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OBJECTIVE—To assess the 12- and 52-week efficacy of the dipeptidyl peptidase IV inhibitor LAF237 versus placebo in patients with type 2 diabetes continuing metformin treatment. RESEARCH DESIGN AND METHODS—We conducted a 12-week, randomized, double-blind, placebo-controlled trial in 107 patients with type 2 diabetes with a 40-week extension in those completing the core study and agreeing, together

Subspecies of Trypanosoma brucei cause severe brain diseases after penetration of the blood-brain barrier. We investigated whether cytokines that modulate inflammatory cell infiltration into the brain also influence T. brucei neuroinvasion. Migration of a rodent pathogenic T. brucei strain from the cerebral blood vessels into the brain parenchyma was impeded in IFN-gamma(-/-), IFN-gamma receptor(-

Polarisation spectroscopy (PS) was used to probe CO2 gas concentration in a CO2/N-2 binary mixture at atmospheric pressure and ambient temperature. The CO2 molecules were probed by a direct laser excitation to an overtone and combination vibrational state. The tuneable narrow linewidth infrared laser radiation at 2 mum was obtained by Raman shifting of the output from a single-longitudinal-mode pu

Abstract is not available

Conversion and Confession – Religious Transitions similar to Conversion in Henric Schartau and F. G. Hedberg, related to a Second Confessional Age The nineteenth century has often been called an Age of Secularisation. This has been criticized as blindness of religion. The »long» nineteenth century meant a mobilization of religion. German Historian Olaf Blaschke has interpreted the period as a sec

Partial and complete injured median and ulnar nerves caused by fractures of the radius and ulna, respectively, in which the symptoms of nervous injury were induced at the time of fracture are reported. In cases with complete loss of nervous function early exploration should be considered at the time of reposition or plating of the fractured bones, or both, and in patients in whom nervous dysfuncti

Introduction. The information behaviour of a group of Swedish computer scientists has been studied over a period of 20 years (1987-2006). Changes in their information seeking are addressed in terms of collaboration levels and discussed as examples of social practice. Method. Qualitative interviewing has been the main method for data collection. Analysis. Interview transcripts have been content ana

The main purpose of this work is to study methods to simulate electro-thermal effects in integrated circuits using CONCISE a waveform relaxation based circuit simulator. WR is a method that is suitable to run on a multi-computer with state of the art computing power. Especially CMOS VLSI circuits have been simulated successfully with WR. With simulation experiments we have shown that

Popular Abstract in Swedish Denna rättssociologiska studie handlar om tvångsomhändertagna missbrukares rättssäkerhet under tiden i vård. Författaren undersöker begreppet rättssäkerhet i förhållande till tvångsvårdens verkställighet på så kallade LVM-hem i syfte att finna en begreppsdefinition som är operationaliserbar vid studier av rättssäkerhetens upprätthållande. Med utgångspunkt i resultaten Compulsory treatment and care is regulated by the Care of Alcoholics and Drug abusers Act (Lag (1988:870) om vård av missbrukare i vissa fall, LVM). The regulation's main purpose is to motivate persons with addictive problems to voluntarily participate in the treatment of their problems. The compulsory care shall continue for a maximum period of six months in special treatment centres (the so-call

We investigated possible physiological effects of the application of anti-browning substances on metabolically active potato tissues. The use of citric acid, ascorbic acid and L-cysteine for browning prevention of fresh-cut potatoes increased their metabolic heat production as measured by isothermal calorimetry. This effect was particularly high after treatment with L-cysteine, which also proved t

Three alleles at the PRKAG3 (RN) locus that influence the glycogen content of pork were found to be segregating in Hampshire x Landrace crossbred pigs, RN-, rn(+) as well as second mutant allele V 1991 (here denoted rn*). The effect of these three alleles on ultimate pH, pigment content, internal reflectance (FOP), surface colour measured by tristimulus colorimetry (L*, a*, b*) and fractions of de

Popular Abstract in Swedish Förbränningsmotor är i dagens värld den mest använda kraftkällan för fordon. Förbränningsmotorn har kontinuerligt utvecklats och förbättrats sedan Nicolaus August Ottos och Rudolf Diesels dagar, och kommer att fortsätta att utvecklas långt in i framtiden. Ingen konkurrerande teknik har ännu på allvar utmanat förbränningsmotorns ställning. Det finns en lång rad tänkbara The prime mover in the world today is the Internal Combustion (IC) engine. The development and improvement of the internal combustion engines since Nicolaus August Otto and Rudolf Diesel has continued until today and will continue long into the future. No major competitor to the IC engine has yet emerged. There is a long list of potential competitors but they still have to prove their superiority

Myosin light-chain phosphorylation is the primary mechanism for activating smooth-muscle contraction and occurs principally at Ser-19 of the 20 kDa light chains of myosin (LC(20)). In some circumstances, Thr-18 phosphorylation may also occur. Protein kinase C (PKC) can regulate LC(20) phosphorylation indirectly via signalling pathways leading to inhibition of myosin light-chain phosphatase. The go

Internal protein dynamics are intimately connected to enzymatic catalysis. However, enzyme motions linked to substrate turnover remain largely unknown. We have studied dynamics of an enzyme during catalysis at atomic resolution using nuclear magnetic resonance relaxation methods. During catalytic action of the enzyme cyclophilin A, we detect conformational fluctuations of the active site that occu