BACKGROUND: We recently showed that striatal overexpression of brain derived neurotrophic factor (BDNF) by adeno-associated viral (AAV) vector exacerbated L-DOPA-induced dyskinesia (LID) in 6-OHDA-lesioned rats. An extensive sprouting of striatal serotonergic terminals accompanied this effect, accounting for the increased susceptibility to LID.OBJECTIVE: We set to investigate whether the BDNF effe

The use of animal models in Parkinson's disease research has been controversial in terms of how well they relate to the clinical condition and thus their utility for translating therapies from the lab to the clinic. In this article, two researchers debate this issue with Roger Barker taking the view that such models are not useful and may even be misleading, while Anders Björklund defends their us

Advancing the concept of populism as a political style, this study compares the debate performances of two British party leaders, Nick Clegg and Nigel Farage, as they clashed in a pair of televised debates over Britain’s EU membership ahead of the2014 European Parliament elections. The argument tested is thatunder certain conditions, mainstream politicians will adopt a populist communicationstyle

The present study argues that political communication on social media is mediated by a platform’s digital architecture—the technical protocols that enable, constrain, and shape user behavior in a virtual space. A framework for understanding digital architectures is introduced, and four platforms (Facebook, Twitter, Instagram, and Snapchat) are compared along the typology. Using the 2016 U.S. elect

State-sponsored cyber groups have long utilized spear phishing to pierce government networks. Spear phishing relies on social engineering to trick individuals into revealing sensitive information or downloading malicious software, rather than hacking into a system vulnerability by force. While email remains the preferred medium to conduct spear phishing attacks, social media has opened up new atta

State-sponsored “bad actors” increasingly weaponize social media platforms to launch cyberattacks and disinformation campaigns during elections. Social media companies, due to their rapid growth and scale, struggle to prevent the weaponization of their platforms. This study conducts an automated spear phishing and disinformation campaign on Twitter ahead of the 2018 United States midterm elections

This study examines how politically themed computer games function as digital campaigning tools during elections. To make sense of this understudied phenomenon, the concept of political campaigning games (PCGs) is introduced and defined as advergames that promote a partisan political position in an electoral context. The study bridges theoretical literatures from game studies, media studies, and p

The novel coronavirus SARS-CoV-2 (COVID-19) has spread globally in a short period of time and quickly developed into a pandemic. In connection with its progress, entire cities and countries have been closed down, people are quarantined, and infrastructure and trade have been suspended. As this is a new virus, no vaccine or antiviral drugs are available, but instead non-medical measures such as soc

The recent rise of disinformation and propaganda on social media has attracted strong interest from social scientists. Research on the topic has repeatedly observed ideological asymmetries in disinformation content and reception, wherein conservatives are more likely to view, redistribute, and believe such content. However, preliminary evidence has suggested that race may also play a substantial r

Given the role of social media in the modern election, scholars should not only study how platforms function for political actors; we should also study how platforms function as political actors. This essay therefore introduces the concept of scandalous design, which refers to programmatic changes in how social media operate in response to scandal. On the one hand, scandals can encourage changes i

”Och så måste du ha ett avsnitt om etik också …” Forskningsetiken blir alltför ofta en pliktskyldig och standardiserad deklaration om att man följer regler. Studenten som skriver uppsats intygar om sin moraliska förträfflighet, och forskaren som söker anslag eller prövar sin forskning i en etisk nämnd gör likadant. Etiken i forskningspraktiken, det vill säga alla de etiska dilemman som uppkommer n

The cardiovascular branch of autonomic nervous system (ANS) is responsible for the regulation of heart rate, blood pressure, and maintaining homeostasis during physiological stress such as exercise and standing upright. ANS constantly controls the rate and force of heart contractions and the vascular tone with the aim to maintain the sufficient tissue perfusion with oxygenated blood and secure ven

English summary”Class Relations and Historical Economic Inequality: Stockholm in the Seventeenth and Eighteenth Centuries”.Erik BengtssonArbetarhistoria, 2020This article describes and discusses economic inequality in seventeenth and eighteenth century Stockholm. I describe the distribution of wealth, using probate inventories from 1650, 1700 and 1715, and wealth tax data from 1715. The distributi