Trauma accounts for around 4.4 million deaths annually and is among the leading causes of death, disproportionately affecting low- and middle-income countries. Trauma quality improvement programmes may reduce adverse patient outcomes but lack robust evidence. This study assessed the effect of implementing a trauma quality improvement programme using audit filters on health-related quality of life

Small neutral organic compounds have traditionally the role of EOF markers in electrophoresis, as they are expected to have zero electrophoretic mobility in external electric fields. The BGE contains, however, ions that have unequal affinities to the neutral molecules, which in turn results in their mobilization. In this study we focused on two EOF markers-thiourea and DMSO, as well as on N-methyl

Release of halide ions is an essential step of the catalytic cycle of haloalkane dehalogenases. Here we describe experimentally and computationally the process of release of a halide anion from the buried active site of the haloalkane dehalogenase LinB. Using stopped-flow fluorescence analysis and umbrella sampling free energy calculations, we show that the anion binding is ion-specific and follow

Neutron diffraction with isotopic substitution was performed on aqueous solutions of isopropyl alcohol and isopropylamine. The difference between these two measurements primarily contains information about the different hydration of the alcohol and amino group. This data is used as a test of the accuracy of molecular dynamic simulations of the same systems. Having established the level of accuracy