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Background: The size of pancreatic ductal adenocarcinoma (PDAC) at diagnosis is an indicator of outcome. Previous studies have focused mostly on patients with resectable disease. The aim of this study was to investigate the relationship between tumour size and risk of metastasis and death in a large PDAC cohort, including all stages. Methods: Patients diagnosed with PDAC between 1988 and 2013 were
Clinical trials examining insulin-like growth factor-I receptor (IGF1R)-targeting strategies have emphasized that better predictive biomarkers are required to improve patient selection. Immunohistochemical tumor-specific protein expression of IGF1R, insulin receptor (InsR), and phosphorylated IGF1R/InsR (pIGF1R/InsR) individually and combined in relation to breast cancer prognosis was evaluated in
Background It has been suggested that target temperature management (TTM) increases the probability of infectious complications after cardiac arrest. We aimed to compare the incidence of pneumonia, severe sepsis and septic shock after out-of-hospital cardiac arrest (OHCA) in patients with two target temperatures and to describe changes in biomarkers and possible mortality associated with these inf
Introduction: The prevalence of metabolic syndrome (MetS) is increasing in Iran. We assessed the relationship between socioeconomic status (SES) and Mets components in the Iranian population. Materi- als and Methods: The sample for this study comprised a random cross-section of men and women from two province districts who participated in the Isfahan Healthy Heart Program (IHHP) in 2007. Each part
B-cell malignancies (BCM) originate from the same cell of origin, but at different maturation stages and have distinct clinical phenotypes. Although genetic risk variants for individual BCMs have been identified, an agnostic, genome-wide search for shared genetic susceptibility has not been performed. We explored genome-wide association studies of chronic lymphocytic leukaemia (CLL, N = 1,842), Ho
Wounds are classified as acute or chronic. Acute wounds are divided into traumatic and surgical. In intact skin, the normal bacterial colonization is balanced. A wound jeopardizes this balance and infection may occur. In acute wounds, the presence of particular bacterial species such as Staphylococcus aureus seems to be a risk factor for the occurrence of an infection. To reduce the risk of surgic
Purpose: To present a patient with ruptured abdominal aortic aneurysm (AAA) and aortocaval fistula who was successfully treated with endovascular aneurysm repair in spite of developing a massive endoleak. Case Report: A 70-year-old man with ruptured AAA and aortocaval fistula was treated with endovascular aneurysm repair (EVAR). During 8 years of followup, he had massive perfusion of the aneurysm
Background: Complement is an important mediator in arterial blood pressure-induced vein graft failure. Previously, we noted activation of cell protective mechanisms in human saphenous veins too. Here we have analyzed whether C4b-binding protein (C4bp), an endogenous complement inhibitor, is present in the vein wall. Methods: Human saphenous vein segments obtained from patients undergoing coronary
When the characteristics of a system, its environment and the specifications are given in terms of external models it is very natural to use algebraic system theory to design control systems. Different problems of this type are discussed in the paper. It is shown that many design problems can be solved in a uniform, simple and direct way using algebraic system theory. Relations to other methods of
Objective: Present a systematic analysis of the outcome research concerning video feedback (VF) programs. Method: Twentyninestudies published between 1990 and 2014 were examined. They focused on children 0–12 years old and had at least onecontrol group. Results: VF programs were similar in design, with interventions focusing on parental and child behavior, parentalsensitivity and attachment. In 41Objective: Present a systematic analysis of the outcome research concerning video feedback (VF) programs. Method: Twenty- nine studies published between 1990 and 2014 were examined. They focused on children 0–12 years old and had at least one control group. Results: VF programs were similar in design, with interventions focusing on parental and child behavior, parental sensitivity and attachment.
Adult hematopoietic stem cells (HSCs) reside in bone marrow and are maintained in a dormant state within a special microenvironment, their so-called "niche". Detaching from the niche induces cell cycle progression, resulting in a reduction of the reconstitution capacity of HSCs. In contrast, fetal liver HSCs actively divide without losing their stem cell potentials. Thus, it has been unclear what
Despite the maturity reached by targeted proteomic strategies, reliable and standardized protocols are urgently needed to enhance reproducibility among different laboratories and analytical platforms, facilitating a more widespread use in biomedical research. To achieve this goal, the use of dimensionless relative retention times (iRT), defined on the basis of peptide standard retention times (RT)
Asymptomatic bacteriuria (ABU) is a bacterial carrier state in the urinary tract that resembles commensalism at other mucosal sites. ABU strains often lack the virulence factors that characterize uropathogenic Escherichia coli (E. coli) strains and therefore elicit weak innate immune responses in the urinary tract. In addition, ABU strains are active modifiers of the host environment, which they i
We have established a novel strategy to reduce the risk for recurrent urinary tract infection (UTI), where rapidly increasing antibiotic resistance poses a major threat. Epidemiologic studies have demonstrated that asymptomatic bacteriuria (ABU) protects the host against symptomatic infections with more virulent strains. To mimic this protective effect, we deliberately establish ABU in UTI-prone p
We consider consecutive random subdivision of polygons described as follows. Given an initial convex polygon with d≥3 edges, we choose a point at random on each edge, such that the proportions in which these points divide edges are i.i.d. copies of some random variable ξ. These new points form a new (smaller) polygon. By repeatedly implementing this procedure we obtain a sequence of random polygon
Start with a graph with a subset of vertices called {\it the border}. A particle released from the origin performs a random walk on the graph until it comes to the immediate neighbourhood of the border, at which point it joins this subset thus increasing the border by one point. Then a new particle is released from the origin and the process repeats until the origin becomes a part of the border it
