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Structural effects of naturally occurring human blood group B galactosyltransferase mutations adjacent to the DXD motif
Human blood group A and B antigens are produced by two closely related glycosyltransferase enzymes. An N-acetylgalactosaminyltransferase (GTA) utilizes UDP-GalNAc to extend H antigen acceptors (Fuc alpha(1-2)Gal beta-OR) producing A antigens, whereas a galactosyltransferase (GTB) utilizes UDP-Gal as a donor to extend H structures producing B antigens. GTA and GTB have a characteristic (DVD213)-D-2
IL-1{beta} Induced Transcriptional Up-regulation of Bradykinin B1 and B2 Receptors in Murine Airways.
Hyperresponsiveness to bronchoconstrictor stimuli is a major pathophysiologic feature of asthma, but the molecular mechanisms behind this are not fully understood. The release of TNF-alpha and IL-1 beta during the inflammatory process is believed to play an important role in airway hyperresponsiveness. We have previously demonstrated, using a murine in vitro model of chronic airway inflammation, t
A numerical comparison of 2D resistivity imaging with 10 electrode arrays
Numerical simulations are used to compare the resolution and efficiency of 2D resistivity imaging surveys for 10 electrode arrays. The arrays analysed include pole-pole (PP), pole-dipole (PD), half-Wenner (HW), Wenner-alpha (WN), Schlumberger (SC), 'dipole-dipole (DD), Wenner-beta (WB), gamma-array (GM), multiple or moving gradient array (GD) and mid point-potential-referred measurement (MPR) arra
Anti-factor V auto-antibody in the plasma and platelets of a patient with repeated gastrointestinal bleeding
Development of autoantibody against coagulation factor V (FV) is a rare clinical condition with hemorrhagic complications of varying severity. The aim of this study was to establish the pathomechanism of an acquired FV deficiency and characterize the FV inhibitor responsible for the clinical symptoms. A 78-year-old female was admitted to hospital with severe gastrointestinal bleeding. General clot
High prevalence of small duct primary sclerosing cholangitis among patients with overlapping autoimmune hepatitis and primary sclerosing cholangitis
Background: Overlap syndrome is a term used for overlapping features of autoimmune hepatitis and primary sclerosing cholangitis or primary biliary cirrhosis and for autoimmune cholangitis. We describe a high prevalence of small duct primary sclerosing cholangitis among patients with overlapping autoimmune hepatitis and primary sclerosing cholangitis. Methods: We sought to retrieve all patients wit
Oscillation mechanics of the human lung periphery in asthma
To more precisely measure the mechanical properties of the lung periphery in asthma, we have developed a forced oscillation technique that applies a broad-band flow signal through a wedged bronchoscope. We interpreted the data from four healthy and eight mildly asthmatic subjects in terms of an anatomically accurate computer model of the wedged segment. There was substantial overlap in impedance b
Carbon partitioning between oil and carbohydrates in developing oat (Avena sativa L.) seeds
Cereals accumulate starch in the endosperm as their major energy reserve in the grain. In most cereals the embryo, scutellum, and aleurone layer are high in oil, but these tissues constitute a very small part of the total seed weight. However, in oat (Avena sativa L.) most of the oil in kernels is deposited in the same endosperm cells that accumulate starch. Thus oat endosperm is a desirable model
Characterization of graphite electrodes modified with laccases from Trametes hirsuta and Cerrena unicolor and their use for flow injection amperometric determination of some phenolic compounds
Fungal laccases from Trametes hirsuta and Cerrena unicolor were immobilized on spectroscopic graphite electrodes using physical absorption. The laccase-modified graphite electrodes were mounted as the working electrodes into a wall jet flow through an electrochemical cell and then used for flow injection amperometric determination of different phenolic compounds of relevance both for environmental
Isolation and characterization of polymorphic microsatellite loci for the Skyros wall lizard Podarcis gaigeae (Squamata: Lacertidae)
Fifteen polymorphic markers were developed from a microsatellite-enriched library for the lizard Podarcis gaigeae. The loci were checked for variability in 68 individuals from a population on the island of Skyros, Greece. The number of alleles ranged from 3 to 23 per locus and expected heterozygosity from 0.29 and 0.94. Most markers were also polymorphic in three closely related Podarcis species,
Visibility of the environmental noise modulating population dynamics
Characterizing population fluctuations and their causes is a major theme in population ecology. The debate is on the relative merits of density-dependent and density-independent effects. One paradigm (revived by the research on global warming and its relation to long-term population data) states that fluctuations in population densities can often be accounted for by external noise. Several empiric
Structure and magnetism of MnAs nanocrystals embedded in GaAs as a function of post-growth annealing temperature
Self-organized Ga(Mn)As nanoclusters, embedded in GaAs, were formed during post-growth thermal annealing of Ga1-xMnxAs layers. Structural and magnetic properties of such composites were systematically studied as a function of the annealing temperature. Small (similar to 3 nm) Mn-rich zinc-blende Mn(Ga)As clusters, coherent with the GaAs matrix, were formed at the annealing temperature of 500 degre
Electrophysiology of inducible atrial flutter in patients with atrioventricular nodal reentrant tachycardia.
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Explanations to the agrarian question in Malawi: A critical discussion
Robust Controller Design via Linear Programming
Intra-stage sequencing in second language acquisition : Empirical evidence from Arabic and Swedish data
Den utsträckta TV:n - Ett exempel ur praktiken
Popular Abstract in Swedish Syftet med den här licentiatuppsatsen är dels att beskriva äldre människors intresse av och möjligheter till att använda TV:n till annat än traditionellt TV-tittande, dels att beskriva olineariteterna i den designprocess i vilken detta arbete ägde rum. Konceptet ”Den utsträckta TV:n” utvecklades och provades (av äldre människor, deras anhöriga och personal) i en ny våThe aim of this licentiate thesis is twofold: 1) to describe old people’s interest in and prospects of using the television for something other than traditional TV viewing, and 2) to describe the nonlinearities in the design process in which this research was performed. A concept called The Extended TV was developed and tested (by old people, their relatives and care workers) in a new nursing home
From rough to final designs by incremental set-inclusion of properties
Design of buildings is a complex task in which ideas are sketched and communicated, by representations that are incrementally elaborated from the early rough sketches to the final design. We claim, that today’s model–based design tools are restricted from fully supporting this process as they are founded on the principle that objects are instances of static types. Such systems do not offer work wi
