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A chemical proteomics approach using Ca2+/calmodulin-dependent protein kinase kinase (CaMKK) inhibitor–immobilized sepharose (TIM-063-Kinobeads) identified main targets such as CaMKKα/1 and β/2, and potential off-target kinases, including AP2-associated protein kinase 1 (AAK1), as TIM-063 interactants. Because TIM-063 interacted with the AAK1 catalytic domain and inhibited its enzymatic activity m
I Danmark reguleres det sociale område i høj grad af rammelovgivning, som uddelegerer myndighed, regulerer gennem formålsbeskrivelser og gør det muligt for såkaldte velfærdsprofessionelle at udøve skøn. Denne artikel undersøger, hvordan samspillet mellem velfærdsprofessionelles opfattelser og de ting, der på forskellig vis regulerer deres praksis, får betydning for konstruktionen af legalitet i de
Recent research on the relationship between grammatical aspect and motion event cognition has shown that speakers of nonaspect languages (e.g., German, Swedish) attend to event endpoints more than speakers of aspect languages (e.g., English, Spanish). In this study, we took a perceptual learning approach to the Whorfian hypothesis, training native English speakers to categorize events either in an
Studies show cross-linguistic differences in motion event encoding, such that English speakers preferentially encode manner of motion more than Spanish speakers, who preferentially encode path of motion. Focusing on native Spanish speaking children (aged 5;00–9;00) learning L2 English, we studied path and manner verb preferences during descriptions of motion stimuli, and tested the linguistic rela
In recent years, there has been a ‘crackdown’ against environmental defenders across Uganda. Journalists, students, farmers, and rural dwellers are defending the natural environment, protesting and mobilizing against unfair treatment and forced displacements brought by fossil fuel infrastructures, agribusiness, hydropower, or carbon offsetting. This has pitted authorities and large-scale capital a
I maj och juni 2014 genomförde institutionen för arkeologi och antik historia, Lunds universitet, en arkeologisk undersökning vid Kämpinge i Räng sn, Skåne. Undersökningen leddes av Jan Apel och föranleddes av de stora mängder lösfynd från som över åren gjorts inom fornlämningen RAÄ 4:1, Rängs sn. Totalt handgrävdes 22 m2 och 781 fyndposter registrerades. Utöver detta sonderades undersökningsområd
Acute lung injury (ALI) represents an aetiologically diverse form of pulmonary damage. Part of the assessment and diagnosis of ALI depends on skilled observer-based scoring of brightfield microscopy tissue sections. Although this readout is sufficient to determine gross alterations in tissue structure, its categorical scores lack the sensitivity to describe more subtle changes in lung morphology.
Introduction: The Coronavirus 2019 Disease (COVID-19) pandemic reached the Nordic countries in March 2020. Public health interventions to limit viral transmission varied across different countries both in timing and in magnitude. Interventions indicated by an Oxford Stringency Index ≥50 were implemented early (March 13–17, 2020) in Denmark, Finland, Norway and Iceland, and on March 26, 2020 in Swe
Denna europapolitiska analys handlar om den svenska förvaltningsmodellen och hur den fungerar i förhållande till EU-rättsliga krav på oberoende myndigheter. Bakgrunden är att EU:s sekundärrätt ibland kräver att nationella förvaltningsmyndigheter som genomför EU-rätten ska vara oberoende. De tydligaste kraven handlar om tillsynsmyndigheter för dataskydd i allmänna dataskyddsförordningen (GDPR).Den
Background: The assessment of serum neurofilament light chain (sNFL) has emerged as a diagnostic and prognostic tool in monitoring multiple sclerosis (MS). However, the application of periodic measurement in daily practice remains unclear. Objective: To evaluate the predictive value of individual sNFL levels in determining disease activity in patients with relapsing MS (RMS). Methods: In this two-
Punch biopsies are commonly used in dermatology for diagnosing skin diseases. Traditional methods involve the use of forceps, skin hooks, and scissors, which add to health care costs. The technique described here offers a cost-effective and efficient alternative for obtaining specimens.
Sex education can impact pupils’ sexual activity and convey the social norms regarding family formation and responsibility, which can have significant consequences to their future. To investigate the life-cycle effects of social norm transmission, this study draws on the introduction of comprehensive sex education in the curriculum of Swedish primary schools during the 1940s to the 1950s. Inspired
This thesis investigates the question ‘What is knowledge?’ In intuition-based epistemology the question is often considered to concern how ‘knowledge’ is used linguistically or conceptually rather than what knowledge is. In addition, since intuitions are used as evidence despite empirical experiments indicating that people’s intuitions vary a great deal and that little conclusive systematicity can
