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Background: Cardiac resynchronization therapy (CRT) is an established therapy for appropriately selected patients with heart failure. Response to CRT has been heterogeneously defined using both clinical and echocardiographic measures, with poor correlation between the two. Methods: The study cohort was comprised of 202 CRT-treated patients and CRT response was defined at 6 months post-implant. Ech

Background and purpose — With a rapidly increasing population in need of total knee arthroplasty (TKA), there is renewed interest in cost-saving all-polyethylene designs. Differences between metal-backed and all-polyethylene designs in initial component migration assessed by radiostereometric analysis (RSA), a proven predictor for late aseptic loosening, have been scantily reported. The purpose of

Objectives: Feasibility testing of a psychoeducational method -The Affect School and Script Analyses (ASSA)–in a Swedish primary care setting. Exploring associations between psychological, and medically unexplained physical symptoms (MUPS). Design: Pilot study. Setting: Three Swedish primary care centers serving 20,000 people. Intervention: 8 weekly 2-hour sessions with a 5–7 participant group led

A search for high-mass resonances decaying to τν using proton-proton collisions at s=13 TeV produced by the Large Hadron Collider is presented. Only τ-lepton decays with hadrons in the final state are considered. The data were recorded with the ATLAS detector and correspond to an integrated luminosity of 36.1 fb-1. No statistically significant excess above the standard model expectation is observe

Background/Aims: Hemodialysis implies significant alterations in the profile of serum components. microRNAs (miRNAs) are present in the human serum and are considered to target distant tissues where they can regulate gene expression, thus affecting homeostasis. Whether hemodialysis alters the profile of miRNAs in the serum is not known. Methods: miRNA profiling in serum samples collected before an

In recent years, neuroscientific knowledge has been applied far beyond its context of emergence to explain human behaviour in general and to address a host of specific societal problems. In this article, we discuss the emerging research field of ‘neuropolitics’ that seeks to bring neuroscientific methods and findings to political science. Neuropolitics is investigated as a particular way of approa

An automatic component detection method for overlapping transient pulses in multi-component signals is presented and evaluated. The recently proposed scaled reassignment technique is shown to have the best achievable resolution for closely located Gaussian shaped transient pulses, even in heavy disruptive noise. As a result, the method automatically detects and counts the number of transients, giv

Endotoxemia-induced inflammation has been associated with insulin resistance and atherosclerosis, ultimately increasing the risk of coronary heart disease. Increased intestinal permeability is an important event leading to endotoxemia. This study aims to elucidate the possible association between endotoxin (lipopolysaccharide) and zonulin (a biomarker of intestinal permeability) levels and the ris

We use data from the Radial Velocity Experiment (RAVE) and the Tycho-Gaia astrometric solution (TGAS) catalogue to compute the velocity fields yielded by the radial (VR), azimuthal (Vϕ),and vertical (Vz) components of associated Galactocentric velocity. We search in particular for variation in all three velocity components with distance above and below the disc midplane, as well as how each compon

The education–fertility relationship is a central element of the models explaining the transition to sustained economic growth. But many determinants of this relationship have not yet received more systematic attention. In this paper, we apply a three-stages least-squares estimator on French county-level data, including newly collected data, to better understand the causal effects running from edu

Among the founders of French psychology, Pierre Janet (1859 –1947) is recognized forboth his scientific and institutional roles. The psychology born at the turn of the 20thcentury was initially partly receptive to, but then engaged in, a battle with the “psychical marvelous,” and Janet was no exception. He was involved in the split between psychology and parapsychology (or “metapsychics” in France

Förmågan att uppfatta ljus och vilken riktning det kommer från är utomordentligt användbart för djur. Därför är det inte förvånande att denna förmåga återfinns hos i stort sett varje större djurgrupp, även bland de som anses enkla, såsom koraller och spolmaskar. Endast några få djurgrupper har dock, under evolutionens gång, utvecklat verkligt bra ögon som snabbt kan identifiera objekt av djurens eLight-detection provides incomparabaly rapid information at a range of time scales and, consequently, directional photoreception is found in almost every major metazoan clade. Conversely, a much smaller cohort have evolved sophisticated high resolution vision, which facillitates complex tasks via the detection of fast or small objects,. such as courtship and high-speed pursuit of prey. A few such

BACKGROUND AND AIM Non-stop stair ascending at maximum speed is required to reach a safe refuge level from deep underground structures, such as subways and in high-rise buildings in an emergency evacuation situation. Endurance of stair climbing and identifying the time of the onset of leg’s local muscle fatigue (LMF) are interests in evacuation research. The objective of this laboratory study was

While the simple-system flute was primarily developed as a product of 19th century Western art music, it has since become established in other genres and traditions. The aim of the present study is to explore approaches towards the simple-system flute as it is used across genres and traditions today. These approaches are understood from the performers point of view, and focus on the relationship b

Social interaktion sker ofta i grupper. För barn är skolklassen en grupp de dagligen interagerar i. Skolklassen och den sociala interaktion som sker i skolan har stor betydelse för barns välmående och framtida sociala interaktioner. Lärarna i skolan har därför i uppdrag att arbeta med barns sociala samspel och mot kränkande behandling. Avhandlingens övergripande syfte att öka förståelsen för barnsSocial interaction often takes place in groups. The school class is an important group in which children interact. Children spend a large percentage of their day with their classmates in school and classmates are not only co-workers, but also individuals interacting socially as friends. Several studies show that social interaction and friendship in school effect children’s wellbeing, academic perf

Activating signaling mutations are common in acute leukemia with KMT2A (previously MLL) rearrangements (KMT2A-R). These mutations are often subclonal and their biological impact remains unclear. Using a retroviral acute myeloid mouse leukemia model, we demonstrate that FLT3 ITD, FLT3 N676K, and NRAS G12D accelerate KMT2A-MLLT3 leukemia onset. Further, also subclonal FLT3 N676K mutations accelerate

Time-dependent ensemble averages, i.e., trajectory-based averages of some observable, are of importance in many fields of science. A crucial objective when interpreting such data is to fit these averages (for instance, squared displacements) with a function and extract parameters (such as diffusion constants). A commonly overlooked challenge in such function fitting procedures is that fluctuations

Conscription forces young men to serve in the military, irrespective of their opportunity costs. Using random assignment in the Danish draft lottery, we find a negative average effect of peacetime military service on earnings, an effect varying by ability, with high-ability men facing a $23,000 lifetime earnings penalty but with low-ability men facing none. This gradient is robust to different mea

Many pathogenic bacteria utilise sialic acids as an energy source or use them as an external coating to evade immune detection. As such, bacteria that colonise sialylated environments deploy specific transporters to mediate import of scavenged sialic acids. Here, we report a substrate-bound 1.95 Å resolution structure and subsequent characterisation of SiaT, a sialic acid transporter from Proteus