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Neuroblastomas (NBs) are tumours of the sympathetic nervous system accounting for 8-10% of paediatric cancers. NBs exhibit extensive intertumour genetic heterogeneity, but their extent of intratumour genetic diversity has remained unexplored. We aimed to assess intratumour genetic variation in NBs with a focus on whole chromosome changes and their underlying mechanism. Allelic ratios obtained by S

OBJECTIVE-Age at menopause is an important determinant of future health outcomes, but little is known about its relationship with type 2 diabetes. We examined the associations of menopausal age and reproductive life span (menopausal age minus menarcheal age) with diabetes risk. RESEARCH DESIGN AND METHODS-Data were obtained from the InterAct study, a prospective case-cohort study nested within the

A numerical model that combines a random wave transformation and a wave-induced current model was developed in order to predict the wave and current fields around a detached breakwater. The wave field was determined using the EBED model, as reported by Mase in 2001, with a modified energy dissipation term. The surface roller associated with wave breaking was modeled based on a modification of the

An electrochemical biosensor based on ZnO nanorods for potentiometric cholesterol determination is proposed. Hexagon-shaped ZnO nanorods were directly grown on a silver wire having a diameter of 250 mu m using low temperature aqueous chemical approach that produced ZnO nanorods with a diameter of 125250 nm and a length of similar to 1 mu m. Cholesterol oxidase (ChOx) was immobilized by a physical

Popular Abstract in Swedish Om blodkärlen i ögat läcker eller om blodflödet stoppas får inte näthinnan den mängd syre och näring som den behöver. Detta tillstånd kallas ischemi och kan leda till att näthinnans celler skadas. Näthinnan ligger längst bak i ögat och fungerar som filmen i en kamera. Stavar och tappar registrerar ljus och signalen går via nerver till syncentra i hjärnan. Blodkärl (artäIdentification of the intracellular signal transduction pathways activated in retinal ischaemia may be important in revealing novel pharmacological targets. The retinal blood vessels are key organs in circulatory failure, and in this work the retinal vasculature was therefore examined separately from the neuroretina. The porcine eye has a typical primate-like architecture and is similar to the hum

The ATLAS experiment at the LHC has measured the centrality dependence of charged particle pseudorapidity distributions over vertical bar eta vertical bar < 2 in lead-lead collisions at a nucleon-nucleon centre-of-mass energy of root s(NN) = 2.76 TeV. In order to include particles with transverse momentum as low as 30 MeV, the data were recorded with the central solenoid magnet off. Charged partic

We compare different preference restrictions that ensure the existence of a stable roommate matching. Some of these restrictions are generalized to allow for indifferences as well as incomplete preference lists, in the sense that an agent may prefer remaining single to matching with some agents. We also introduce a new type of cycles and in greater detail investigate the domain of preferences that

The thesis covers different topics related to model predictive control (MPC) and particularly distributed model predictive control (DMPC). One topic of the thesis is gradient-based optimization algorithms for solving the optimization problem arising in DMPC in a distributed manner. The underlying idea is to solve the optimization problem in distributed fashion using dual decomposition, which is a

PURPOSE. To determine the proportion of male patients presenting simplex retinal degenerative disease (RD: retinitis pigmentosa [RP] or cone/cone-rod dystrophy [COD/CORD]) with mutations in the X-linked retinal degeneration genes RPGR and RP2. METHODS. Simplex males were defined as patients with no known affected family members. Patients were excluded if they had a family history of parental consa

The PHENIX experiment at RHIC has embarked on a broad range of upgrades to enhance its physics reach. One of the upgrades consists of a set of silicon vertex trackers that combine to cover the pseudorapidity range − 2.4 to 2.4. A description of the vertex detectors and some of their physics goals and capabilities will be given, as well as technology choices and results from prototype components.

OBJECTIVES: To investigate the association between marital status and lack of internal health locus of control (HLC), taking economic stress and trust into account. STUDY DESIGN: Cross-sectional study. METHODS: The public health survey Skåne 2008 is a postal questionnaire study (55% participation rate). A random sample was invited to participate, and 28,198 individuals aged 18-80 years agre

Nature provides science and society with a virtually unlimited supply of structurally diverse and biologically active molecules; the natural products. While some are directly useful in commercial applications, others are valuable for studying and understanding biological phenomena at the molecular level. An example is the signaling of nerve cells, which has been explored in considerable detail usi

The Constructal Theory is applied to obtain better thermal performance from a type of microchannel heat sink. Based on a smooth, straight, rectangular microchannel heat sink (Case 1), three different configurations of constructal multiple bifurcation are designed for the entrance region of each microchannel. These types are one bifurcation (Case 2), two bifurcations with the second placed in the f

Mortality rates for Wegener's granulomatosis (WG) and microscopic polyangiitis (MPA) have decreased after the introduction of cyclophosphamide. Standardized mortality ratio (SMR) expresses the overall mortality of patients compared with the general population. The aims of this study were to compare survival in an old and a recent cohort of patients with WG and MPA using SMR and to determine predic

The difficulty of obtaining accurate information about the canopy structure is a current limitation towards higher accuracy in numerical predictions of the wind field in forested terrain. The canopy structure in computational fluid dynamics is specified through the frontal area density and this information is required for each grid point in the three-dimensional computational domain. By using raw

We report a patient with a transient ischemic attack presumably caused by an entrapment of the internal carotid artery by the hyoid bone and without a significant carotid artery stenosis. The patient was operated on, with a release of the right internal and external carotid artery and resection of the right greater cornu of the hyoid bone. One year after treatment, the patient has not experienced