The conventional indirect immunofluorescence assay for islet cell antibodies was compared with a two-colour immunofluorescent assay to detect both islet cell antibodies with fluorescein isothiocyanate-labeled rabbit anti-human IgG and pancreatic B cells with a monoclonal human proinsulin antibody and Texas red-labeled sheep anti-mouse IgG. Determinations of end-point titres showed a correlation be

The transport and oxidation of glucose, the content of fructose 1,6-diphosphate, and the release of insulin were studied in microdissected pancreatic islets of ob/ob mice incubated in Krebs-Ringer bicarbonate medium. Under control conditions glucose oxidation and insulin release showed a similar dependence on glucose concentration with the steepest slope in the range 5-12mm. The omission of Ca(2+)

Den islamistiska regimen är upprörd över en svensk rättegång mot en tidigare tjänsteman för massmord, och en iransk dokumentär visar upp en kidnappad svensk-iranier i en propagandakampanj mot Sverige, skriver våra gästkrönikörer Arvin och Ardavan Khoshnood.The Islamic regime in Iran is outraged by a Swedish trial of a former mass murder official, and an Iranian documentary shows a kidnapped Swedish-Iranian in a propaganda campaign against Sweden, write our guest columnists Arvin and Ardavan Khoshnood.

Using multilayer zone plates (MZPs) as two-dimensional optics, focal spot sizes of less than 10 nm can be achieved, as we show here with a focus of 8.4 nm × 9.6 nm, but the need for order-sorting apertures prohibits practical working distances. To overcome this issue, here an off-axis illumination of a circular MZP is introduced to trade off between working distance and focal spot size. By this, t

The streaming instability provides an efficient way of overcoming the growth barriers in the initial stages of the planet formation process. Considering the realistic case of a particle size distribution, the dynamics of the system is altered compared to the outcome of single size models. In order to understand the outcome of the multispecies streaming instability in detail, we perform a large par

At least 30% of main sequence stars host planets with sizes of between 1 and 4 Earth radii and orbital periods of less than 100 days.We use N-body simulations including a model for gas-assisted pebble accretion and disk–planet tidal interaction to study the formation of super-Earth systems.We show that the integrated pebble mass reservoir creates a bifurcation between hot super-Earths or hot-Neptu

Here we discuss the current state of knowledge of terrestrial planet formation from the aspects of different planet formation models and isotopic data from 182Hf-182W, U-Pb, lithophile-siderophile elements, 48Ca/44Ca isotope samples from planetary building blocks, recent reproduction attempts from 36Ar/38Ar, 20Ne/22Ne, 36Ar/22Ne isotope ratios in Venus’ and Earth’s atmospheres, the expected solar

Solid particles in protoplanetary discs can grow by direct vapour deposition outside of ice lines. The presence of microscopic silicate particles may nevertheless hinder growth into large pebbles, since the available vapour is deposited predominantly on the small grains that dominate the total surface area. Experiments on heterogeneous ice nucleation, performed to understand ice clouds in the Mart

BACKGROUND: Streptococcus pneumoniae remains a major cause of community-acquired pneumonia, meningitis, and other diseases, contributing significantly to high morbidity and mortality worldwide. Although it responds to antibiotics, their use is becoming limited due to the rise in antibiotic resistance, which necessitates the development of new therapeutics. Nanotechnology is used to counteract anti

Background: Malignant Mesothelioma (MM), an orphan but aggressive malignancy of the mesothelial membrane, is a fatal tumor. Global epidemic related to malignant pleural mesothelioma is on the rise, so there is a need to explore novel biomarkers and ingenious therapeutic approaches to stalk this silent killer.Objective: The main aim of the present review is to provide a consolidated overview of the

Background: Rich in different kind of potent cells, embryos are used in modern regenerative medicine and research. Neurobiologists today are pushing the boundaries for what can be done with embryos existing in the transitory margins of medicine. Therefore, there is a growing need to develop conceptual frameworks for interpreting the trans‐ formative cultural, biological and technical processes inv

An interior building-archaeological investigation of parts of Glimmingehus castle has been conducted. One of the aims was to document the two large rooms, today called “the Banqueting Hall” and “the Archers’ Loft”. Another was to answer some questions about the original functions of the rooms. The two rooms are connected by a simple wooden staircase. One of the questions concerned the original loo

The present study suggests that the theoretical framework of evolutionary psychology, in particular theories and models relating to social status and pride, can be used to further our understanding of educational motivation. Our assumption was that the desire for social recognition and high status is a universal human phenomenon. Based on this, we suggested that differences in educational motivati

Water contamination with per- and polyfluoroalkyl substances (PFAS) is a serious problem for water suppliers in many regions. Due to persistence of the substances and a complex distribution mechanism, PFAS can have an adverse impact on water quality. Reported toxicological and health effects, make it very important to minimise the of wildlife and human exposure to PFAS. The exposure path is, howev

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