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Pyridoxal 5′-phosphate (PLP), the biologically active form of vitamin B6, is an essential cofactor in many biosynthetic pathways. The emergence of PLP-dependent enzymes as drug targets and biocatalysts, such as tryptophan synthase (TS), has underlined the demand to understand PLP-dependent catalysis and reaction specificity. The ability of neutron diffraction to resolve the positions of hydrogen a

The introduction of atomic layer deposition (ALD), to the microelectronics industry has introduced a large number of new possible materials able to be deposited in layers with atomic thickness control. One such material is the high-κ oxide HfO2; thermally stable and ultrathin HfO2 films deposited by ALD are a significant contender to replace SiO2 as the gate oxide in capacitor applications. We pre

With the aim to bridge the pressure gap between traditional surface science and industrial applications, heterogeneous catalytic reactions on model catalysts are increasingly studied at near-ambient pressures. Under those conditions, the gas phase has been shown to play an important role during the interaction at the gas-surface interface making it complex to study. This complexity can be capturedWith the aim to bridge the pressure gap between traditional surface science and industrial applications, heterogeneous catalytic reactions on model catalysts are increasingly studied at near-ambient pressures. Under those conditions, the gas phase has been shown to play an important role during the interaction at the gas-surface interface making it complex to study. This complexity can be captured

A chemical proteomics approach using Ca2+/calmodulin-dependent protein kinase kinase (CaMKK) inhibitor–immobilized sepharose (TIM-063-Kinobeads) identified main targets such as CaMKKα/1 and β/2, and potential off-target kinases, including AP2-associated protein kinase 1 (AAK1), as TIM-063 interactants. Because TIM-063 interacted with the AAK1 catalytic domain and inhibited its enzymatic activity m

I Danmark reguleres det sociale område i høj grad af rammelovgivning, som uddelegerer myndighed, regulerer gennem formålsbeskrivelser og gør det muligt for såkaldte velfærdsprofessionelle at udøve skøn. Denne artikel undersøger, hvordan samspillet mellem velfærdsprofessionelles opfattelser og de ting, der på forskellig vis regulerer deres praksis, får betydning for konstruktionen af legalitet i de

Recent research on the relationship between grammatical aspect and motion event cognition has shown that speakers of nonaspect languages (e.g., German, Swedish) attend to event endpoints more than speakers of aspect languages (e.g., English, Spanish). In this study, we took a perceptual learning approach to the Whorfian hypothesis, training native English speakers to categorize events either in an

Studies show cross-linguistic differences in motion event encoding, such that English speakers preferentially encode manner of motion more than Spanish speakers, who preferentially encode path of motion. Focusing on native Spanish speaking children (aged 5;00–9;00) learning L2 English, we studied path and manner verb preferences during descriptions of motion stimuli, and tested the linguistic rela

In recent years, there has been a ‘crackdown’ against environmental defenders across Uganda. Journalists, students, farmers, and rural dwellers are defending the natural environment, protesting and mobilizing against unfair treatment and forced displacements brought by fossil fuel infrastructures, agribusiness, hydropower, or carbon offsetting. This has pitted authorities and large-scale capital a

I maj och juni 2014 genomförde institutionen för arkeologi och antik historia, Lunds universitet, en arkeologisk undersökning vid Kämpinge i Räng sn, Skåne. Undersökningen leddes av Jan Apel och föranleddes av de stora mängder lösfynd från som över åren gjorts inom fornlämningen RAÄ 4:1, Rängs sn. Totalt handgrävdes 22 m2 och 781 fyndposter registrerades. Utöver detta sonderades undersökningsområd

Acute lung injury (ALI) represents an aetiologically diverse form of pulmonary damage. Part of the assessment and diagnosis of ALI depends on skilled observer-based scoring of brightfield microscopy tissue sections. Although this readout is sufficient to determine gross alterations in tissue structure, its categorical scores lack the sensitivity to describe more subtle changes in lung morphology.

Introduction: The Coronavirus 2019 Disease (COVID-19) pandemic reached the Nordic countries in March 2020. Public health interventions to limit viral transmission varied across different countries both in timing and in magnitude. Interventions indicated by an Oxford Stringency Index ≥50 were implemented early (March 13–17, 2020) in Denmark, Finland, Norway and Iceland, and on March 26, 2020 in Swe

Denna europapolitiska analys handlar om den svenska förvaltningsmodellen och hur den fungerar i förhållande till EU-rättsliga krav på oberoende myndigheter. Bakgrunden är att EU:s sekundärrätt ibland kräver att nationella förvaltningsmyndigheter som genomför EU-rätten ska vara oberoende. De tydligaste kraven handlar om tillsynsmyndigheter för dataskydd i allmänna dataskyddsförordningen (GDPR).Den

Background: The assessment of serum neurofilament light chain (sNFL) has emerged as a diagnostic and prognostic tool in monitoring multiple sclerosis (MS). However, the application of periodic measurement in daily practice remains unclear. Objective: To evaluate the predictive value of individual sNFL levels in determining disease activity in patients with relapsing MS (RMS). Methods: In this two-