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BACKGROUND: The incidence of cutaneous malignant melanoma (CMM) continues to increase in most countries worldwide and the majority are diagnosed with thin tumours (≤ 1 mm).OBJECTIVES: The aim of the present study was to investigate the melanoma-specific survival (MSS) as well as conditional MSS (CMSS) in patients with thin CMM in Sweden.PATIENTS AND METHODS: Clinical and histological parameters we
Background: Melanomas that arise on mucosal surfaces and the glans penis are rare. Methods: A retrospective study of the Sydney Melanoma Unit experience with 69 patients treated since 1956 for these types of melanomas was undertaken to determine primary lesion site, sex, age at diagnosis, symptoms, clinical stage at first presentation, histopathology, treatment and outcome. Results: Primary lesion
BACKGROUND: Gleason grading is the standard diagnostic method for prostate cancer and is essential for determining prognosis and treatment. The dearth of expert pathologists, the inter- and intraobserver variability, as well as the labour intensity of Gleason grading all necessitate the development of a user-friendly tool for robust standardisation.OBJECTIVE: To develop an artificial intelligence
The Tibetan Plateau is the highest and largest plateau in the world, hosting unique alpine grassland and having a much higher snow cover than any other region at the same latitude, thus representing a “climate change hot-spot”. Land surface phenology characterizes the timing of vegetation seasonality at the per-pixel level using remote sensing systems. The impact of seasonal snow cover variations
Across the world, economic interests and state-making interventions have converged to dispossess small-scale farmers, rural and urban dwellers – often through violent means. Situated in the sugarcane plantation landscape in the Cauca Valley in western Colombia, this dissertation explores how life is lived after dispossession. The research is based on ethnographic fieldwork in the Afro-descendant v
Objectives: To find possible predictive factors to predict the failure of conservative treatment of non-tubal ectopic pregnancy. For that purpose, we assessed the rate of failure, complications and need for additional interventions of the different primary treatment regimens in non-tubal ectopic pregnancies that occurred in our center. Study design: Retrospective single-center study conducted at H
This study examines the function of exaggeration for thinking beyond the current concepts of God and the human. An example of thinking beyond in philosophy is the exaggeration “beyond being” in Plato’s Republic. In the philosophy of religion, generally, we deal with the questions of God. The present study discerns as an instance of thinking beyond the thinking about God and the human. The study ai
'Arena' is the story of the resource struggle of a small Afro-descendant village in western Colombia. Surrounded by sugarcane plantations to all sides, the villagers base their livelihoods on manual sand extraction in the nearby river, supplying materials to local and regional construction markets. The river constitutes a fundamental pillar in the village; it is from this that they draw meaning an
We describe the details of a silicon–tungsten prototype electromagnetic calorimeter module and associated readout electronics. Detector performance for this prototype has been measured in test beam experiments at the CERN PS and SPS accelerator facilities in 2015/16. The results are compared to those in Monte Carlo Geant4 simulations. This is the first real-world demonstration of the performance o
At a large tunnel project in Southern Sweden a number of geoelectrical and IP imaging were carried out. The tunnel is drilled through a horst with a complex geology which includes fractures, high water content and weathered zones. The measurements where carried out to compile a geologic model to use in the further planning of the project. The resistivity and IP complements each other very well sin
There has been a strong quest for mapping and assessing ecosystem services (ES) to support governance. Yet, the institutional landscape that governs ES provision across multiple contexts has received less attention. We fill this research gap by developing and operationalising a framework for the analysis of policy documents that address European forest ES provision. By coding and analysing referen
In this paper, we determined the optimal flow rate trajectory during the loading phase of a mAb capture column. For this purpose, a multi-objective function was used, consisting of productivity and resin utilization. Several general types of trajectories were considered, and the optimal Pareto points were obtained for all of them. In particular, the presented trajectories include a constant-flow l
Supercritical fluids offer considerable advantages for the isolation of natural products. Supercritical fluids can be used as antisolvents to precipitate selectively target compounds from a mixture and to remove impurities by the Supercritical Antisolvent technique (SAS). The present decade has experienced a considerable increase in the number of publications that apply this technique to natural e
Electrical resistivity tomography (ERT) can be used to monitor the interior of hydropower embankments dams, and thereby detect zones with anomalous material properties and flow induced variation in the resistivity caused by changes in total dissolved solids (TDS) and temperature. Furthermore, monitoring of embankment dams in connection with a substantial change in the reservoir water level can det
Milk powders are commonly used for a variety of food products in which among others the milk proteins add to the properties of the products. Processing of milk can, depending on the processing parameters, change the size and structure of the proteins. These changes can be difficult to measure due to the polydispersity of milk components, which makes it a challenge to obtain direct information abou
Background: Bacterial vaginosis (BV) is the most common cause of vaginal discharge. It is caused by an imbalance in the normal vaginal microbiota. Symptoms include an offensive odour. Standard oral or vaginal antimicrobial treatments have high immediate cure rates but almost as high recurrence rates. pHyph, a vaginal pessary, contains glucono-delta-lactone (GDL) and sodium gluconate (NaG) which re
Purpose: The small molecule inhibitors larotrectinib and entrectinib have recently been approved as cancer agnostic drugs in patients with tumours harbouring a rearrangement of the neurotrophic tropomyosin receptor kinase (NTRK). These oncogenic fusions are estimated to occur in 0.1–3 % of non-small cell lung cancers (NSCLC). Although molecular techniques are most reliable for fusion detection, im
