Background: Hypertension is the leading risk factor for cerebral small vessel disease. We aimed to determine whether antihypertensive drug classes differentially affect microvascular function in people with small vessel disease. Methods: We did a multicentre, open-label, randomised crossover trial with blinded endpoint assessment at five specialist centres in Europe. We included participants aged

Autoimmune regulator (AIRE) is a transcriptional regulator expressed in the thymus and necessary for maintaining immunological self-tolerance. Extra-thymic AIRE expression is rare and a role for AIRE in tumor-associated innate immune cells has not yet been established. In this study we show that AIRE is expressed in human pro-tumor neutrophils. In breast cancer, AIRE was primarily located to tumor

An animal's visual field is the three-dimensional space around its head from which it can extract visual information at any instant1. Bird visual fields vary markedly between species, and this variation is likely to be driven primarily by foraging ecology1,2,3. The binocular visual field is the region in which the visual fields of the two eyes overlap; thus, objects in the binocular field are imag

We investigate the formation of self-bound quantum droplets in a one-dimensional binary mixture of bosonic atoms, applying the method of numerical diagonalization of the full Hamiltonian. The excitation spectra and ground-state pair correlations signal the formation of a few-boson droplet when crossing the region of critical interspecies interactions. The self-binding affects the rotational excita

This research contributes to the Management of Technology (MOT) literature by scrutinizing the interrelation between education, experience, and the scaling aptitudes of high-tech companies. The study hinges on a comprehensive analysis of data collected from 1987 C-level executives and 3644 born-digital firms that pursued funding via blockchain-based Initial Coin Offerings (ICOs). Employing structu

The rapid development of containerization technology comes with remarkable benefits for developers and operation teams. Container solutions allow building very flexible software infrastructures. Although lots of efforts have been devoted to enhancing containerization security, containerized environments still have a huge attack surface. Completely avoiding severe security issues have so far not be

En systematisk litteraturgenomgång gjordes avseende effekterna av vägunderhåll och reparationsarbeten på cyklister. Fynden visar att befintliga svenska riktlinjer är otydliga och inte tillräckligt tar hänsyn till cyklisters förutsättningar och behov. Det finns inte heller några tydliga exempel på hur cyklister ska hanteras i praktiken. Det finns ett tydligt behov av att utveckla tydliga standarder

Background: Early detection of treatment response is important for the management of patients with malignant brain tumors such as glioblastoma to assure good quality of life in relation to therapeutic efficacy. Aim: To investigate whether parametric response mapping (PRM) with diffusion MRI may provide prognostic information at an early stage of standard therapy for glioblastoma. Materials and met

Taking its cue from questions raised in ecocritical theory, this article studies some of the central themes in the poetry of Swedish ALMA laureate Barbro Lindgren: the non-hierarchical attitude towards all that lives and exists; the cycle of life and death that is a fundamental condition of existence for human and non-human animals as well as for trees and plants; and the exploration of scales tha

Hösten 2024 är det 50 år sedan Carl-Göran Heidegren påbörjade sin akademiska bana i Lund. Med tanke på detta är det tur att en grupp sociologer med bakgrund på Sociologen i Lund redan år 2021 kom på tanken att uppmärksamma Carl-Göran och hans verk, med anledning av hans då förestående emeritering. I valet mellan att göra en festskrift eller en ’vanlig’ antologi tillsammans bestämde vi oss för att

Det som är störande för cyklister som passerar ett vägarbete är ojämnheter, omledning, bristfällig information från väghållaren, skyltning och oavskilda cykelvägar. Kvaliteten på omledningar och avstängningar är avgörande för att cyklister ska använda dem. Det behövs bättre omläggningar som inte utsätter cyklister för onödigt stora omvägar eller drastiskt minskade möjligheter att cykla förbi vägar

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Diabetes is a highly heterogeneous condition; yet, it is diagnosed by measuring a single blood-borne metabolite, glucose, irrespective of aetiology. Although pragmatically helpful, disease classification can become complex and limit advances in research and medical care. Here, we describe diabetes heterogeneity, highlighting recent approaches that could facilitate management by integrating three d

This paper examines how the significant events and team member trust in new ventures affect exit from the team. We consider team member exit as an outcome that affects both individuals, the team, and the performance of the new venture. We develop our arguments based on event system theory, which is specifically beneficial to understand how new ventures develop. We test our arguments using a unique

This chapter deals with children's participation in research concerning children's experience of exposure to violence, abuse or neglect and how ethical aspects of such research are regulated in Sweden. The Act (2003:460) on ethical review of research involving humans (etikprövningslagen, EPL), introduced in 2003, states that certain types of research require permission to be carried out. Since the