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As the scale of single-cell genomics experiments grows into the millions, the computational requirements to process this data are beyond the reach of many. Herein we present Scarf, a modularly designed Python package that seamlessly interoperates with other single-cell toolkits and allows for memory-efficient single-cell analysis of millions of cells on a laptop or low-cost devices like single-boa
Background: Obesity seems to be associated with a poorer response to adjuvant chemotherapy in breast cancer (BC); however, associations in the neoadjuvant chemotherapy (NACT) setting and according to menopausal status are less studied. This study aims to investigate the association between pretreatment body mass index (BMI) and pathological complete response (pCR) following NACT in BC according to
It has not been clarified whether the anti-atherosclerotic effect of lingonberry can be ascribed to its content of flavonoids or dietary fibre or both. The aim of this study was to evaluate the metabolic effects of whole lingonberries compared with isolated flavonoid and fibre fractions on atherosclerotic plaques, plasma lipid profiles, gut microbiota and microbiota-dependent metabolites in a
Software systems are increasingly depending on data, particularly with the rising use of machine learning, and developers are looking for new sources of data. Open Data Ecosystems (ODE) is an emerging concept for data sharing under public licenses in software ecosystems, similar to Open Source Software (OSS). It has certain similarities to Open Government Data (OGD), where public agencies share da
Monitoring a microservice system may bring a lot of benefits to development teams such as early detection of run-time errors and various performance anomalies. In this study, we explore deep learning (DL) solutions for detection of anomalous system's behavior based on collected monitoring data that consists of applications' and systems' performance metrics. The study is conducted in a collaboratio
This issue’s articles will offer views into the conditions of nation and nationalism from outside contemporary nationalism studies, or perhaps from a position that straddles the boundaries of the inside and outside of nationalism studies. We hope that they contribute in unexpected ways to focused research – sociological and beyond – on nationalism, and on nationalism’s and Christianity’s interlo
Movement patterns and habitat selection of animals have important implications for ecology and evolution. Darwin's finches are a classic model system for ecological and evolutionary studies, yet their spatial ecology remains poorly studied. We tagged and radio-tracked five (three females, two males) medium ground finches (Geospiza fortis) to examine the feasibility of telemetry for understanding t
Purpose: Radiomics entails the extraction of quantitative imaging biomarkers (or radiomics features) hypothesized to provide additional pathophysiological and/or clinical information compared to qualitative visual observation and interpretation. This retrospective study explores the variability of radiomics features extracted from images acquired with the 0.35 T scanner of an integrated MRI-Linac.
Aims/hypothesis: The aim of this study was to assess the interaction between genetic risk and lifestyle intervention on the occurrence of gestational diabetes mellitus (GDM) and postpartum diabetes. Methods: The RADIEL study is an RCT aimed at prevention of GDM and postpartum diabetes through lifestyle intervention. Participants with a BMI ≥30 kg/m2 and/or prior GDM were allocated to intervention
Background: The filaggrin gene (FLG) plays a role in skin diseases, with the skin barrier function being impaired in FLG null carriers. The role of FLG status in relation to nickel penetration into the skin remains unclear. Objectives: To elucidate the association between FLG status and nickel penetration into stratum corneum (SC) in individuals without self-reported history of nickel allergy. Met
This study presents a novel application of multivariate iterative learning control (ILC) to the continuous, chromatographic ion-exchange purification of biopharmaceuticals for consistent and reliable production. The ILC algorithm used was based on a linearized model of the retention times of two compounds as functions of the starting and ending values of a linear salt gradient. Simulations of an i
In order to simplify the hyperelastic characterisation of rubber materials, an extension of the standard hardness test is proposed. A number of indentation depths are chosen for the hardness test and the indentation forces for these depths are recorded. By this modification, hyperelastic constants can be derived from the test, providing more information from the test by a small extra effort. Equiv
Pulmonary arterial hypertension (PAH) is a rare disease with poor prognosis. The symptoms are often unspecific, which can lead to delayed diagnosis. Cardiac magnetic resonance imaging (CMR) can be used to accurately assess the right ventricle (RV) and is the gold standard for measuring volumes and global ventricular function, such as ejection fraction. However, even with preserved ejection fractio
Health care currently constitute one of the largest parts of the Scandinavian welfare system, with private as well as public providers competing on a quasi-market. In order to ensure an egalitarian and safe provision of health care services this sector is governed by several policies, laws and regulations. Previous research demonstrates that these services are regulated by processes of decommodifi
Amyloid peptide (AP) self-assembly is a hierarchical process. However, the mechanistic rule of guiding peptides to organize well-ordered nanostructure in a clear and precise manner remains poorly understood. Herein we explored the molecular insight of AP motif aggregates underlying hierarchical process with helical fibrillar structure by atomic force microscope, cryo-electron microscopy (cryo-EM),
