Sökresultat

Human dihydroorotate dehydrogenase (DHODH) is the rate-limiting enzyme in pyrimidine de novo synthesis and represents a promising target for cancer therapy. However, current inhibitors of DHODH have limited clinical effectiveness and adverse effects. Herein, we report NK-A 17E-233I, a novel small-molecule inhibitor of the human DHODH enzyme, identified through a prospective virtual screening metho

PFAAs emission to the environment represents a potential risk to human health. Although, long-term global scale fate and transport models have been used to investigate potential trends in environmental levels, temporal trends and transports mechanisms of PFAAs are not fully understood. Due to high solubility in water, the behaviour of PFAAs in soil is important for environmental fate estimation an

The influence of three organic compounds and bakers' dry yeast on growth of external mycelium and phosphorus uptake of the arbuscular mycorrhizal fungus Glomus intraradices Schenck and Smith (BEG 87) was examined. Two experiments were carried out in compartmentalized growth systems with root-free sand or soil compartments. The sand and soil in the root-free compartments were left untreated or unif

Soil microbes drive ecosystem function and play a critical role in how ecosystems respond to global change. Research surrounding soil microbial communities has rapidly increased in recent decades, and substantial data relating to phospholipid fatty acids (PLFAs) and potential enzyme activity have been collected and analysed. However, studies have mostly been restricted to local and regional scales

Studies in temperate systems provide evidence that the abundance of arbuscular mycorrhizal fungal (AMF) depends on soil nutrient availability, which is mainly explained in the context of resource stoichiometry and differential plant biomass allocation. We applied this concept to an understudied ecosystem - tropical montane forest - analyzing root and AMF abundance along an elevational gradient wit

Deforestation and the use of fire to clear land have drastic effects on ecosystem functioning and compromise essential ecosystem services, especially in low-income tropical countries such as Madagascar. We evaluated the effects of local slash-and-burn practices on soil nutrients and arbuscular mycorrhizal (AM) fungi abundance in a southwestern Madagascar forest. Nine sampling plot pairs were estab

Objective: Enhancing the reliability of myoelectric controllers that decode motor intent is a pressing challenge in the field of bionic prosthetics. State-of-the-art research has mostly focused on Supervised Learning (SL) techniques to tackle this problem. However, obtaining high-quality labeled data that accurately represents muscle activity during daily usage remains difficult. We investigate th

This paper presents a decentralized strategy for a team of N robotic manipulators cooperatively grasping and manipulating an object. A two-step strategy has been designed. In the first step, each robot runs N − 1 consensus-based estimators to estimates the wrenches applied to the object by its teammates even when direct all-to-all communication is unavailable. In the second step, each manipulator

This paper addresses the time-optimal path-tracking problem for redundant manipulators. By integrating path-velocity control into existing task-space robot controllers, the task-space motion can be dynamically scaled to satisfy the torque constraint under both kinematic and dynamic uncertainties. Numerical simulations and experiments demonstrate that trajectory feasibility and path-tracking accura

Denna avhandling undersöker oberoende kulturproduktion som idé(al) och fenomen, särskilt den centrala roll som samarbeten och ömsesidiga beroenden har för oberoende kulturaktörer. Samtida oberoende kulturproduktion både tillåter och kräver organisering i ett spänningsfält av olika förväntningar och begränsade rumsliga, finansiella och mänskliga resurser. I en tid av allt starkare politisk motvind,This thesis engages with the phenomenon of independent cultural production, which empirically shows itself as an idea(l) of self-determined cultural production and collaboration made possible through numerous different relationships. Independence, as a relational concept, achieved through in(ter)dependencies is what this thesis sets out to explore. Definitions of independence in cultural productio

Phosphorus deficiency exacerbates the challenges of phytoremediation in mining areas, particularly for herbaceous species. Although Melilotus officinalis L. Pall. (Melilotus) serves as a pioneer species in mine reclamation, its response mechanisms to phosphorus deficiency stress (PDS)—particularly regarding root exudates composition, plant growth, soil properties, and key microbial functional grou

Trimethylolpropane (TMP) is an important industrial chemical used to produce various value-added chemicals and polymers. In this study, both biobased butyraldehyde and formaldehyde were produced by the incomplete oxidation of bio-1-butanol and biomethanol, respectively, and were then used to produce a biobased TMP. High selective incomplete oxidation of primary alcohol to aldehyde is a challenging

This study explores the use of manganese ore, iron-carbon particles (Fe-C), and gravel as anode fillers in electroactive constructed wetlands (ECWs) to treat wastewater containing pharmaceuticals and personal care products (PPCPs) including ciprofloxacin (CIP), ofloxacin (OFL), and naproxen (NPX), while also assessing bioelectricity production. Although the presence of PPCPs reduced pollutant remo

En historia om fyra framstående finsk-amerikanska musiker i början av 1900-talet: Einar Swan, Sylvester Ahola, Wäinö Kauppi och Emil Hurja.A history of four prominent Finnish-American musicians in the early 20th century: Einar Swan, Sylvester Ahola, Wäinö Kauppi and Emil Hurja.

This chapter has its origins in a Swedish version but has been updated through studies conducted as part of a Nordic research project on the 0governance of AI and automated decision-making in the public sector, and within the framework of a research cluster on the AI welfare state. The analysis aims to deepen our understanding of how European AI regulation is grappling with regulating a moving tar

In order to elucidate the multidimensional response mechanism for migration of antibiotics and spread of resistome in riverbed driven by river water level fluctuations, dynamic reactors were set up to simulate the variation of sulfamethazine vertical migration, biotransformation and resistance genes expression according to fluctuation direction and magnitude. The upward fluctuation of water level

Flexural bond strength is a key parameter influencing the structural performance of masonry, yet its accurate prediction remains challenging due to the complex interplay of multiple material and testing variables. This study presents a machine learning (ML) framework for predicting flexural bond strength using a harmonized database comprising 1041 test specimens. Additionally, a review of 67 publi

This study investigates the impact of brick types and workmanship on water penetration in brick masonry veneer walls. Masonry specimens, built by two masons using solid and perforated bricks with two different laying methods, were subjected to an average water spray rate of 28 l/m²·h. Results indicate that, on average, the water penetration rate was approximately twice as high in solid bricks as i

This paper examines prominence from a pragmatic, phonological and acoustic-articulatory perspective. Based on results of a corpus-based analysis of Topic prosodic units in four languages (Italian, Brazilian and European Portuguese, and American English), three types of topic prosodic forms (TPFs) are described. Also are reviewed studies reporting phonological organization of English prominence pat

Our relationships with others structure many aspects of our lives, especially during important moments such as choosing an education, entering the workforce, forming partnerships or starting a family. While the influence of family and parenting has been widely studied, less is known about the role of non-family connections, such as neighbours. One reason is that the data needed to study these rela