Introduction: Several blood-based biomarkers are associated with neuronal injury, but their utility in interventional clinical trials is unclear. This study retrospectively evaluated the utility of plasma neurofilament light (NfL) and total tau (t-tau) in an 18-month trial in mild Alzheimer's disease (AD). Methods: Correlation and conditional independence analyses and Gaussian graphical models wer

β-Galactose derivatives have recently been reported to selectively inhibit galectin-3, and a library of O3-arylated galactosides with varying substitution patterns was designed to study such inhibitions further. The O3-arylated galactosides were synthesized using diaryliodonium salts under mild and transition metal free conditions, providing the target products in moderate to good yields. An O3-tr

We present how agent-based models can be used to correct for biases in a sample. The approach is generally useful for behavioural experiments where participants interact over time. The model we developed copied mechanics of a behavioural experiment conducted earlier, and agents in the model faced the same strategic choices as human participants did. We used the data from the experiment to calibrat

This paper applies an analytical method for developing policy strategies to optimize municipal waste management systems (MWMSs) to the case of the Land of Fires (LoF). The LoF is an area of Italy’s Campania region that is characterized by a legacy of authoritarian environmental governance and the improper dumping and burning of waste. In this paper, we employ the fuzzy cognitive maps (FCM) method,

This article traces the flow of municipal solid waste from southern Italy through a waste‐to‐energy facility and district heating system in Austria, examining the roles that waste's transformation from contaminant to commodity to fuel plays in interconnected, distributed, and contested urbanization processes. It contends that, while metabolic circulation hides socioecological costs in one place to

This introduction presents an overview of the key concepts discussed in the subsequent chapters of this book. The book describes the European Union's (EU) Member States have embarked on a unique project in seeking to create a collective foreign, security and defence policy. This collective foreign policy endeavour has been pursued whilst national foreign policies themselves have evolved. EU foreig

This conclusion presents some closing thoughts on the concepts covered in the preceding chapters of this book. The book empirically and comparatively, indicates the extent to which there is continuity or change in the foreign policy composition of key European Union (EU) Member States, as found across the 'strong-weak competence spectrum', and on this basis explore the extent to which the resultin

Worship space acoustics have been established as an important part of a nation’s cultural heritage and area of acoustic research, but more research is needed regarding the region of northern Europe. This paper describes the historical acoustics of an important abbey church in Sweden in the 1470s. A digital historical reconstruction is developed. Liturgical material specific to this location is rec

Rättsfallspodd från Juridiska fakulteten.Under andra världskriget är Vidkun Quisling norsk regeringschef i den tyska ockupationen av Norge. Efter kriget ställs Quisling inför rätta och åtalas för landsförräderi. Rättegången mot Quisling är en berättelse om nedmonteringen av den norska rättsstaten under ockupationen, men det är också en historia om hur norrmännen gjorde motstånd och försvarade rätt

On the 11th October 2016 the opposition Labour Party presented the ruling Conservative UK government with a list of 170 questions – one for each day before Theresa May’s self-imposed deadline to start the process of leaving the EU. A more realistic list of questions in the UK’s ‘Brexit’ debate right now would consist of 17 000 questions – the four decade-old UK-EU relationship raises so many quest

As the introductory chapter sets out, this volume critically interrogates the EU as a global actor and its normative power in global politics as part of the 2013 European Research Day of the Centre for European Research at Gothenburg University. This chapter will conclude this interrogation by providing a Copenhagen reflection on the EU as a global actor within the context of the Normative Power A

Recension av; I rikets tjänst. Krig, stat och samhälle i Sverige 1450-1550

De tyska ockupationsmyndigheternas totalförintelse av kustbyn Telavåg. Fiskeby förintades i tysk hämndaktion

The repeated occurrence of severe wildfires has highlighted the need for development of effective vegetation moisture monitoring tools. The normalized difference infrared index (NDII) derived from SPOT Vegetation satellite data and the Keetch-Byram drought index derived from temperature and rainfall data are both related to vegetation moisture dynamics. Autocorrelation of time series is a major is

Man brukar höra att evolution handlar om att de starkaste, de bäst lämpade, överlever. Detta för tankarna till en värld full med översittare, som hänsynslöst driver fram och lämnar de svaga bakom sig. Men det behöver inte vara så. Denna avhandling visar oss att gemenskap är styrka, och att evolutionen skapar liv där de svaga ibland sitter på de starkas axlar.Strutsar är märkliga varelser. De ser uPeople are used to hearing that evolution is about the survival of the fittest. Theyimagine a world full of bullies that ruthlessly fight their way to the top in the struggle for life, leaving the weak behind. But this doesn’t need be the case. This thesis reveals a different side of evolution, where survival means working together, and where the weak can ride on the shoulders of the fit.Ostriches